| DCAPI1242 |
Isoniazid(Tubizid)
Featured
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Isoniazid is an antibacterial agent used primarily as a tuberculostatic.Target: AntibacterialIsoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG [1]. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824 [2, 3]. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing [4]. |
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| DC20215 |
Isonicotinic acid; Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid |
Isonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. |
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| DC12147 |
Isoquercitrin (Isoquercitroside; Isoquercetin) |
Isoquercitrin is an effective antioxidant and an eosinophilic inflammation suppressor. |
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| DC23107 |
ISOQUERCITRIN
Featured
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Isoquercitrin is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation; it is also a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. |
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| DC23018 |
Isoscopoletin
Featured
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Isoscopoletin possesses inhibitory activity against hepatitis B virus (HBV) replication; it also shows substantial inhibition against multi-drug resistant CEM/ADR5000 cells and human CCRF-CEM leukaemia cells, with the IC50 value is 1.6 and 4.0 microM, res |
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| DC23053 |
Isosilybin
Featured
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Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities.It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lac |
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| DC8960 |
Isosorbide 5-mononitrate |
Isosorbide mononitrate(Isosorbide-5-mononitrate) is a nitrate-class compound used for angina pectoris; acts by dilating the blood vessels so as to reduce the blood pressure. |
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| DC9824 |
Isosteviol
Featured
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Isosteviol is a derivative of stevioside, a constituent of Stevia rebaudiana, which is commonly used as a noncaloric sugar substitute in Japan and Brazil. |
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| DC12069 |
Isotanshinone I |
Isotanshinone I has inhibitory activity against α-glucosidase and formation of AGE, with IC50s of 1.13, 0.432 μM for α-glucosidase and AGE, respectively. |
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| DC12066 |
Isotanshinone IIA |
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. |
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| DC21434 |
Isothiafludine |
Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM. |
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| DC9039 |
Isotretinoin |
Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. |
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| DC23095 |
ISOVITEXIN
Featured
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Isovitexin, a food phytochemical contained in dietary rice products, it exhibits in vivo α-glucosidase inhibition, it possesses antihyperglycemic, neuroprotective, anti-inflammatory and anti-oxidant activities. Isovitexin inhibited xanthine oxidase with a |
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| DC8772 |
Isradipine
Featured
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Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM. |
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| DC12393 |
iST2-1 |
iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively. |
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| DC22333 |
iST2-2
Featured
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iST2-2 is a novel ST2 (suppression of tumorigenicity 2) inhibitor active in vivo. |
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| DC7151 |
Istaroxime(PST2744) |
Istaroxime(PST2744) is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). |
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| DC7845 |
Istaroxime hydrochloride(PST2744) |
Istaroxime(PST2744) is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). |
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| DC10898 |
Protein kinase inhibitor 1
Featured
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It is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM. |
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| DC23662 |
ITI214 free base
Featured
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ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
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| DC23687 |
ITI214 |
ITI-214 is a potent, selective, orally active phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
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| DC21156 |
ITX-5061 |
ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels. |
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| DC21157 |
ITX-5061 hydrochloride
Featured
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ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels. |
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| DC22795 |
ITZ-1 |
ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation. |
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| DC26005 |
IU1
Featured
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IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. |
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| DC23797 |
IU1-47
Featured
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IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons. |
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| DC3153 |
Ivabradine hydrochloride
Featured
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Ivabradine, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. |
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| DC24117 |
Ivacaftor benzenesulfonate |
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
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| DC24116 |
Ivacaftor hydrate |
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
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| DC20203 |
IWP-O1 |
IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells. |
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