| DC20443 |
MARPIN |
MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM. |
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| DC7460 |
Masitinib
Featured
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Masitinib is a broad coronavirus 3CL inhibitor that effectively blocks replication of SARS-CoV-2. Science 20 Jul 2021: eabg5827 DOI: 10.1126/science.abg5827 |
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| DC11236 |
MB-07811 (VK-2809)
Featured
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MB-07811 (VK-2809) is an orally bioavailable, liver-targeted prodrug of MB07344, which is a thyroid hormone receptor-beta agonist (TRβ) agonist, efficiently converted to MB07344 by liver microsomes in vivo. |
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| DC10958 |
MB710 |
MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.. |
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| DC10957 |
MB725
Featured
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MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM). |
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| DC12094 |
MBQ-167 |
MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively. |
|
| DC21270 |
MC-1575 |
MC-1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A, displays >70-fold selectivity over HD1-B. |
|
| DC23370 |
MC2884 |
MC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively. |
|
| DC11358 |
CPP32 Fluorogenic Substrate III |
Mca-DEVDAPK(Dnp)-OH is a substrate for caspase-3. |
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| DC11338 |
MMP-2/MMP-7 Fluorogenic Substrate Control
Featured
|
Mca-PL is a fluorogenic peptide that has been used as a building block in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. |
|
| DC8550 |
MCB-613
Featured
|
MCB-613 is a novel and potent stimulator of p160 steroid receptor coactivators (SRCs). It is a Pan-SRCs stimulator. |
|
| DC23706 |
Netoglitazone(MCC 555)
Featured
|
Netoglitazone, also known as isaglitazone and MCC-555, is an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic activity. Netoglitazone exerts both peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist activity. Netoglitazone decreases bone formation and increases marrow adipocyte formation in vivo.MCC 555 (Isaglitazone. |
|
| DC26085 |
MCL0129 |
MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3. |
|
| DC22643 |
Mcl1-IN-2 |
Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.. |
|
| DC20444 |
Mcl-1-Puma inhibitor 8 |
Mcl-1-Puma inhibitor 8 is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis. |
|
| DC10353 |
MCOPPB triHydrochloride |
MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors. |
|
| DC23820 |
MCP110
Featured
|
MCP110 is a potent Ras/Raf-1 interaction inhibitor. |
|
| DC23644 |
MCT1-IN-4a |
MCT1-IN-4a is a potent, selective monocarboxylate transporter 1 (MCT1) inhibitor with IC50 of 90 nM. |
|
| DC7841 |
MDA 19 |
MDA 19 is a selective human CB2 receptor agonist with Ki of 43.3 nM. |
|
| DC12581 |
MDI-2268
Featured
|
MDI-2268 (MDI2268) is a small-molecule, in vivo-active inhibitor of plasminogen activator inhibitor type-1 (PAI-1), demonstrates excellent pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and efficacy in murine model of venous thrombosis. |
|
| DC23739 |
Meayamycin |
Meayamycin is an analogue of FR901464 that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, shows picomolar antiproliferative activity against various cancer cell lines and multidrug-resistant cells.. |
|
| DC10258 |
Mebendazole |
Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking g |
|
| DC7757 |
(R)-Meclizine |
Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness. |
|
| DC20446 |
Mefuparib hydrochloride(CVL218)
Featured
|
Mefuparib(CVL218) hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively.CVL218 was more potent than Remdesivir in blocking Coronavirus infection of cells and equally as potent as Remdesivir in blocking replication of virus once it has entered the cells. |
|
| DC26032 |
Melagatran |
Melagatran is a synthetic, small-peptide direct thrombin inhibitor with anticoagulant activity. |
|
| DC11083 |
Dersimelagon
Featured
|
Dersimelagon, also known as MT-7117 and WHO 10832, is a novel, orally-administered, small molecule, selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients. Dersimelagon significantly boosted sunlight tolerance in patients with erythropoietic protoporphyria in a multicenter, phase 2, randomized trial.
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| DC11353 |
MIF-1 |
Melanocyte-stimulating hormone release-inhibiting factor (MSH-R-IF) is a hypothalamic tripeptide that binds to rat striatum (Kd = 4.69 nM) and has diverse biological activities. |
|
| DC8311 |
Meleagrin |
Meleagrin is an antibiotic derived from a deep ocean, penicillin-producingP. chrysogenum. |
|
| DC21274 |
Melflufen |
Melflufen (Melphalan flufenamide, J1) is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo. |
|
| DC21917 |
MELK inhibitor 17 |
MELK inhibitor 17 is a potent, selective MELK inhibitor with Ki/IC50 of 0.39/3 nM, >100-fold selectivity over CHK1, CAMKK2, NUAK1 and ERK2. |
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