| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23633 | LY 392098 | LY 392098 is a selective, potent and centrally active positive allosteric modulator of AMPAR. |
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| DC7189 | LY-2109761 | LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2. |
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| DC2045 | LY2183240 | LY2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). |
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| DC12130 | LY223982 | LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. |
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| DC23720 | LY2452473 Featured | LY2452473 is an orally bioavailable, selective androgen receptor modulator (SARM). |
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| DC24072 | LY-2584702 free base Featured | LY2584702 is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM. |
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| DC24073 | LY-2584702 hydrochloride Featured | LY2584702 is a potent, selective, ATP-competitive inhibitor of P70S6 kinase-1 (p70S6K1) with IC50 of 4 nM. |
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| DC22140 | LY2623091 | LY2623091 (LY-2623091) is an orally administered mineralocorticoid receptor antagonist for the treatment of essential hypertension and chronic kidney disease.. |
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| DC23444 | LY2624803 | LY2624803 is a novel potent histamine H1 and 5HT-2A receptor modulator in the pipeline for treating insomnia.. |
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| DC7665 | Gandotinib(LY2784544) Featured | LY2784544 is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2. |
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| DC23510 | LY2794193 Featured | LY2794193 is a highly potent and selective mGlu3 receptor agonist with Ki of 0.93 nM and EC50 of 47 nM, >100-fold selectivity over mGlu2 receptor.. |
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| DC22595 | LY2857785 | LY2857785 is a potenrt, reversible and ATP-competitive CDK9 inhibitor with IC50 of 11 nM, also inhibits CDK8 (IC50=16 nM) and weakly inhibits CSK7 (IC50=246 nM). |
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| DC11681 | LY2922470 | LY2922470 (LY-2922470) is a potent, selective, orally available GPR40 agonist with EC50 of 7 nM. |
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| DC21340 | LY 2979165 | LY2979165 (MP-101) is the alanine prodrug of LY2812223, a selective orthosteric mGlu2 receptor agonist. |
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| DC23688 | LY-3000328 Featured | LY 3000328 is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively. |
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| DC7210 | LY-303511(Nv-128) Featured | LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K. |
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| DC7776 | LY-3039478 | LY3039478 a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. |
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| DC23718 | LY305 | LY305 (LY-305) is a non-steroidal selective androgen receptor modulator (SARM) with Ki of 2.03 nM, demonstrates potent agonist activity in the aforementioned C2C12 cellular assay (EC50=0.499 nM). |
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| DC21259 | LY 3130481 Featured | LY3130481 (CERC611) is a potent, selective, noncompetitive TARP γ8-associated AMPA receptors with IC50 of 65.3 nM (GluA1/TARP γ-8), with no activity for γ-2 (cerebellum) or other TARP members. |
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| DC12507 | LY3143921 | LY3143921 (LY-3143921) is an orally available, potent, selective inhibitor of Cdc7 kinase inhibitor, inhibits CDC7/DBF4 I and pMCM2 (S53) with IC50 values of 3.3 nM and 290 nM, respectively.. |
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| DC11330 | LY320135 Featured | LY320135 is a selective cannabinoid (CB) receptor 1 antagonist (Kis = 224 and >10,000 nM for CB1 and CB2, respectively, in vitro). |
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| DC21253 | N-(3-((4aR,7aS)-2-amino-6-(5-fluoropyrimidin-2-yl)-4a,5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a(4H)-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide Featured | LY3202626 is a small molecule non-selective BACE1 inhibitor, causes dose-dependent reductions in CSF and plasma Aβ concentrations, shows potential for the treatment of Alzheimer's disease.. |
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| DC10640 | LY3214996 Featured | LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. |
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| DC12261 | LY3295668 (AK-01) | LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. |
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| DC9314 | LY 344864 | LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. |
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| DC22784 | LY-345899 Featured | LY-345899 (LY345899) is a novel potent, cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with IC50 of 96 nM and 663 nM, respectively; MTHFD2 is a novel target for drug development. |
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| DC11323 | LY354740 | LY354740 is an agonist of the group II metabotropic glutamate receptor (mGluR) subtypes mGluR2 and mGluR3 (Kis = 99 and 94 nM, respectively). |
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| DC23829 | LY379196 | LY379196 is a highly specific PKCβ inhibitor with IC50 of 30-50 nM for PKCβI and PKCβII, displays >10-fold selectivity of PKCα, δ, η, and γ (>600 nM). |
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| DC23597 | LY-404187 | LY-404187 is a potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 1.3 uM. |
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| DC22435 | LY487379 Featured | LY-487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3; shows no intrinsic agonist or antagonist activity at hmGluR2, markedly potentiates glutamate-stimulated [35S]GTPgammaS binding at hmGluR2; potentiates synaptically evoked mGluR2 responses in rat hippocampal slices, modulates excitatory synaptic transmission in the rat globus pallidus. |
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