DC33446 |
Aethisteron |
Ethisterone is a synthetic contraceptive and progesterone receptor agonist previously used in contraceptics. Derivatives inhibit prostate cancer cell growth. |
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DC33447 |
Amea 100 |
Ethoxyquin is an HSP90 inhibitor and antioxidant used as a pesticide and preservative in animal feed. |
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DC33448 |
HSDB 445 |
Farnesol is found in various essential oils. It regulates the volatility of odorants in perfumes. It displays a variety of biological activities, including cell cycle arrest and stimulating p21 and p27 expression in pancreatic adenocarcinoma cells, increasing latency to tumor formation in TPA-induced skin carcinogenesis, and inhibiting growth of Aspergilius and Candida. |
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DC33450 |
Flavanone |
Flavanone is found in various plant sources. It inhibits proliferation of tumor cells and may decrease oxidative damagae, inhibit angiogenesis, and suppress growth of bacteria. |
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DC33451 |
Flutriafol |
Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist that prevents sterol synthesis and disrupts membrane function. It also induces striatal dopamine release and decreases oxidative damage. |
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DC33452 |
Forchlorfenuron |
Forchlorfenuron is a synthetic cytokinin, plant growth regulator, and filament polymerization inducer. It induces paralysis in Schistosoma and inhibits proliferation and migration of prostate cancer cells. |
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DC33453 |
Calcium fosfomycin |
Fosfomycin calcium is a MurA and isopentenyl mevalonate kinase inhibitor that prevents synthesis of bacterial cell walls. It also prevents aminoglycoside antibiotic-induced nephrotoxicity and lowers serum levels of TNF-α, IL-1β, and IL-6 in models of septic Pseudomonas infection. |
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DC33454 |
HSDB 3486 |
Fusarenon-X is a mycotoxin found in Fusarium. It induces DNA strand breakage and decreases food intake. |
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DC33455 |
Fumonisin B2 |
Fumonisin B2 is a mycotoxin and grain contaminant. It inhibits sphingosine acyltransferase and disrupts sphingolipid metabolism. |
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DC33456 |
D-Galactosamine HCl |
D-Galactosamine HCl is a galactose-derived hexosaine sugar and component of FSH and LH. It is used to induce endotoxic shock. |
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DC33457 |
Tetraprenol |
Geranylgeraniol is an geranylgeranyl pyrophosphate analog used in synthesis of vitamins E and K. It induces apoptosis and inhibits growth of various tumor cells, suppresses growth of Mycobacterium, and protects monocytes against statin-induced cytotoxicity. |
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DC33458 |
Ginkgoic acid |
Ginkgolic acid is an HIV protease and fatty acid synthase inhibitor found in Ginkgo. It suppresses HIV infection, inhibits growth of Staphyloccus, Escherichia, and Bacillus, increases activity of PP2C in neurons, and induces apoptosis in cancer cells. |
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DC33459 |
Aspergillin |
Gliotoxin is a toxin found in Aspergillus. It induces apoptosis in cervical cancer cells and chondrosarcoma cells, suppresses the adaptive immune response in leukocytes, and inhibits the proteasome in Plasmodium falciparum. |
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DC33462 |
1-Monolaurin |
Monolaurin, also known as Glyceryl monolaurate, is a surfactant and emulsifer found in coconut oil. It inhibitis growth of Staphylococcus, Streptococcus, Gardnerella, Candida, and Haemophilus, and decreases production of pro-inflammatory cytokines. |
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DC33463 |
Glycidamide |
Glycidamide is a carcinogen and metabolite of acrylamide that induces DNA adduct formation and mutations. |
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DC33464 |
GSK 2830371
Featured
|
GSK 2830371 is a selective inhibitor of the WiP1 phosphatase that demonstrates potent antitumor activity in both lymphoma and neuroblastoma preclinical models by suppressing malignant cell proliferation. |
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DC33465 |
Guggulsterone |
Guggulsterone is a FXR antagonist found in myrrh. It displays a wide variety of biological activities, including disrupting cytoskeletal organization, inhibiting doxorubicin-induced toxicity in cardiomyoc |
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DC33466 |
H7 dihydrochloride |
H7 is a specific protein kinase C inhibitor and protein kinase G inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol. |
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DC33467 |
H8 |
H8 dihydrochloride is a PKA inhibitor that modulates Ca 2+ signaling. |
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DC33468 |
Antibiotic Tan 420F |
Herbimycin is an inhibitor of HSP90, PKC, Src and Bcr-Abl. It inhibits proliferation of chronic myelogenous leukemia cells. |
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DC33469 |
Anvil L |
Hexaconazole is a pesticide and demethylation inhibitor that prevents sterol synthesis and disrupts membrane function. It also induces production of apigenin-7-glucoside and other antioxidative compounds and inhibits growth of nitrogen-fixing bacteria. |
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DC33470 |
Hexamethionium bromide |
Hexamethonium bromide non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant. |
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DC33471 |
Cycloestrol |
Hexestrol is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation. |
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DC33472 |
NSC 131114 |
Hexylglutathione is a glutathione-S-transferase inhibitor used to study the effects of phase II enzymes and glutathione. |
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DC33473 |
(±)-Dihydro-3-amino-2(3H)-thiophenone hydrochloride |
DL-Homocysteinethiolactone HCl is a cysteine derivative that binds to and induces conformational changes in various plasma proteins, slowing coagulation and inducing oxidative stress. It decreases left ventricular systolic blood pressure and cardiac force and induces seizures in vivo. |
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DC33474 |
Arthrease |
Hyaluronate Sodium is endogenous anionic non-sulfated glycosaminoglycan found in conective tissue and synovial fluid. It binds cell surface proteins and causes inflammation. |
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DC33475 |
(E)-4-Hydroxytamoxifen |
Afimoxifene, E-isomer, also called (E)-4-Hydroxytamoxifen, is a SERM and active metabolite of tamoxifen. The E isomer is less active thatn the Z isomer. It induces autophagy, vacuole formation and KRAS degradation in cancerl cells and decreases contractility in myocytes. |
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DC33476 |
Antihelmycin |
Hygromycin B is a protein translocation inhibitor that suppresses protein and RNA synthesis of bacteria. and viruses by inducing misreadings during translation. |
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DC33477 |
2-Hydroxyestradiol |
2-Hydroxyestradiol is an estradiol metabolite with low affinity for ERs. It decreases release of prostagladin E2, suppresses H202-induced oxidative damage, and inhibits HIF-1α signaling. |
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DC33478 |
2-Heptylfuran |
2-Heptylfuran is an antioxidant found in cooked meat. It induces phase II enzyme activity and inhibits benzol[a]pyrene-induced tumor development. |
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