| DC34644 |
Chlorphenoxamine Hydrochloride |
Chlorphenoxamine HCl is an antihistaminic agent which reverses multidrug resistance in L1210 tumor cells. |
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| DC34645 |
Toresten |
Thiethylperazine Maleate is a dopamine antagonist which blocks postsynaptic dopamine 2 (D2) receptors. |
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| DC34646 |
Aminophylline |
Aminophylline is an inhibitor of cAMP or cGMP phosphodiesterases, increasing levels of the second messenger cAMP or cGMP intracellularly, also acting as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart. |
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| DC34647 |
Mirodenafil Dihydrochloride |
Mirodenafil belongs to the drug class PDE5 inhibitors, which includes avanafil, sildenafil, tadalafil, udenafil, and vardenafil, and is the first-line treatment for erectile dysfunction. |
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| DC34649 |
NCGC00029283
Featured
|
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively. |
|
| DC34650 |
NCGC00063279 |
NCGC00063279 is a novel inhibitor of the werner syndrome helicase-nuclease (wrn) helicase |
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| DC34651 |
EC23
Featured
|
EC23 is a fluorescent, voltage, indicator, action, potentials, mammalian, neurons, perturbations, cardiac, waveform, pluripotent, stem, cell-derived, cardiomyocytes |
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| DC34652 |
HPA-12 |
HPA-12 is a novel potent inhibitor of cert, binding to the ceramide-binding pocket in the cert start domain |
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| DC34653 |
Ametryn |
Ametryn is a methylthiotriazine based herbicide which inhibits photosynthesis and other enzymatic processes. Ametryn is used to control broadleaf weeds and annual grasses in pineapple, sugarcane and bananas. |
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| DC34654 |
Mephenesin |
Mephenesin is a centrally acting muscle relaxant with a short duration of action. It can be used as an antidote in strychnine poisoning. |
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| DC34655 |
Triethoxycaprylylsilane |
Triethoxycaprylylsilane is an organically modified silane that has been found to aggregate in the form of normal micelles as well as reverse micelles. The molecule can be hydrolyzed to form a hydrated silica network while the n-octyl groups are held together through hydrophobic interaction. The network can host hydrophobic molecules through interactions with the hydrophobic core and the hydrophilic silica cores can encapsulate hydrophilic molecules such as horseradish peroxidase (HRP). Triethoxycaprylylsilane is commonly used in plastics applications. |
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| DC34656 |
Flucycloxuron |
Flucycloxuron is a chitin synthesis inhibitor used as a pesticide. In insect models, the inhibitor has been shown to affect several reproductive events such as the duration of preovipostion and oviposition period, the fecundity, the viability of eggs and the duration of embryonic development, respectively. |
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| DC34657 |
Angustmycin A |
Angustmycin A is a nucleoside-analog inhibitor of GMPS (guanosine monophosphate synthase) produced by Streptomyces hygroscopius that efficiently suppresses melanoma cell invasion in vitro and tumorigenicity in immunocompromised mice. Angustmycin A may be used as an anti-melanoma agent when considering GMPS as a driver of melanoma. |
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| DC34658 |
Roxarsone |
Roxarsone is an organoarsenic feed additive and has been widely used in the poultry industry to prevent coccidiosis and improve feed efficiency. The presence of roxarsone and its degradation products results in the instability of the anaerobic methanogenic process. Roxarsone inhibits methane production, and rapidly degrades into 3-amino-4-hydroxyphenylarsonic acid (HAPA). |
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| DC34659 |
Pargyline |
Pargyline is an irreversible selective monoamine oxidase (MAO)-B inhibitor drugwith antihypertensive properties. Pargyline has been found to bind with high affinity to the I2 imidazoline receptor (an allosteric site on the MAO enzyme). |
|
| DC34660 |
Perthane |
Perthane is the diethyl derivative of common pesticide DDD. It may prevent the formation of spontaneous mammary carcinoma, and also may causes adrenocortical atrophy in humans. |
|
| DC34661 |
Simazine |
Simazine is a chlorotriazine herbicide and pesticide. It may cause testicular degeneration, neuroendocrine disruption, mammary cancer, and fetal developmental delays. |
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| DC34662 |
Chromonar hydrochloride |
Chromonar hydrochloride is a coronary vasodilator agent. It increases in transmural blood flow. |
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| DC34663 |
Narasin |
Narasin is a novel agent that inhibits dengue virus replication in vitro through non-cytotoxic mechanisms, thus indicating its potential to be further developed as a therapeutic agent.It is used for the treatment of coccidiosis from a class of protozoa. It also triggers phospholipid scrambling of the erythrocyte cell membrane, an effect partially dependent on Ca2+ entry. It has been shown to foster apoptosis of tumor cells. |
|
| DC34664 |
Zimelidine |
Zimelidine is a serotonin uptake inhibitor formerly used for depression, but was withdrawn worldwide because of the risk of Gullain-Barre syndrome associated with its use. |
|
| DC34665 |
Monensin |
Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies, particularly as an anti-tumor agent. It has an inhibitory effect on the Wnt/β-catenin signaling cascade, which may be useful when the cascade is aberrantly activated in cancer cells. Monensin is a prospective anticancer drug for therapy of neoplasia with deregulated Wnt signaling. |
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| DC34666 |
Pleuromulin |
Pleuromulin is an antibiotic that derives from a class of antibacterials with different mechanisms of action from clinically used antibacterials. This is of interest due to the rapid onset of resistance to most antibacterial drugs. It has been shown that there is rarely cross-resistance between pleuromutilin derivatives and other antimicrobial agents. |
|
| DC34667 |
Fluphenazine hydrochloride |
Fluphenazine is a antipsychotic medication. It is used in the treatment of chronic psychoses such as schizophrenia. Fluphenazine exerts its actions by blocking postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia. This prevents the actions of dopamine, thereby reducing the hallucinations and delusions that are associated with schizophrenia. It is given by mouth, injection into a muscle, or just under the skin. |
|
| DC34668 |
Sulfacarbamide |
Sulfacarbamide is an antimicrobial agent that has been investigated as a therapeutic biochemical for diabetes treatment. It may lower blood sugar. |
|
| DC34669 |
Furalaxyl |
Furalaxyl is an acylamino chiral fungicide. |
|
| DC34670 |
TEPA |
TEPA is an insect chemosterilant and an antineoplastic agent. It inhibits carcinoma growth. |
|
| DC34671 |
Blastomycin |
Blastomycin, also known as Antimycin A3, is an antigen for intradermal testing prepared from sterile filtrates of cultures of the filamentous form of Blastomyces dermatitidis. It acts as a fungicide, bactericide, and wood preservative. |
|
| DC34672 |
Trichlormethine |
Trichlormethine is a chemical irritant that causes genetic effects with human therapeutic dosage. It interferes with sperm heads through action on spermatocytes. It influences the body weight, reduces the relative weight of the testes, damages spermatogenesis in the seminiferous tubules (spermatids), causes appearance of multinucleate cells in the epididymides, and increases rate of abnormality of the heads of fully mature spermatozoa. |
|
| DC34673 |
Butralin |
Butralin is a herbicide and plant-growth-controller. |
|
| DC34674 |
Halosulfuron-methyl |
Halosulfuron-methyl is a common herbicide. |
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