| DC34058 |
15-Hexadecynoic acid |
15-Hexadecynoic acid, also known as Alkynyl Palmitic Acid, is a chemical probe for SCRIB palmitoylation and palmitoyl acyltransferases (PATs). This biochemical can be used to identify and characterize the post-translational S-palmitoylation of proteins with Click Chemistry. |
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| DC34059 |
SPL-334 |
SPL-334 is an inhibitor of S-nitrosoglutathione reductase. SPL-334 prevents weight loss, attenuating lung inflammation and fibrosis in a bleomycin injury model of interstitial lung disease in mice. |
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| DC34060 |
R,R-THC |
R,R-THC is a estrogen receptor-β selective antagonist. R,R-THC also inhibits DHEA and DHEA metabolite transcriptional activity in ERβ-transfected cells. R,R-THC has also been shown to have neuroprotective effects against glutamate-induced death in primary rat cortical cells and mouse N29/4 hypothalamic cells. |
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| DC34062 |
Fe-TMPyP |
Fe-TMPyP is a peroxynitrite decomposition catalyst. Fe-TMPyP also binds to the prion protein PrP and inhibits misfolding. |
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| DC34063 |
Trolox |
Trolox is an antioxidant like vitamin E and it is used to reduce oxidative stress or damage. Trolox is also used as a benchmark to assess the potency of other antioxidants. Trolox equivalent antioxidant capacity (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE). |
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| DC34064 |
Picloram |
Picloram is a systemic herbicide used for general woody plant control. It also controls a wide range of broad-leaved weeds, but most grasses are resistant. |
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| DC34065 |
Lidoflazine |
Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. |
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| DC34066 |
Propidium Iodide
Featured
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Propidium Iodide is a fluorescent intercalating agent that can be used to stain cells. Propidium Iodide is used as a DNA stain in flow cytometry to evaluate cell viability or DNA content in cell cycle analysis, and in microscopy to visualise the nucleus and other DNA-containing organelles. Propidium Iodide cannot cross the membrane of live cells, making it useful to differentiate necrotic, apoptotic and healthy cells. |
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| DC34067 |
PF-6422899 |
PF-6422899 is an irreversible inhibitor of EGFR kinase activity. PF-6422899 binds covalently to active-site cysteine residues in the ATP binding pocket of EGFR. |
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| DC34068 |
NPD9948 |
NPD9948 is a competitive MTH1 inhibitor. |
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| DC34069 |
JX-401 |
JX-401 is a p38alpha inhibitor containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. |
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| DC34070 |
5-Methylurapidil |
5-Methylurapidil is an alpha1A-adrenoceptor antagonist. It has also been used for competitive binding in radioligand binding assays. |
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| DC34071 |
Pentetrazol |
Pentetrazol, also known as pentylenetetrazole, metrazol, pentetrazol (INN), pentamethylenetetrazol, Corazol, Cardiazol or PTZ, is a non-competitive GABA antagonist. It was formerly used as a drug for circulatory and respiratory stimulation. |
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| DC34072 |
NBD-Pen |
NBD-Pen high-sensitivity, specific fluorescence probe for lipid radicals. NBD-Pen directly detected lipid radicals in living cells by turn-on fluorescence. In a rat model of hepatic carcinoma induced by diethylnitrosamine (DEN), NBD-Pen detected lipid radical generation within 1 hour of DEN administration. |
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| DC34073 |
PACA |
PACA, also known as N-Propargyl Caffeamide, potentiates NGF-induced neurite outgrowth and attenuates 6-hydroxydopamine neurotoxicity in neuronal culture. Insufficient production of nerve growth factor (NGF) is implicated in Parkinson's disease (PD). |
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| DC34074 |
LSF |
Lisofylline, also known as LSF, improves cellular mitochondrial function and blocks interleukin-12 (IL-12) signaling and STAT-4 activation in target cells and tissues. IL-12 and STAT-4 activation are important pathways linked to inflammation and autoimmune damage to insulin producing cells. Therefore, LSF and related analogs could provide a new therapeutic approach to prevent or reverse type 1 diabetes. |
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| DC34075 |
EF24
Featured
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EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK.
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| DC34077 |
Fasnall |
Fasnall is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall also shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) breast cancer, particularly when combined with carboplatin. |
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| DC34078 |
Ani9 |
Ani9 is a potent ANO1 inhibitor. Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth muscle contraction, nociception and cancer progression. Ani9 may be a useful pharmacological tool for studying ANO1 and a potential development candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma. |
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| DC34079 |
PCB118 |
PCB118 is a polychlorinated biphenyl, and an environmental contaminant. PCB118 induces inflammatory responses in the thyroid through a JNK and aryl hydrocarbon receptor-mediated pathway. |
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| DC34080 |
MTOB |
MTOB is the substrate for the C-terminal Binding Protein (CtBP). MTOB can interfere with CtBP oncogenic activity in cell culture and in mice. It also positively regulates TCF-4 signaling, leading to cancer stem cells (CSC) growth and self-renewal. |
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| DC34082 |
MDK-4025 |
MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons. The last four digits of the compound's CAS registry number are used in its name. |
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| DC34083 |
L-XMP Sodium |
L-XMP Sodium is a guanosine monophosphate synthetase inhibitor. |
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| DC34084 |
cPTIO |
Carboxy-PTIO is a NO scavenger. Streptozotocin (STZ) induced diabetes (type I) in rats is preventable using a simultaneous equimolar injection of carboxy-PTIO. |
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| DC34085 |
Epiblastin A
Featured
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Epiblastin A is a Casein Kinase 1 (CK1) inhibitor. Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). |
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| DC34086 |
2-Arachidonoylglycerol |
2-Arachidonoylglycerol is an endocannabinoid, an endogenous agonist of the CB1 receptor. At a concentration of 0.3nM, 2-Arachidonoylglycerol induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. |
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| DC34087 |
Plastochromanol |
gamma-Tocotrienol is one of the four types of tocotrienol, a type of vitamin E. gamma-Tocotrienol is a radioprotector, antioxidant, and shows antitumor and antihypertensive effects in vivo. |
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| DC34088 |
CCPA |
CCPA, also known as 2-Chloro-N6-cyclopentyladenosine, is a centrally active, potent, and selective adenosine A1 receptor (ADORA1) agonist. In the lungs of mice and humans four adenosine receptors are expressed with different roles, having pro- and anti-inflammatory roles, determining bronchoconstriction and regulating lung inflammation and airway remodeling. |
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| DC34089 |
YM511 |
YM511 is a non-steroidal selective aromatase inhibitor. YM511 may be useful in the treatment of estrogen-dependent cancers without affecting serum levels of other steroid hormones. |
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| DC34090 |
BIX |
BIX is a BiP (Hsp70-5) ER chaperone inducer. BIX induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. |
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