| DC23592 |
GI-530159 |
GI-530159 (ICA-069771) is a novel potent, selective, mechano-sensitive K2P channel (TERK) opener with EC50 of 1 uM for TERK1. |
|
| DC10490 |
GIBH-130
Featured
|
GIBH-130 is a novel inhibitor of neuroinflammation effective in Alzheimer’s disease models. |
|
| DC8946 |
Gimeracil |
Gimeracil(Gimestat) is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood; inhibits homologous recombination. |
|
| DC10081 |
GJ103
Featured
|
GJ103 is an active analog of the read-through compound GJ072. |
|
| DC22099 |
GK563 |
GK563 (GK-563) is a potent, selective inhibitor of Ca2+-independent phospholipase A2 (GVIA iPLA2) with IC50 of 1 nM, >20,000-fold selectivity over GIVA cPLA2. |
|
| DC9855 |
GK921
Featured
|
GK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 uM in cancer cell lines. |
|
| DC20087 |
GKI-1 |
GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 µM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 µM, but only weakly affected PKA. |
|
| DC23332 |
GL-1196 |
GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression. |
|
| DC21049 |
Glabrescione B
Featured
|
Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction, inhibits Hh signaling by impairing Gli1 function; inhibits the growth of Hedgehog-dependent tumor cells in vitro and in vivo, inhibits Gli1-dependent growth of cerebellum-derived normal progenitors; inhibits the growth of Gli-dependent medulloblastoma and tumor-derived stem-like cells; inhibits the growth of Gli-dependent basal cell carcinoma in vitro and in vivo. |
|
| DC10130 |
Glabridin
Featured
|
Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract |
|
| DC22566 |
Glesatinib hydrochloride |
Glesatinib (MGCD-265) is a tyrosine kinase inhibitor that potently and selectively inhibits Met and Axl kinase.. |
|
| DC25053 |
Glesatinib |
Glesatinib (MGCD-265) is a tyrosine kinase inhibitor that potently and selectively inhibits Met and Axl kinase.. |
|
| DC9158 |
Glimepiride |
Glimepiride(Amaryl) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg. |
|
| DC9146 |
Glipizide |
Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. |
|
| DC12257 |
Gln-AMS TFA |
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 µM. |
|
| DC12354 |
Gln-AMS |
Gln-AMS is an aminoacyl-tRNA synthetases (AARS) inhibitor, which binds the A-domain within the NRPS enzymes. |
|
| DC12223 |
GLP-1 receptor agonist-1 |
GLP-1 receptor agonist-1 is a glucagon-like peptide-1 receptor (GLP-1R) agonist. |
|
| DC10319 |
GLP-17-3 |
GLP-1(7-36) is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells. |
|
| DC21051 |
GLPG 0974 |
GLPG 0974 is a potent, selective free fatty acid receptor 2 (FFA2, GPR43) antagonist with IC50 of 95 nM. |
|
| DC26048 |
GLS1 Inhibitor
Featured
|
GLS1 inhibitor is an inhibitor of glutaminase 1 |
|
| DC21052 |
GLS 4(Morphothiadin)
Featured
|
GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24 nM) and reduces HBV-DNA levels in HepG.2.2.15 cells (IC50=14 nM), shows efficacy against ADV-resistant HBV mutations. |
|
| DC20026 |
Glucokinase activator 1 |
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM. |
|
| DC8973 |
D-Glucosamine hydrochloride |
Glucosamine (hydrochloride) is a natural product. |
|
| DC9529 |
Glutaminase C-IN-1
Featured
|
Glutaminase C-IN-1 (968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts. |
|
| DC12236 |
Glycodeoxycholate Sodium |
Glycodeoxycholate Sodium is a bile salt. |
|
| DC12082 |
Glycodeoxycholic acid monohydrate |
Glycodeoxycholic acid monohydrate is a nuclear receptor ligand. |
|
| DC12229 |
Glycogen |
Glycogen is a glycolytic intermediates and high-energy phosphates that can serve as a form of energy storage in humans, animals, fungi, and bacteria. |
|
| DC20889 |
Glycopyrronium bromide |
Glycopyrronium bromide (CHF 5259) is a peripherally-acting quaternary ammonium antimuscarinic agent with little or no central nervous system activity. |
|
| DC11454 |
Gly-Pro-pNA
Featured
|
Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). |
|
| DC20113 |
Gly-β-MCA |
Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders. |
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