| DC34371 |
ACPT-1 |
ACPT-1 is an agonist of group III mGlu receptors. |
|
| DC34372 |
AMPK activator D942 |
AMPK activator D942 is a cell-permeable activator of AMPK. |
|
| DC34373 |
N2-OH-PhIP
Featured
|
N2-OH-PhIP is a PhIP metabolite. |
|
| DC34374 |
N12N |
N12N is a polyamine inverse agonist of NMDA receptor. |
|
| DC34375 |
PMX464 |
PMX464 is a cytocidal anti-trypanosomal inhibitor that acts by targeting trypanothione metabolism. It is also a putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. |
|
| DC34377 |
Qc1 |
Qc1 is a reversible, non-competitive inhibitor of threonine dehydrogenase (TDH). |
|
| DC34378 |
Norchlorcyclizine |
Norchlorcyclizine is a partially selective NPR-B inhibitor. It also acts as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1). |
|
| DC34379 |
3AC
Featured
|
3AC is an inhibitor of SH2 domain-containing inositol-5’-phosphatase 1 (SHP-1). It is selective for SHP-1 over SHP-2 and phosphatase and tensin homolog (PTEN). 3α-Aminocholestane induces hyperactivation of the tyrosine kinase SYK in patient-derived Ph+ acute lymphoblastic leukemia (ALL) cells and selectively induces cytotoxicity in these cells over mature B cell lymphoma cells. It reduces leukemia burden and increases survival in a tyrosine kinase inhibitor-resistant patient-derived Ph+ ALL mouse xenograft model when administered at a dose of 50 mg/kg. 3α-Aminocholestane reduces cell viability of OPM2 multiple myeloma (MM) cells in a concentration-dependent manner and of RPMI8226 MM cells when used at concentrations greater than or equal to 12.5 μM. It halts the cell cycle at the G0/G1 or G2/M stages in the highly proliferative OPM2 or less proliferative RPMI8226 cell lines, respectively. It induces apoptosis via activation of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP) in OPM2 cells but not in RPMI8226 cells. 3α-Aminocholestane reduces tumor burden and increases survival in an OPM2 mouse xenograft model. |
|
| DC34380 |
SMI481 |
SMI481 is the first small-molecule inhibitor of Sec14-like phosphatidylinositol transfer proteins (PITPs). |
|
| DC34381 |
Phox-I2 |
Phox-I2 is a second generation inhibitor of the p67phox interaction with Rac1, effective in suppressing reactive oxygen species production by human and murine neutrophils. |
|
| DC34382 |
YN1 |
YN1 is a PFKFB3 inhibitor. |
|
| DC34383 |
IDO1-IN-1 |
IDO1-IN-1 is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1). |
|
| DC34384 |
NQTrp
Featured
|
NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin. |
|
| DC34385 |
DTNB |
DTNB is an allosteric inhibitor of the NS2B-NS3 protease from dengue virus. It acts as a reagent for the determination of reactive sulfhydryl groups. |
|
| DC34386 |
RTC13 |
RTC13 is a premature termination codon (PTC) readthrough inducer that acts by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy. |
|
| DC34387 |
Paroxetine maleate |
Paroxetine maleate is a selective serotonin reuptake inhibitor and an antidepressant. |
|
| DC34388 |
ML336
Featured
|
ML336 is an inhibitor of of the Venezuelan equine encephalitis virus (VEEV) strain TC-83. |
|
| DC34389 |
MAL2-11B |
MAL2-11B is an inhibitor of Simian Virus 40 replication. It acts by targeting the molecular chaperone function and ATPase activity of T antigen. MAL2-11B is also a MAL3-101 precursor. |
|
| DC34390 |
CCCI-01
Featured
|
CCCI-01 is an inhibitor of centrosome clustering in cancer cells. |
|
| DC34391 |
C527 |
C527 is a inhibitor of USP1 target ID1 degradation in leukemic cells. |
|
| DC34392 |
JCP174
Featured
|
JCP174 is an inhibitor of a depalmitoylase that enhances Toxoplasma host-cell invasion by targeting TgPPT1. |
|
| DC34393 |
BVT.13 |
BVT.13 is a selective PPAR-gamma activator. |
|
| DC34394 |
R(+)-SKF-38393A |
R(+)-SKF-38393A is a D1 dopamine receptor agonist. It is also a more active enantiomer of (±)-SKF-38393A. |
|
| DC34395 |
Amiloride HCl anhydrous |
Amiloride HCl anhydrous is a Na+ channel blocker. It acts by blocking TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. |
|
| DC34396 |
(R)-Pantetheine |
(R)-Pantetheine is a metabolite in carbapenem biosynthesis, pantothenate and CoA biosynthesis and biosynthesis of secondary metabolites. |
|
| DC34397 |
(-)-Quinpirole hydrochloride |
(-)-Quinpirole HCl is the most widely used D2 agonist in in vivo and in vitro studies. |
|
| DC34398 |
Ro 41-0960 |
Ro 41-0960 is a reversible and orally-active COMT-inhibitor. |
|
| DC34399 |
R(+)-6-Bromo-APB hydrobromide |
R(+)-6-Bromo-APB HBr is a potent D1 Dopamine receptor agonist. |
|
| DC34400 |
NeuroSensor 521 |
NeuroSensor 521 is a fluorescent turn-on sensor. It acts by binding catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate and does not interact with secondary amines such as epinephrine. |
|
| DC34401 |
NTE-122 |
NTE-122 is a potent, selective and competitive inhibitor of Acyl-CoA:cholesterol acyltransferase (ACAT). |
|
