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Inhibitors & Agonists

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Cat. No. Product Name Field of Application Chemical Structure
DCC4075 Pergolide Mesylate Agonist of dopamine receptor subtypes D1 and D2
DCC4076 Peridinin Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation
DCC4077 Perindopril Non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor
DCC4078 Pet-16 Novel allosteric inhibitor of E. coli Hsp70 (DnaK) and human Hsp70 proteins
DCC4079 Pex14-pex5 Inhibitor-5 First Inhibitor of PEX14-PEX5 Protein-Protein Interaction (PPI) with Trypanocidal Activity
DCC4080 Pf-03084014 Novel γ-secretase inhibitor
DCC4081 Pf-03671148 Dose dependent inhibitor of multiple fibrotic genes
DCC4082 Pf-04363467 Hydrochloride Selective dopamine D3/D2 receptor antagonist
DCC4083 Pf-04671536 Hydrochloride Novel potent and selective PDE8B/8A inhibitor
DCC4084 pf-04859989 Irriversible inhibitor of kynurenine amino transferase II (KAT II)
DCC4085 Pf-05109794 Novel selective hTRPV4 Antagonist (hTRPV4 IC50 49nM; rTRPV4 IC50 1,150nM)
DCC4086 Pf-05214030 Novel potent TRPV4 antagonist (hTRPV4 IC50 4nM; rTRPV4 IC50 27nM)
DCC4087 Pf-06371900 Novel potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor
DCC4088 Pf-06424439 Mesylate Featured Potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2)
DCC4089 Pf-06655075 Novel non-brain-penetrant long-acting peptide oxytocin (OT) receptor agonist with increased selectivity for the OT receptor and significantly increased pharmacokinetic stability
DCC4090 Pf-06745013 Novel potent and selective inhibitor of MAP4K4
DCC4091 Pf-06756394 Novel tyrosine residues probe, rationally targeting active site
DCC4092 Pf-06758955 Hydrochloride Novel potent and selective inhibitor of MAP4K4
DC30002 PF-06835919 Featured PF-06835919, also known as MDK1846, is a potent ketohexokinase (KHK) inhibitor. PF-06835919 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders.
DCC4094 Pf-06843195 Prodrug Novel prdrug of PF-06843195, a potent PI3Kα-selective inhibitor
DCC4095 Pf-06939999 Novel SAM Competitive PRMT5 Inhibitor, Demonstrating Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance
DCC4096 Pf1070a Natural cyclic tetrapeptide HDAC Inhibitor through the inhibition of PfHDAC1 catalytic activity, potently inducing the synthesis of metallothionein
DCC4097 Pf-184563 Potent, selective non-peptidic antagonist of the V1a receptor
DCC4098 Pf-3604861 Novel dual H3/4 histamine receptor antagonist
DCC4099 Pf-3837 Highly selective, extremely potent Mps1 kinase inhibitor
DCC4100 Pf-4522654 Potent and selective 5-HT2C receptor agonist
DCC4101 Pf-5177624 Selective and potent PDK1 inhibitor inducing anti-tumor activity in breast cancer cells
DCC4102 Pf-543 Hydrochloride Featured Novel, potent and specific inhibitor of sphingosine kinase-1 (SphK1)
DCC4103 pf-5466 Antimalarial, actively against Plasmodium liver stages
DCC4104 Pf-562271 Tosylate Potent, ATP-competitive, reversible inhibitor of FAK

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