| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC8806 | NS-398 Featured | NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). |
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| DC10255 | Parecoxib | Parecoxib is a selective COX2 inhibitor. |
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| DCAPI1503 | PARECOXIB SODIUM | PARECOXIB SODIUM |
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| DC9280 | BMS-1 (PD1/PDL1 inhibitor 1) Featured | PD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor,IC50 values: 0.006-0.10 μM,a useful immunomodulator compound. |
|
| DC8381 | PD-1/PD-L1 inhibitor 2(BMS-202) Featured | PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM,a useful compound immunomodulator compound. |
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| DC11185 | PF-06426779 | PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM. |
|
| DC1107 | PF-543 Featured | PF-543 is a novel Sphingosine kinase 1 (SphK1, SK1) inhibitor with Ki of 3.6 nM. |
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| DC9071 | Piroxicam | Piroxicam (Feldene) is a non-selective COX inhibitor with an IC50 of 6 mM. |
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| DC11373 | Polmacoxib | Polmacoxib is an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrase subtypes I (CAI) and CAII. |
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| DC11161 | RB-005 | RB-005 (RB-005) is a potent, selective inhibitor of sphingosine kinase SphK1 (SK1) with IC50 of 3.6 uM, displays 15-fold selectivity over SphK2.. |
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| DC10729 | SB9200(Inarigivir soproxil) Featured | SB9200(Inarigivir soproxil) is a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants. |
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| DC7030 | SC-560 Featured | SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex™) and rofecoxib (Vioxx™). |
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| DC10379 | SDMA Featured | SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. |
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| DC11072 | SINCRO | SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes. |
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| DC26063 | STING Agonist C11 Featured | STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway. |
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| DC12505 | STING agonist-4 Featured | STING agonist 4 is an amidobenzimidazole (ABZI)-based compound that functions as a STING agonist with Kd of 1.6 nM (binding of endogenous full-length STING, THP-1 cell lysates); caused dose-dependent phosphorylation of IRF3 and STING that was inhibited by the TBK1 inhibitor BX795, induced dose-dependent secretion of IFN-β with EC50 of 3.1 uM in PBMCs (18-fold more potent than cGAMP); promotes production of IFN-γ-induced protein 10 (IP-10), IL-6 and TNFα by a mechanism that is dependent on STING-mediated activation of TBK1; unlike cGAMP and DMXAA, compound 2 efficiently activates STING function while maintaining an open STING confirmation. |
|
| DC11451 | STING agonist compound 1 Featured | diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
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| DC11179 | STING CDN agonist IFM Therapeutics | STING CDN agonist IFM Therapeutics is a synthetic cyclic dinucleotide (CDN) agonist of STING, stimulates potent immunity against cancer.. |
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| DC10960 | STING inhibitor C-176 Featured | STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING |
|
| DC10959 | STING inhibitor C-178 Featured | STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING). |
|
| DC10268 | (+/-)-Sulfinpyrazone | Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules. |
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| DCAPI1388 | Suplatast tosylate | Suplatast tosylate |
|
| DC7305 | TAK-242 (Resatorvid) Featured | TAK-242 (Resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. |
|
| DC11263 | COX-1 Inhibitor IV（TFAP） Featured | The COX-1 Inhibitor IV, TFAP controls the biological activity of COX-1. |
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| DC10963 | TLR7 and 8 modulator 31 | TLR7 and 8 modulator 31 is a potent, orally active, dual TLR7 and 8 agonist with LEC values of 0.15 and 0.16 uM, respectively. |
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| DC9405 | Valdecoxib | Valdecoxib (SC 65872) is a COX-2 selective inhibitor with an IC50 value of 5 nM. |
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| DC9274 | YM 90709 Featured | YM 90709 has been reported to be a selective inhibitor of interleukin-5 (IL-5). |
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| DC9408 | Zaltoprofen | Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis. |
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| DC9254 | MCC950 (CP-456773) sodium Featured | MCC950 (CP-456773) sodium is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs. |
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| DC22331 | STING agonist compound 3 Featured | STING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. |
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