Potent inhibitor of LpxC

BB-83698 is a peptide deformylase inhibitor and potent antimicrobial with excellent activity against streptococci and Moraxella catarrhalis strains.

Novel inhibitor of SARS-CoV-2 main protease (MPro)

Novel potent apoptotic inducer of human leukaemia cells by activation of the extrinsic pathway and the generation of reactive oxygen species

Novel potent inhibitor of IL-2 secretion, demonstrating potent immunomodulatory activity

Novel FBXO7/PINK1 interaction antagonist, abrogating FBXO7 and PINK1 association, leading to increased cellular PINK1 concentrations and activities, and limiting mitochondrial damage

Memory Enhancer and Free Radical Scavenger

Novel butyrylcholinesterase inhibitor (BChEi) for the treatment of canine cognitive dysfunction

Novel inhibitor of the KRS-67LR interaction

Novel potent and selective degrader of Bcl-2

Novel efficient Bcl-2 inhibitor, exhibiting high specificity and stabilizing effect toward G-quadruplexes

Novel pan-Bcl-2 family inhibitor, upregulating the BH3-only protein Noxa, which inhibits Mcl-1, inducing autophagy through (ER) stress and disruption of the interaction of Beclin 1 with Bcl-2

Novel B-Cell Lymphoma 6 (BCL6) PROTAC

Novel Cell-Permeable Probe for the Identification of Protein Sulfenic Acids

Clearing cycloalkyne for click reaction with Azido-Warfarin WN3 or other Azido-containing drugs

Novel highly potent inhibitor of breakpoint cluster region-abelson kinase (Bcr-Abl) including the T315I mutant

Novel Bcr-Abl inhibitor, potently inhibited Bcr-AblWT and Bcr-AblT315I kinases with IC 50 of 0.043 μM and 0.17 μM, respectively

Potent and selective

Novel small molecule PTP1B inhibitor

Sodium channel enhancer

Potent and selective hydroxamate PfAM1 inhibitor

Novel EthR inhibitor, boosting antituberculous activity of ethionamide