SINCRO|

Cas No.:	1494619-28-1
Chemical Name:	N-{3-[(1,4'-bipiperidin)-1'-yl]propyl}-6-[4-(4-methylpiperazin-1-yl)phenyl]picolinamide
SMILES:	C(C(NCCCN1CCC(N2CCCCC2)CC1)=O)1=NC(C2=CC=C(N3CCN(C)CC3)C=C2)=CC=C1
Formula:	C₃₀H₄₄N₆O
M.Wt:	504.723
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes; SINCRO (STING-mediated interferon-inducing and cytotoxic reagent, original) shows a STING-independent cytotoxic activity against cancer cells, SINCRO does not evoke DNA double-strand break or caspase-3 cleavage, induces cell death in a manner different from conventional apoptosis-inducing pathways; significantly attenuates in vivo tumor growth by both type I IFN-dependent and independent mechanisms.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47180	IACS-8803 diammonium	IACS-8803 diammonium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 diammonium has a robust systemic antitumor efficacy.
DC47134	Cyclic-di-GMP diammonium	Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species.
DC46506	E7766 disodium	E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities.
DC46412	STING agonist-3 trihydrochloride	STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pEC50 of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
DC45896	E7766 diammonium salt	E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.
DC44158	IACS-8803 disodium	IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy.
DC40210	STING ligand-1	STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING.
DC40090	Cyclic-di-GMP sodium	Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species.
DC11179	STING CDN agonist IFM Therapeutics	STING CDN agonist IFM Therapeutics is a synthetic cyclic dinucleotide (CDN) agonist of STING, stimulates potent immunity against cancer..
DC11072	SINCRO	SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes.