DC33626 |
CPFX1302 |
CPFX1302 is a biochemical |
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DC33627 |
SEP-0371845 |
SEP-0371845 is a biochemical |
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DC33628 |
TP-4748 |
TP-4748 is a biochemical. |
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DC33629 |
TP748 |
TP748 is a bioactive chemical. |
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DC33630 |
ZN2007-RM1 |
ZN2007-RM1 is a bioactive chemical. |
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DC33632 |
CAY10594
Featured
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CAY10594 is a potent phospholipase D2 inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. |
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DC33637 |
RU-SKI43 HCl |
RU-SKI 43 is an inhibitor of Hat. It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. RU-SKI-43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR. |
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DC33638 |
CY5.5-COOH |
CY5.5 carboxylic acid, also known as Cyanine5.5 carboxylic acid, is a Far-red emitting fluorescent dye with Ex/Em wavelength 673nm/707nm. CY5.5 carboxylic acid can be considered non-reactive for most applications and used as a control or reference sample, and for instrument calibration. |
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DC33641 |
PSB-12054 |
PSB-12054 is a potent P2X4 receptor inhibitor. PSB-12054 has IC(50) of 0.189 μM and good selectivity versus the other human P2X receptor subtypes. |
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DC33643 |
ARC39 |
ARC39 is acid sphingomyelinase inhibitor (IC50 =20 nM). |
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DC33644 |
MC2050 HCl |
MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells. |
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DC33645 |
TBK1/IKKε-IN-5
Featured
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QUN97653, also known as TBK1/IKKε-IN-5, is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively. QUN97653 was first reported in patent WO 2016049211. It has CAS#1893397-65-3 without code name. For the convenience of scientific communication, we temporally name it as QUN97653, which was based on Hodoodo Chemical Nomenclature (https://hodoodo.com/hodoodo-chemical-nomenclature). |
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DC33647 |
CM-4620
Featured
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CM-4620 is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM, 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively. |
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DC33648 |
Hexakis(p-bromophenoxy)cyclotriphosphazene
Featured
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LUN76721 has CAS#4376-72-1, is a cyclophosphazene and a useful chemical reagent. Cyclophosphazenes have been studied among others as flame retardant additives, high temperature fluids, clathrates, photostabilizers, or antioxidants in organic polymers. Cyclophosphazenes have also been used as phase transfer catalysts, as polypodants and cryptands. Cyclophosphazenes have also been successfully used as biologically active agents. Moreover cyclotriphosphazenes, were used for polymer functionalization and synthesis, as pendant groups or monomers for polyphosphazene synthesis, especially those bearing six chlorine atoms or phenoxy groups. |
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DC33649 |
Boc-Val-Cit-PAB
Featured
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Boc-Val-Cit-PAB is a linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. The Boc group can be deprotected under acidic conditions to generate a free amine group. |
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DC33650 |
IUN76750
Featured
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UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. It lowers elevated levels of AST, ALT, creatinine, BUN, and TNF-α, increases the reduced platelet count in mice, and acts as a novel chemo- and radioprotective agent. |
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DC33651 |
ML188
Featured
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ML188 is a Potent Noncovalent Small Molecule Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease. The X-ray structure of SARS-CoV 3CLpro bound with ML188 was instrumental in guiding subsequent rounds of chemistry optimiz |
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DC33652 |
LY-3381916
Featured
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LY-3381916, also known as IDO1-IN-5, is a potent, selective and brain penetrated DO1 inhibitor. LY3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, LY3381916 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs). |
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DC33653 |
ML417
Featured
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ML417 is a Highly Selective D3 Dopamine Receptor Agonist. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. Screening of ML417 against multiple G protein-coupled receptors revealed exceptional global selectivity. Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity. ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs. |
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DC33654 |
Fentin |
Fentin is an organotin compound (OTC) widely used as an agricultural fungicide and miticide. |
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DC33655 |
Methyldymron |
Methyldymron is a bioactive chemical. |
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DC33656 |
Noreximide |
Noreximide is a sedative. |
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DC33657 |
DNOC |
DNOC is an agricultural chemical. |
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DC33658 |
EINECS 206-113-3 |
Robinin is a flavone glycoside based on kaempferol. |
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DC33659 |
Arsicodile |
Sodium cacodylate is an arsenical that has been used as a dermatologic agent and as an herbicide. |
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DC33660 |
2-Naphthalenecarboxamide |
C.I. 37530 is a color developer. |
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DC33661 |
2-Naphthanilide |
3-Hydroxy-3'-nitro-2-naphthanilide is a bioactive chemical. |
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DC33662 |
3-Cyclohexene-1-methanol |
Levomenol is found in fats and oils. |
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DC33663 |
Antibiotic BB-K 8 |
Amikacin is an aminoglycoside antibiotic derived from kanamycin A. Like other aminoglycosides, amikacin binds to bacterial ribosomes and disrupts translation.1 However, the specific binding sites differ between different aminoglycoside antibiotics, as do the mechanisms of resistance. Amikacin is effective against Gram-negative and Gram-positive bacteria. |
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DC33664 |
Bekanamycin sulfate |
Bekanamycin sulfate is a bioactive chemical. |
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