| DC20406 |
HIF2α-IN-2 |
HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM, shows high selectivity and does not affect HIF-1 function. |
|
| DC7148 |
LY 379268
Featured
|
Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. |
|
| DC20083 |
H-Ile-Pro-Pro-OH
Featured
|
H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. Antihypertensive tripeptides. |
|
| DC23298 |
Hinokitiol |
Hinokitiol (4-Isopropyltropolone. |
|
| DC23710 |
Hippuristanol |
Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A), results in cell cycle arrest at G1 phase, and induces caspases activation and apoptosis. |
|
| DC10585 |
Hispidol
Featured
|
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM. |
|
| DC8163 |
Fostemsavir(BMS-663068)
Featured
|
HIV-1 attachment inhibitor,a prodrug of the small-molecule inhibitor BMS-626529 |
|
| DC23258 |
HIV-1 inhibitor 18A |
HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM. |
|
| DC23263 |
HIV-1 Integrase Inhibitor 7 |
HIV-1 Integrase Inhibitor 7 is an allosteric HIV-1 integrase inhibitor that inhibits the LEDGF/p75-integrase interaction with IC50 of 0.58 uM, antiviral activity EC50 of 0.76 uM.. |
|
| DC21116 |
HJC0197
Featured
|
HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP. |
|
| DC21118 |
HJC 0726 |
HJC 0726 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM. |
|
| DC21117 |
HJC-0338 |
HJC-0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2. |
|
| DC7638 |
HJC-0350
Featured
|
HJC-0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells. |
|
| DC21119 |
HL001 |
HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression. |
|
| DC21977 |
HlyU inhibitor CM14 |
HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30. |
|
| DC10414 |
HM30181(Encequidar)
Featured
|
HM30181 is a potent and selective inhibitor of P-glycoprotein. |
|
| DC12074 |
HM30181 mesylate
Featured
|
HM30181 mesylate is a competitive and potent P-glycoprotein inhibitor. |
|
| DC10517 |
HMN-154
Featured
|
HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively. |
|
| DC9957 |
HMN-176
Featured
|
HMN-176 is a stilbene derivative which inhibits mitosis without significant effect on tubulin polymerization. |
|
| DC20407 |
HMPC |
HMPC is a novel bacteriostatic agent that shows bacteriostatic activity against S. aureus (MIC=4 μg/ml) and rescues Caenorhabditis elegans from S. aureus infection. |
|
| DC22107 |
HMS-101 |
HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively). |
|
| DC6314 |
Icatibant acetate
Featured
|
HOE-140 (Icatibant) is a potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM). |
|
| DC9415 |
Hoechst 33342 (trihydrochloride) |
Hoechst 33342 3Hcl(HOE 33342 3Hcl) is an AT-specific DNA minor groove ligand used fluorochrome for visualizing cellular DNA. |
|
| DC9418 |
Hoechst 33258 analog |
Hoechst stains are part of a family of blue fluorescent dyes used to stain DNA.
|
|
| DC22129 |
HOIPIN-1(JTP-0819958;HOIP inhibitor-1)
Featured
|
HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the N |
|
| DC22108 |
HOIPIN-8
Featured
|
HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pa |
|
| DC9650 |
Homoharringtonine
Featured
|
Homoharringtonine(HHT) is a cytotoxic alkaloid from the evergreen tree. |
|
| DC10177 |
Homoplantaginin |
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinfammatory and antioxidant properties. |
|
| DC5908 |
Honokiol
Featured
|
Honokiol(NSC-293100), a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis, has been reported to have anticancer activities in a variety of cancer cell lines. |
|
| DC12154 |
Hosenkoside A |
Hosenkoside A is a baccharane glycoside isolated from the seeds of impatiens balsamina. |
|
