| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC12638 | KBP-5074 | KBP-5074 (KBP5074) is a novel non-steroidal, highly selective mineralocorticoid receptor antagonist for the treatment of hypertensive chronic kidney disease.. |
|
| DC20621 | KC01 | KC01 is a potent and selective inhibitor of ABHD16A with IC50 of 90 nM for hABHD16A, 520 nM for mABHD16A. |
|
| DC12416 | KCI807 | KCI807 (KCI-807) is a lead molecule that selectively disrupts ELK1-dependent promoter activation by wild-type and variant Ars (IC50=0.53 uM) without interfering with ELK1 activation by ERK. |
|
| DC7871 | KCL-440 | KCL-440 is a a new poly(ADP-ribose) polymerase- PARP inhibitor. |
|
| DC12615 | KCN1 | KCN1 (HIF inhibitor KCN1) is a small molecule inhibitor of the HIF-1 pathway, antagonizes HIF transcription in bioassay, blocks the p300/HIF-1α interaction, and exert potent anticancer activity in vitro and in vivo. |
|
| DC12519 | KDM5A covalent inhibitor N71 | KDM5A covalent inhibitor N71 is an irreversible KDM5A inhibitor (IC50=0.22 uM) that covalently interacts with Cys481, >20-fold selectivity over KDM4A.. |
|
| DC12520 | KDM5A covalent inhibitor N73 | KDM5A covalent inhibitor N73 is the the isopropyl ester derivative of N71, an irreversible KDM5A inhibitor (IC50=0.22 uM) that covalently interacts with Cys481, >20-fold selectivity over KDM4A.. |
|
| DC23375 | KDM5-C49 | KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively. |
|
| DC23376 | KDM5-C70 Featured | KDM5-C70 is the cell-permeable derivative of KDM5-C49, potent, selective and cell permeable KDM5 inhibitor with IC50 of 0.3, 0.3 and 0.58 uM for KDM5A, B and C, respectively. |
|
| DC10285 | KDM5-IN-1 Featured | KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM. |
|
| DC23369 | KDM-IN-6 | KDM-IN-6 is a potent, highly selective and cell-active inhibitor of KDM2A/7A with IC50 of 0.16 and 0.19 uM,respectively. |
|
| DC23673 | KDS2010 | KDS2010 (KDS-2010, KDS 2010) is a potent, highly selective, reversible Monoamine oxidase-B (MAO-B) inhibitor with IC50 of 7.6 nM. |
|
| DC23778 | KDU731 | KDU731 is a potent, selective parasite Cryptosporidium lipid kinase PI4K (phosphatidylinositol-4-OH kinase) inhibitor with IC50 of 25 nM, displays >50-fold selectivity window against the human PI4K IIIβ homologue. |
|
| DC11627 | KEA1-97 Featured | KEA1-97 (KEA 1-97) is a small molecule that disrupts the interaction of thioredoxin with caspase 3. |
|
| DC12272 | Kelatorphan | Kelatorphan is a full inhibitor of enkephalin degrading enzymes. |
|
| DC21200 | KG-548 | KG-548 is an ARNT/TACC3 disruptor (IC50=25 uM) that selectively bind within the ARNT PAS (Per-ARNT-Sim) domain that recruits TACC3.. |
|
| DC22752 | KGA-2727 Featured | KGA-2727 is a potent, selective SGLT1 inhibitor with Ki of 97.4 nM, >100-fold selectivity over SGLT2. |
|
| DC23680 | KGP-420 | KGP-420 is the water-soluble phosphate prodrug of KGP-94 in vivo studies, KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM. |
|
| DC23674 | KGP-94 | KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM, shows no significant inhibitory effect on cathepsin B (IC50>10 uM). |
|
| DC22230 | KH-176 | KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system. |
|
| DC21201 | KH 176 | KH176 is a chemical entity derivative of Trolox and small molecule ROS-redox modulator, shows potential treatment for mitochondrial disorders. |
|
| DC20009 | KH7 Featured | KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. |
|
| DC25101 | KH-CB19 | KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform. |
|
| DC23106 | KHK-IN-8 | KHK-IN-8 is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK, also shows potent cellular KHK inhibition with IC50 of <500 nM.. |
|
| DC25105 | KHK-IN-8 hydrochloride | KHK-IN-8 is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK, also shows potent cellular KHK inhibition with IC50 of <500 nM.. |
|
| DC12275 | KHS101 hydrochloride Featured | KHS101 hydrochloride could selectively induce a neuronal differentiation phenotype and interacts with transforming acidic coiled-coil-containing protein 3 (TACC3). |
|
| DC21202 | KI16 | KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain. |
|
| DC20431 | Kif15-IN-1 | Kif15-IN-1 is a potent, selective inhibitor of KIF15 motility, can act synergistically with Eg5 inhibitors to impair cancer cell proliferation.. |
|
| DC20432 | KIN-281 | KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively. |
|
| DC12220 | Kinesore | Kinesore is an inhibitor of the KLC2-SKIP Interaction. |
|
