| DC11969 |
(S)-C33 |
A novel potent, selective PDE9A inhibitor with IC50 of 11 nM, >45-fold selectivity over other PDE isoforms. |
|
| DC11585 |
MZ-242 |
A novel potent, selective Sirt2 inhibitor with IC50 of 0.118 uM. |
|
| DC11587 |
SirReal1
Featured
|
A novel potent, selective Sirt2 inhibitor with IC50 of 3.745 uM. |
|
| DC21458 |
(S)-PBMC |
A novel potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8). |
|
| DC20951 |
DFL 23448 |
A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold. |
|
| DC21747 |
tBPC |
A novel potent, selective Y4R positive allosteric modulator (EC50=5.1 uM) that potentiates Y4R activation in G-protein signaling and arrestin3 recruitment experiments. |
|
| DC22700 |
DETQ |
A novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM. |
|
| DC11777 |
PDM-631 |
A novel potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively. |
|
| DC22857 |
Pyr-1 |
A novel potent, selective, cell permeable and ATP competitive LIMK inhibitor. |
|
| DC23672 |
Gemigliptin
Featured
|
A novel potent, selective, competitive and orally active DPP4 inhibitor with potential for the treatment of type 2 diabetes. |
|
| DC20685 |
AS2795440 |
A novel potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=2 nM). |
|
| DC20782 |
BI 689648 |
A novel potent, selective, orally active aldosterone synthase inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase. |
|
| DC11730 |
GNE-207 |
A novel potent, selective, orally active CBP/p300 bromodomain with IC50 of 1.0 nM. |
|
| DC22673 |
SCH 486757 |
A novel potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors. |
|
| DC21441 |
ONO-2952 |
A novel potent, selective, orally active translocator protein 18 kDa (TSPO/PBR) antagonist with Ki of 0.33-9.3 nM for both rat and human TSPO. |
|
| DC11536 |
Imigliptin dihydrochloride |
A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM. |
|
| DC11631 |
INCB040093 |
A novel potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM. |
|
| DC22740 |
RO 5126946 |
A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM. |
|
| DC20690 |
ASP 2905
Featured
|
A novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM. |
|
| DC11547 |
LY-2562175
Featured
|
LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM. |
|
| DC21522 |
Balixafortide(POL6326)
Featured
|
Balixafortide(POL 6326) is a novel potent, selective, peptidic CXCR4 antagonist that interferes with the tumor-protective microenvironment and sensitizes tumor cells to chemotherapy. |
|
| DC11826 |
ASP-6537 |
A novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM. |
|
| DC11605 |
ONO-0300302 |
A novel potent, slow tight binding LPA1 receptor antagonist with IC50 of 86 nM, Kd of 0.34 nM. |
|
| DC22600 |
HI-TOPK-032
Featured
|
A novel potent, specific TOPK inhibitor that has no effect on ERK1, JNK1, or p38 kinase activity. |
|
| DC11553 |
FT-827 |
A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain). |
|
| DC23487 |
AS2575959 |
A novel potent, specific, orally available GPR40 agonist that influences glucose-dependent insulin secretion both in vitro pancreas β-cell-derived cells and in vivo. |
|
| DC23450 |
SAS-1121 |
A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 16.2 nM, 574-fold selectivity over sigma 1 receptors.. |
|
| DC23465 |
DKR-1051 |
A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM). |
|
| DC22370 |
Meptyldinocap |
A novel powdery mildew (Erysiphe necator) fungicide that shows protectant and post-infective activities. . |
|
| DC22592 |
Amiselimod hydrochloride (MT-1303 hydrochloride)
Featured
|
A novel prodrug S1P receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators. |
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