| DC33996 |
Long trebler phosphoramidite |
Long trebler phosphoramidite is a branching reagent for oligonucleotide synthesis allowing to synthesize branched DNA structures using a standard DNA synthesizer.Trebler amidite can be used to attach several modifier amidites to the 5'-end of an oligonucleotide - for example, three biotin residues can be attached at once. |
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| DC33997 |
Pyrene phosphoramidite dU |
Pyrene is polycyclic aromatic hydrocarbon which is well-known for its ability to intercalate into DNA. Pyrene features intense blue fluorescence. Its parameters depend strongly on fluorophore microenvironment. Therefore, fluorescence spectra of pyrene are used for the extraction of structural information about site surrounding pyrene. Two pyrenes in close proximity usually form excimers easily detectable by excimer fluorescence. Pyrene can also be a FRET donor to other fluorophores such as perylene. |
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| DC33998 |
N-trifluoroacetyl (TFA) |
N-trifluoroacetyl (TFA) protected aminolink C6 phosphoramidite for the synthesis of 5'-amino-modified oligonucleotides. TFA protection is smoothly removed during ammonia deprotection, and does not require any additional steps. If necessary, the resulting oligonucleotides can be purified by ion exchange chromatography, or gel electrophoresis. |
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| DC33999 |
Azide-PEG3-Azide |
PEG3 (triethylene glycol) diazide (1,8-diazido-3,6-dioxaoctane) is a symmetrical bifunctional crosslinker bearing two azide groups. |
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| DC34000 |
PEG4 diazide |
PEG4 diazide is a hydrophilic linker with two azide groups. Both can be modified by Click chemistry, either by a copper catalyzed reaction with terminal alkynes, or by a copper-free reaction with cycloalkynes. Azides can also participate in the Staudinger ligation reaction. |
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| DC34001 |
orelabrutinib
Featured
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Bruton tyrosine kinase inhibitor |
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| DC34002 |
Iodo-PEG3-Iodide |
PEG3 diiodide is a homobifunctional linker with two iodide functional groups which are very reactive against many nucleophiles like thiols, amines, alkoxy anions, etc. Can be used to synthesize hydrophilic symmetrical conjugates. |
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| DC34003 |
PEG3 dicarboxylic acid |
PEG3 dicarboxylic acid is a homobifunctional linker with two carboxylic acid groups flanking the PEG3 molecule.
The linker is highly hydrophilic and useful for the conjugation and immobilization of proteins, peptides, and other biomolecules. The carboxy groups can be activated by carbodiimides |
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| DC34004 |
Sulfo-Cyanine5 bis-NHS ester |
Sulfo-Cyanine5 bis-NHS ester is a water soluble bifunctional dye possessing two NHS ester functions. It is an analog of Cy5? bis-NHS ester.
The dye is useful for the cross-conjugation of amines, and for other advanced labeling applications. |
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| DC34005 |
Sulfo-Cyanine7.5 dicarboxylic acid |
Sulfo-Cyanine7.5 dicarboxylic acid is a bifunctional near infrared fluorescent dye with two carboxylic acid groups.
The reagent is useful as a cross-linker that is NIR emitting. The carboxylic acid groups can be activated by carbodiimide chemistry. |
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| DC34006 |
BDP 558/568 NHS ester |
BDP 558/568 is a borondipyrromethene fluorophore with emission in the yellow part of the spectrum. Its absorption and emission spectra are in similar range as TAMRA, BDP TMR, Cyanine3, and sulfo-Cyanine3. This is an amine reactive NHS ester. |
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| DC34007 |
BDP 581/591 NHS ester |
BDP 581/591 is a borondipyrromethene dye that has relatively long fluorescence lifetime and two photon excitation cross section. It is useful for fluorescence polarization assays. Due to the presence of a diene system, it can react with reactive oxygen species (ROS) with a change of fluorescence.
This is the NHS ester derivative for the conjugation with primary and secondary amine groups of proteins, peptides, and other molecules. |
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| DC34008 |
BDP 630/650 X NHS ester |
BDP 630/650 is a borondipyrromethene fluorophore that has a high molar extinction coefficient, excellent quantum yield, and a relatively long lifetime of the excited state. Due to it, this fluorophore is useful for fluorescence polarization assays that allow to detect binding between molecules.
This is an amine reactive NHS ester. It contains an aminohexanoyl linker between the fluorophore and the reactive group. |
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| DC34009 |
BDP 650/665 X NHS ester |
BDP 650/665 is a borondipyrromethene dye with far red excitation and emission. The dye has a good molar extinction coefficient and emission quantum yield.
The NHS ester can be conjugated with amine groups of proteins, peptides, and other molecules. The molecule contains an additional aminohexanoic acid linker. |
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| DC34010 |
Cyanine3.5 NHS ester |
Cyanine3.5 NHS ester is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.
Cyanine3.5 NHS ester can replace NHS esters of Cy3.5, Alexa Fluor 594, DyLight 594. |
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| DC34011 |
VPC-13566 |
VPC-13566 is an advanced BF3-specific small molecule that was previously reported to effectively inhibit AR transcriptional activity and to displace the BAG1L peptide from the BF3 pocket. VPC-13566 inhibits the growth of various prostate cancer cell lines, including an enzalutamide-resistant cell line, and reduces the growth of AR-dependent prostate cancer xenograft tumors in mice. |
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| DC34012 |
Sulforaphene |
Sulforaphene efficiently decreased the viability of breast cancer cells, while normal cells (MCF10A) were less sensitive to the analyzed isothiocyanate. Sulforaphene induced G2/M cell cycle arrest, as well as disturbed cytoskeletal organization and reduced clonogenic potential of the cancer cells. Sulforaphene induced apoptosis in a concentration-dependent manner which was associated with the oxidative stress, mitochondria dysfunction, increased Bax:Bcl2 ratio and ADRP levels. |
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| DC34013 |
Benzoctamine Hydrochloride |
Benzoctamine is a drug that possesses sedative and anxiolytic properties. Medically, benzoctamine is used as a treatment for anxious outpatients to control aggression, enuresis, fear, and minor social maladjustment in children. |
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| DC34014 |
5-(N,N)-Dimethylamiloride Hydrochloride |
5-(N,N)-Dimethylamiloride Hydrochloride is a Na(+)-H+ exchange inhibitor. |
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| DC34015 |
Cbz-B3A |
Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks 68% of translation. Cbz-B3A binds to ubiquilins 1, 2, and 4. |
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| DC34016 |
ASMI |
ASMI is a cell-permeable cysteine selective, sensitive, and ratiometric fluorescent turn-on probe. |
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| DC34017 |
MS-1020 |
MS-1020 is a JAK3 and STAT3 inhibitor. MS-1020 potently inhibits persistently-active STAT3 in a cell type-specific manner. MS-1020 selectively blocks constitutively-active JAK3 and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling. |
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| DC34018 |
(S)-Crizotinib |
(S)-Crizotinib is an MTH1 inhibitor. By inhibiting MTH1, (S)-Crizotinib disrupts nucleotide pool homeostasis, induces an increase in DNA single-strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumor growth in animal models. |
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| DC34019 |
MEDICA 16 |
MEDICA16 is a GPR40 agonist. MEDICA 16 is a β,β'-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. |
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| DC34020 |
(Z)-Guggulsterone |
(Z)-Guggulsterone is a phytosteroid found in the resin of the guggul plant, Commiphora mukul. It acts as an antagonist of the farnesoid X receptor in humans. |
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| DC34021 |
Atrazine |
Atrazine is an herbicide of the triazine class. Atrazine functions by binding to the plastoquinone-binding protein in photosystem II, which animals lack. Plant death results from starvation and oxidative damage caused by breakdown in the electron transport process. |
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| DC34023 |
ISAM-140 |
ISAM-140 is a potent and highly selective A2B adenosine receptor antagonist. |
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| DC34024 |
Benzetimide HCl |
Benzetimide HCl, also known as EINECS 227-072-8, Spasmentral, and Dioxatrine, is a muscarinic acetylcholine receptor antagonist. Benzetimide HCl has been used to treat neuroleptic-induced parkinsonism. Benzetimide is an enantiomer of dexetimide. |
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| DC34025 |
AkaLumine
Featured
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AkaLumine is a luciferin analogue. The bioluminescence produced by AkaLumine in reactions with native firefly luciferase is in the near-infrared wavelength ranges (λmax=677?nm), and yields significantly increased target-detection sensitivity from deep tissues with maximal signals attained at very low concentrations, as compared with D-luciferin and emerging synthetic luciferin CycLuc1. |
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| DC34026 |
Isomaltitol |
Isomaltitol, also known as Palatinit or Isomalt, is a sugar alcohol. Isomaltitol is commonly used as a sweetener in food products. There is some evidence that Isomaltitol could be used to aid mucus clearance in cystic fibrosis patients. |
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