| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC9998 | 1400W dihydrochloride Featured | 1400W dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). |
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| DC12367 | Cyclic guanosine monophosphate-adenosine monophosphate Featured | 2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA. |
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| DC11060 | 3-Bromo-7-Nitroindazole | 3-Bromo-7-Nitroindazole is a more potent inhibitor of nNOS than 7-nitroindazole in vitro, is also potent against iNOS, inhibits rat nNOS, bovine eNOS, and rat iNOS with IC50 of 0.17, 0.86, and 0.29 uM.. |
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| DC11801 | AX-000 | A hit compound that inhibits the proliferation of human peripheral blood T cells stimulated with anti-CD3 with IC50 of <10 nM, inhibits TCR-Nck interaction.. |
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| DC11497 | IRAK4-IN-28 | A novel potent, selective IRAK4 inhibitor with IC50 of 51 nM. |
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| DC11826 | ASP-6537 | A novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM. |
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| DC11641 | Cridanimod Featured | A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. |
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| DC11688 | Avacopan Featured | Avacopan is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM. |
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| DC5027 | ABC294640（Opaganib） Featured | ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. |
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| DC9900 | Acetaminophen Featured | Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. |
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| DC9406 | Ampiroxicam | Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. |
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| DC11802 | AX-024 free base Featured | AX-024 is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. |
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| DC10545 | AX-024 HCl Featured | AX-024 is the first-in-class inhibitor of T cell receptor (TCR); AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). |
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| DC11058 | BYK191023 | BYK191023 (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86 nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162 uM). |
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| DC11059 | BYK191023 dihydrochloride | BYK191023 dihydrochloride (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86 nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162 uM). |
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| DC10276 | C29 Featured | C29 is a potential TLR2 inhibitor. |
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| DC10330 | PD-1-IN-17 Featured | PD-1-IN-17 has CAS#CAS:1673560-66-1, which is a programmed cell death-1 (PD-1) inhibitor. PD-1-IN-17 was first reported in patent WO2015033301A1, (Compound 4), inhibits 92% splenocyte proliferation at 100 nM. PD-1-IN-17 may be related to CA-170 (AUPM170), which is a potent PD-1 inhibitor and curreently under clinical trials. |
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| DC10648 | CA4948-Analog Featured | CA4948-Analog is an analog of Emavusertib. It has similar property to CA-4948, which is a potent, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. It was reported in patent WO 2015104688. Emavusertib, also known as CA-4948 i |
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| DCAPI1491 | Celecoxib Featured | Celecoxib is a selective Cox-2 inhibitor (IC50 of 40 nM). Celecoxib shows low sensitivity against Cox-1 (IC50 of 15 μM). Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 (IC50of 32.86 μM) and CNE1-LM |
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| DC9169 | Chloroquine diphosphate | Chloroquine diphosphate is an antimalarial drug and autophagy/lysosome inhibitor; inhibits Toll-like receptor (TLR) signalling in plasmacytoid dendritic cells (pDCs). |
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| DC11642 | Cridanimod sodium Featured | Cridanimod sodium is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. |
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| DC10771 | CU-CPT-8m Featured | CU-CPT-8m is a nolve TLR8 inhibitor. |
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| DC10769 | CU-CPT-9b Featured | CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). |
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| DC10770 | CU-CPT-9a Featured | CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8). It inhibits activation of NF-κB induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-κB p65, IRAK-4, and TRAF3 protein levels in HEK-Blue cells. |
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| DC10620 | CY-09 Featured | CY-09 is an NLRP3 inhibitor. |
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| DC11082 | Danicopan (ACH-4471) Featured | Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM. |
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| DC8911 | Deracoxib | Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID). |
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| DC12321 | STING agonist-1 trihydrochloride Featured | diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist. |
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| DC9064 | Diclofenac sodium | Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. |
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| DC7404 | DMXAA Featured | DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively. Phase 3. |
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