| DC22670 |
R243
Featured
|
R243 is a potent, small molecule CCR8 antagonist that inhibits CCR8 signaling and chemotaxis, inhibits CCL1-induced Ca2+ flux and CCL1-driven peritoneal macrophages aggregation at 0.2 uM. |
|
| DC21551 |
R-360163 |
R-360163 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 16 uM in FP assay. |
|
| DC7258 |
Bemcentinib（R428，BGB324)
Featured
|
R428 is a potent and selective small-molecule inhibitor(IC50=14 nM), blocks the activities of Axl. |
|
| DC10897 |
R-7050
Featured
|
R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα. |
|
| DC21555 |
R-999636 |
R-999636 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 8.8 uM in FP assay. |
|
| DC9103 |
Rebeprazole sodium |
Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors. |
|
| DC21544 |
rac Pterosin B |
rac Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain. |
|
| DC20528 |
RAD51-IN-1
Featured
|
RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines. |
|
| DC21069 |
Radalbuvir |
Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b. |
|
| DC9351 |
Radezolid
Featured
|
Radezolid (RX-1741) is a novel oxazolidinone antibiotic agent.
|
|
| DC12701 |
Radiprodil
Featured
|
Radiprodil is an orally active and selective NMDA NR2B antagonist; a potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions. |
|
| DC8011 |
Radotinib (IY-5511)
Featured
|
Radotinib(IY-5511) is a novel and selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM for wild-type BCR-ABL1 kinase. |
|
| DC10899 |
Ralinepag
Featured
|
Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively. |
|
| DC9166 |
Raloxifene HCl |
RaloxifeneHcl(LY156758 Hcl) is a second generation selective estrogen receptor antagonist. |
|
| DC6918 |
Ramatroban (BAY u3405) |
Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
|
| DCAPI1391 |
Ranolazine (Ranexa)
Featured
|
Ranolazine (Ranexa) |
|
| DC12624 |
RAS activator compound 1
Featured
|
RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM; targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2. |
|
| DCAPI1486 |
Rasagiline Mesylate |
Rasagiline Mesylate is an antiparkinsonian and a selective irreversible MAO-B inhibitor. |
|
| DC21526 |
Ravidasvir free base
Featured
|
Ravidasvir (PPI-668;BI 238630) is a potent pan-genotypic HCV NS5A inhibitor with IC50 of 0.12/0.01/1.14 nM for HCV gt-1a/1b/3a in replicon luciferase assay; |
|
| DC21558 |
RB-101 |
RB-101 is an mixed enkephalinase inhibitor that inhibits Aminopeptidase N and Neutral Endopeptidase with IC50 of 11 nM and 2 nM, respectively. |
|
| DC8143 |
RBC8
Featured
|
RBC8 is a novel small molecule inhibitor of Ral GTPase; has IC50 of 3.5 μM in H2122 cell and 3.4 μM in H358 cell. |
|
| DC11468 |
Rbin-1
Featured
|
Rbin-1 is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis. Rbin-1 inhibits the ATPase with GI50 of 136±7 nM. |
|
| DC21559 |
RBPI-4 |
RBPI-4 is a selective small molecule inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with IC50 of 3.0 uM, effectively inhibit PARG in cellular lysate.. |
|
| DC12307 |
RCGD423
Featured
|
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair. |
|
| DC11135 |
RCM-1 |
RCM-1 (FOXM1 inhibitor RCM-1) is a nontoxic, small molecule that inhibits FOXM1 activity in vitro and in vivo, inhibits GFP-FOXM1 in U2OS cells with EC50 of 0.72 uM. |
|
| DC9739 |
ReACp53（TFA salt）
Featured
|
ReACp53 is a cell-penetrating peptide,designed to inhibit p53 amyloid formation. |
|
| DC9570 |
Rebaudioside C
Featured
|
Rebaudioside C(Dulcoside B) is used as natural sweeteners to diabetics and others on carbohydrate-controlled diets. |
|
| DC23821 |
REDX-05358 |
REDX-05358 is a novel potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively. |
|
| DC22597 |
Regorafenib hydrochloride
Featured
|
Regorafenib hydrochloride (BAY73-4506) is a potent, orally active multikinase inhibitor that potently inhibits endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM). |
|
| DC21615 |
Relacatib |
Relacatib (SB-462795, GSK-462795) is a potent and orally bioavailable small molecule cathepsin inhibitor with Ki of 41, 68 and 53 pM for cathepsin K, L and V, respectively. |
|
