| DC12385 |
Relugolix(TAK-385)
Featured
|
Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013. |
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| DC20529 |
Remodelin Fluor |
Remodelin Fluor is a small molecule analog of Remodelin, demonstrates in vivo activitiy against NAT10, significantly enhances the healthspan in a Lmna G609G HGPS mouse model.. |
|
| DCAPI1444 |
Repaglinide |
Repaglinide is a KIR6 (KATP) channel blocker that binds with high affinity for SUR1 when co-expressed with KIR6.2(Kd = 0.42 nM). |
|
| DC8235 |
Repinotan (BAYx3702) |
Repinotan is a high-affinity, selective, full agonist of the 5HT1A-receptor subtype with neuroprotective properties. |
|
| DC7788 |
Resiquimod（R848）
Featured
|
Resiquimod (R-848; S28463) is a potent synthetic agonist of TLR7/TLR8 that possesses antiviral and antitumoral activities. |
|
| DC21561 |
BT-13 |
RET agonist BT13 is a novel small molecule GDNF receptor RET agonist, potently and selectively activates RET and its downstream intracellular signaling cascades in immortalized cells (EC50~20 uM). |
|
| DC2089 |
Retigabine
Featured
|
Retigabine is a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. |
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| DC20530 |
RET-IN-23c |
RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR. |
|
| DC12234 |
Retinyl palmitate (Vitamin A palmitate; Retinol palmitate) |
Retinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in pharmaceutical and cosmetic formulations. |
|
| DC23293 |
RETRA hydrobromide |
RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
|
| DC23287 |
RETRA hydrochloride |
RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
|
| DC23312 |
RETRA |
RETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
|
| DC20531 |
Retro 1 |
Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface. |
|
| DC20532 |
Retro 2 |
Retro 2 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface. |
|
| DC20533 |
Rev1-IN-5 |
Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM. |
|
| DC21616 |
Revaprazan |
Revaprazan (SB-641257. |
|
| DC21617 |
Revaprazan hydrochloride |
Revaprazan (SB-641257. |
|
| DC7260 |
Reversine
Featured
|
Reversine, a small synthetic purine analogue (2,6-disubstituted purine), is a potent inhibitior of Aurora A/B/C with IC50s of 150-500 nM. |
|
| DC21696 |
Revexepride |
Revexepride (SSP 002358. |
|
| DC7584 |
RG108
Featured
|
RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes. |
|
| DC7821 |
Idasanutlin (RG-7388)
Featured
|
RG7388 is an oral, selective, small molecule MDM2 antagonist that inhibits binding of MDM2 to p53. |
|
| DC20005 |
RG7834 (RO 7020322)
Featured
|
RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells. |
|
| DC10719 |
RGX-104
Featured
|
RGX-104 is an orally bioavailable agonist of the nuclear receptor liver X receptor beta (LXRbeta; NR1H2; LXR-b), with potential immunomodulating and antineoplastic activities. |
|
| DC21564 |
RH01386 |
RH01386 is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. |
|
| DC21565 |
RH01687
Featured
|
RH01687 is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. |
|
| DC23734 |
Rheb inhibitor NR1
Featured
|
Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK. |
|
| DCAPI1188 |
Rhein(Monorhein) |
Rhein(Monorhein) |
|
| DCAPI1221 |
Rheochrysidin (Physcione) |
Rheochrysidin (Physcione) |
|
| DC23186 |
Rhosin |
Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG. |
|
| DC23192 |
Rhosin hydrochloride
Featured
|
Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG. |
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