| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11865 | DS-5272 | A potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM. |
|
| DC11743 | BMS-681 | A potent and orally bioavailable dual antagonist of CCR2 and CCR5 with binding IC50 of 0.7 nM and 2.4 nM, respectively. |
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| DC22772 | ANI-7 | A potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway. |
|
| DC22622 | WAY-100635 | A potent and selective 5-HT1A receptor antagonist. |
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| DC21471 | PF-03246799 | A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A. |
|
| DC22368 | Alosetron | A potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.. |
|
| DC23952 | GR-79236 Featured | GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals. |
|
| DC20655 | AM-1221 | A potent and selective agonist for the cannabinoid receptor CB1 with Ki of 0.28 nM, 180-fold selectivity over CB2.. |
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| DC22498 | A-443654 Featured | A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1. |
|
| DC23832 | ALK5-IN-16i | A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3. |
|
| DC22583 | AMD-070 hydrochloride(Mavorixafor) Featured | A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay. |
|
| DC22376 | Pitolisant oxalate | A potent and selective antagonist of H3 receptor with Ki/EC50 of 0.16/1.5 nM. |
|
| DC22377 | Pitolisant | A potent and selective antagonist of H3 receptor with Ki/EC50 of 0.16/1.5 nM. |
|
| DC24108 | CCT241533 | A potent and selective ATP-competitive inhibitor of CHK2 K5777:N5777with IC50 of 3 nM. |
|
| DC11654 | VRX-0466617 | A potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM. |
|
| DC22382 | SB-277011 | A potent and selective dopamine D3 receptor antagonist with pKi of 8.0. |
|
| DC22691 | MK-4618 Featured | A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM. |
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| DC22340 | Linaclotide Featured | A potent and selective GC-C agonist (Ki=1.23-1.64 nM) that elicits pharmacological effects locally in the gastrointestinal tract. |
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| DC24162 | Bitopertin R enantiomer | A potent and selective GlyT1 inhibitor with EC50 of 54 nM. |
|
| DC24100 | LY2365109 hydrochloride Featured | A potent and selective GlyT1 inhibitor with IC50 of 15.8 nM, displays no activity for GlyT2 (IC50>30 uM). |
|
| DC11705 | GPR30 inhibitor G1 Featured | A potent and selective GPER/GPR30 agonist with Ki of 11 nM, EC50 of 2 nM. |
|
| DC11672 | G-9791 | A potent and selective group I PAK (pan-PAK1/2/3) inhibitor with Ki of 0.95/2 nM for PAK1/2, respectively. |
|
| DC21716 | T247 | A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8. |
|
| DC21717 | T326 | A potent and selective HDAC3 inhibitor with IC50 of 0.26 uM, with no activity against HDAC1/4/6/8. |
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| DC11596 | SB-379278A | A potent and selective HDAC8 inhibitor with IC50 of 0.5 uM.. |
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| DC11595 | NCC-149 | A potent and selective HDAC8 inhibitor with IC50 of 70 nM. |
|
| DC23214 | ABT-239 | A potent and selective Histamine H3 receptor antagonist with Ki of 0.1-5.8 nM (human, rat H3). |
|
| DC23723 | BMS-711939 | A potent and selective human PPARα agonist with EC50 of 4 nM, >1,000-fold selectivity over human PPARγ (EC50=4.5 uM) and PPARδ (EC50 >100 uM) in PPAR-GAL4 transactivation assays. |
|
| DC23452 | TAK-259 hydrochloride | A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM. |
|
| DC23428 | TAK-259 | A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM. |
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