| DC34422 |
Pyr3 |
Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). |
|
| DC34423 |
AC-93253 iodide |
AC-93253 iodide is a SIRT2 selective inhibitor. It acts by significantly enhancing acetylation of tubulin, p53, and histone H4. |
|
| DC34425 |
S3QEL-2 |
S3QEL-2 is a modulator of the retrograde signaling. It acts by strongly mitigating the oxidative stress-induced apoptosis that limits the yield of functional ?-cells from intact islets. |
|
| DC34426 |
2002-H20 |
2002-H20 is an inhibitior of Aβ42-induced cytotoxicity. It acts by binding the Alzheimer's Aβ peptide and reducing its cytotoxicity. |
|
| DC34427 |
EIPA |
EIPA is a selective blocker of Na+/H+ antiport. |
|
| DC34428 |
A1899 |
A1899 is a potent and selective TASK-1 and TASK-3 antagonist. |
|
| DC34429 |
L-NMMA acetate |
L-NMMA acetate is an endothelium-derived relaxing factor inhibitor. It acts by inhibiting the generation of NO from arginine. |
|
| DC34432 |
Brilliant Blue G |
Brilliant Blue G is a P2X7 purinergic receptor antagonist. |
|
| DC34434 |
AZD7762 Hydrochloride |
AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and potentiating DNA-targeted therapies. |
|
| DC34435 |
Dicyclanil |
Dicyclanil is an insect growth regulator. |
|
| DC34436 |
XRP44X |
XRP44X is a potent Ras-Net (Elk-3) pathway inhibitor. |
|
| DC34437 |
Tyrphostin AG957 |
Tyrphostin AG957 is a tyrosine kinase inhibitor, selectively inhibiting human p210 tyrosine kinase activity. |
|
| DC34438 |
Blebbistatin |
(±)-Blebbistatin is a cell cycle inhibitor and a selective inhibitor of non-muscle myosin II. |
|
| DC34439 |
5-CFDA |
5-CFDA is a cell membranes permeatable non-fluorescent prodrug of 5-carboxyfluorescein. It shows strongly fluorescent to differentiate viable cells from apoptotic cells after being enzymatically hydrolyzed inside cells. |
|
| DC34440 |
6-CFDA |
6-CFDA is a cell membranes permeatable non-fluorescent prodrug of 5-carboxyfluorescein. It shows strongly fluorescent to differentiate viable cells from apoptotic cells after being enzymatically hydrolyzed inside cells. |
|
| DC34441 |
Epigenetic Multiple Ligand |
Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation. |
|
| DC34442 |
BAY32-5915 |
BAY32-5915 is an IKKalpha inhibitor. |
|
| DC34443 |
Cilostamide |
Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). |
|
| DC34444 |
Clofilium Tosylate |
Clofilium Tosylate is a K+ channel blocker, cardiac depressant, and anti-arrhythmic agent. |
|
| DC34445 |
Ranitidine-N-oxide |
Ranitidine-N-oxide is a metabolite of Ranitidine. Ranitidine is a histamine H2-receptor antagonist, inhibiting the normal and meal-stimulated secretion of stomach acid. Ranitidine, sold under the trade name Zantac among others, is a medication which decreases stomach acid production. |
|
| DC34446 |
Iprovalicarb |
Iprovalicarb is a fungicide specific to oomycetes. |
|
| DC34447 |
NVS-CECR2-1 |
NVS-CECR2-1 is a potent and selective CECR2 inhibitor. |
|
| DC34448 |
UK-78282 Hydrochloride |
UK-78282 HCl is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels. |
|
| DC34449 |
Dofequidar fumarate |
Dofequidar fumarate is a potent inhibitor of MDR-1. |
|
| DC34450 |
Fendiline Hydrochloride |
Fendiline HCl is a potent acid sphingomyelinase (ASM) inhibitor, reducing the phosphatidylserine (PtdSer) and cholesterol content of the inner plasma membrane and inhibiting calcium function in muscle cells in excitation-contraction coupling. |
|
| DC34451 |
HDAC8-IN-2 |
HDAC8-IN-2 is a selective HDAC8 inhibitor. |
|
| DC34452 |
Aloenin |
Aloenin is a moderate inhibitor of BACE. |
|
| DC34453 |
PF-06424439
Featured
|
PF-06424439 is a potent and selective Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1. PF-06424439 demonstrated excellent ADMET properties and decreased circulating and hepatic lipids when orally administered to dyslipidemic rodent models. PF-06424439 inhibited DGAT2 of different species (human, rat, and dog) with similar potency. Among related acyltransferases, no significant inhibition was observed for PF-06424439 (up to 50 μM) against human MGAT2 or MGAT3, DGAT1, or mouse MGAT1, indicating a high selectivity (>2000-fold) against these enzymes. |
|
| DC34455 |
TP2 |
TP2 is an inhibitor of polyketide synthase 13 (Pks13), preventing synthesis of mycolic acid and resulting in mycobacterial cell death. |
|
| DC34456 |
Neurodazine |
Neurodazine is a neurogenic inducer for converting pluripotent P19 cells into electrophysiologically active neurons. |
|
