| DC9275 |
Mirin
Featured
|
Mirin is a Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. |
|
| DCAPI1458 |
Miriplatin |
Miriplatin |
|
| DC23113 |
Mirk-IN-1
Featured
|
Mirk-IN-1 is a potent, specific inhibitor of Dyrk1B (Mirk kianse) and Dyrk1A with IC50 of 68 nM and 22 nM respectively, shows SW620 cell IC50 of 1.9 uM. |
|
| DCAPI1370 |
Mirtazapine (Remeron, Avanza) |
Mirtazapine (Remeron, Avanza) |
|
| DC20452 |
MitoBloCK 1 |
MitoBloCK 1 is a small molecule inhibitor that blocks the import of substrates that use the TIM22 import pathway, but not TIM23 or the Mia40/Erv1 translocation pathways. |
|
| DC12625 |
MitoBloCK-10
Featured
|
MitoBloCK-10 (MB-10) is a potential attenuator of protein import into mitochondria via targeting Tim44, inhibits the import of substrates that use the TIM23 import pathway. |
|
| DC12626 |
MitoBloCK-11
Featured
|
MitoBloCK-11 (MB-11) is a s mall molecule inhibitor of mitochondrial protein import possibly acts through transport protein Seo1, but not Tom70 or Tom20; inhibits precursor proteins that contain hydrophobic segments, confers growth in media lacking uracil in a specific manner and affects zebrafish development. |
|
| DCAPI1234 |
Mitotane (Lysodren) |
Mitotane (Lysodren) |
|
| DC12364 |
Mito-TEMPO
Featured
|
Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic with superoxide and alkyl radical scavenging properties. |
|
| DCAPI1315 |
Mitoxantrone HCl |
Mitoxantrone HCl |
|
| DC21279 |
MIV-247 |
MIV-247 (MIV247) is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S). |
|
| DC22150 |
MIV-711 |
MIV-711 (MIV711, MV076159) is a potent, selective cathepsin K inhibitor with Ki of 0.98 nM, displays >1300-fold versus the other human cathepsins. |
|
| DC20978 |
Mizagliflozin
Featured
|
Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2. |
|
| DC9011 |
Mizoribine
Featured
|
Mizoribine(NSC 289637; HE 69; β-Bredinin) is an immunosuppressive agents (IC50=100 uM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH. |
|
| DC21282 |
MJN110
Featured
|
MJN110 (MJN-110) is a potent, selective, and orally active MAGL inhibitor with IC50 of 2.1 nM (2-AG hydrolysis). |
|
| DC21283 |
MJN-228 |
MJN-228 is a selective ligand for the lipid-binding protein nucleobindin 1 (NUCB1) with IC50 of 3.3 uM (blocks AEA-DA probe labeling of NUCB1). |
|
| DC23419 |
MK-0249 |
MK-0249 is a novel potent, selective histamine H3 inverse agonist for the treatment of cognitive impairment with schizophrenia.. |
|
| DC23658 |
MK-0343 |
MK-0343 (MRK-409) is a potent, α2/3 subtype selective, partial GABAA receptor agonist, shows greater agonist efficacy at the α3 over α1 subtypes. |
|
| DC21289 |
MK-0429 |
MK-0429 is a potent, selective, orally-active nonpeptide αvβ3 integrin inhibitor with IC50 of 0.08 nM in SPAV3 assay. |
|
| DC21290 |
MK-0448 |
MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM. |
|
| DC23665 |
MK-0674 |
MK-0674 is a potent, selective, reversible and orally active cathepsin K inhibitor with IC50 of 1 nM. |
|
| DC23343 |
MK-0731 |
MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM. |
|
| DC21293 |
MK-1 |
MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation. |
|
| DC23650 |
MK-1832 |
MK-1832 is a potent, selective Kv1.5 inhibitor with IC50 of 86 nM, exhibits improved selectivity for IKur over IKs (>3000-fold) compares with MK-0448 (70-fold), also exhibits an improved preclinical pharmacokinetic profile.. |
|
| DC26086 |
MK-1925 |
MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1. |
|
| DC21296 |
MK-204 |
MK-204 is a potent, selective AKR1B10 inhibitor with IC50 of 80 nM, shows high selective (270-fold) over AKR1B1. |
|
| DC23099 |
MK-2048 |
MK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively. |
|
| DC24121 |
MK2-IN-1 |
MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM. |
|
| DC24120 |
MK2-IN-1 hydrochloride
Featured
|
MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM. |
|
| DC21297 |
MK-3281 |
MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM. |
|
