| DC11916 |
FD-5180
Featured
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A novel protein kinase affinity probe... |
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| DC11636 |
HMCEF |
A novel P-selectin inhibitor that directly binds to P-selectin. |
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| DC26112 |
SLMP53-1
Featured
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SLMP53-1 is a novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells. |
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| DC11917 |
(R)-OR-S1 |
A novel SAM-competitive, highly selective, orally bioavailable EZH1/2 dual inhibitor with IC50 of 16/50 nM, respectively. |
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| DC25071 |
PDE6δ inhibitor 8 |
A novel selective small molecule inhibitor of PDE6δ/KRas interaction with Kd of 358 pM.. |
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| DC23742 |
Rac1-IN-6 |
A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM. |
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| DC23749 |
Rac1-IN-1 |
A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM. |
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| DC21702 |
SC-99
Featured
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A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src. |
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| DC12010 |
ML116 |
A novel selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM). |
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| DC11527 |
Quilseconazole
Featured
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A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor. |
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| DC12004 |
NS19504 |
A novel selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM. |
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| DC22660 |
Tenovin-D3 |
A novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM. |
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| DC22961 |
ITP-2 |
A novel small molecule activator of Kv 11.1 (hERG) channel (216% over control at 3 uM for hERG1a activation). |
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| DC22982 |
Aldi-6 |
A novel small molecule ALDH inhibitor with IC50 of 600 nM, 800 nM and 1000 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. |
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| DC20650 |
AKI603
Featured
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AKI-603 is a novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; t; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration. |
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| DC23772 |
CMLD-2 |
A novel small molecule disruptor of HuR-mRNA interaction with Ki of 350 nM. |
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| DC11632 |
Cardioprotectant |
A novel small molecule inducer of heme oxygenase-1 that protect human iPSC-derived cardiomyocytes from oxidative stress. |
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| DC25072 |
Deltasonamide 1 |
A novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM. |
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| DC11817 |
Compound L |
A novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay. |
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| DC21679 |
Spindlactone A |
A novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells. |
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| DC21680 |
Spindlactone B |
A novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells. |
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| DC22764 |
CS-11 |
A novel small molecule inhibitor that inhibits PP2A and β-catenin interaction by selectively engaging PR55α binding site (Kd=45 pM). |
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| DC11822 |
YD-277 |
A novel small molecule KLF5 inhibitor derived from ML264, demonstrates >10-fold enhanced efficacy in multiple cancer cell lines with IC50 of 1.5-10 uM. |
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| DC22879 |
YK-3-237 |
A novel small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53. |
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| DC21330 |
MM-206 |
A novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM, binds to the STAT3 coiled-coil domain (CCD). |
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| DC11954 |
JP-153
Featured
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JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.
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| DC20389 |
GATA4 activator 7 |
A novel small molecule that activates GATA4/NKX2-5 transcriptional synergy with EC50 of 7 uM in cell reporter assay. . |
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| DC21039 |
GATA4-IN-3
Featured
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A novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation. |
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| DC11852 |
CTX-1 |
A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation. |
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| DC11669 |
CB-002
Featured
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CB-002 is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells. |
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