| DC34583 |
gp130-agonist-2 |
gp130-agonist-2 is a brain penetrant gp130 agonist which protects against NMDA-induced toxicity and increases STAT3 phosphorylation. |
|
| DC34584 |
ADPS |
ADPS is a water-soluble modified trinder reagent. |
|
| DC34585 |
Englerin A |
Englerin A is a natural potent activator of ion channels formed by Transient Receptor Potential Canonical 4 and 5 proteins (TRPC4 and TRPC5). |
|
| DC34586 |
AG538 |
AG-538 is a PI5P4Kα inhibitor which targets the ATP site. |
|
| DC34587 |
SHIN1
Featured
|
SHIN1 is a potent dual inhibitor of human serine hydroxymethyltransferase 1/2 (SHMT1/2). |
|
| DC34588 |
AGN-192403 hydrochloride |
AGN-192403 hydrochloride is an I1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site. |
|
| DC34589 |
FlAsH-EDT2 |
FlAsH-EDT2 is a pro-fluorescent, membrane-permeable, covalent CCPGCC targeted probe. |
|
| DC34590 |
CS-1 |
CS1 is a potent inhibitor of microtubule polymerization via interaction with the colchicine-binding pocket of tubulin, inducing unique histone phosphorylation patterns distinct from those induced by colchicine. CS1 is an antimitotic. |
|
| DC34591 |
SNJ1945 |
SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin as a cardioplegia. |
|
| DC34592 |
MJ15
Featured
|
MJ-15 is a potent and selective antagonist of cannabinoid CB1 receptor. |
|
| DC34593 |
ADX-10059 Hydrochloride |
ADX10059 Hydrochloride is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator. |
|
| DC34594 |
QLT-0267
Featured
|
QLT0267 is an ATP-competitive selective inhibitor of integrin-linked kinase (ILK). |
|
| DC34595 |
PRL-3 Inhibitor I
Featured
|
PRL-3 Inhibitor I is a potent PRL-3 inhibitor with an IC50 of 0.9 μM. PRL-3 Inhibitor I shows a reduced invasion in cell-based assay. |
|
| DC34596 |
EW-7197 Hydrochloride |
EW-7197 Hydrochloride is a highly potent, selective, and orally bioavailable inhibitor of TGF-β type 1 receptor kinase. |
|
| DC34597 |
Naphthol AS-TR phosphate |
NASTRp is an inhibitor of CREB-CBP complex which possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress. |
|
| DC34598 |
SCH-D |
Vicriviroc Malate is a potent, highly selective, and orally bioavailable CCR5 antagonist. |
|
| DC34599 |
TLR7/8 agonist-5d |
TLR7/8 agonist-5d is a TLR7/8 agonist which shows prominent immunostimulatory activities. |
|
| DC34600 |
NOR3 |
FK409 is a cell permeable NO donor which produces vasorelaxation. |
|
| DC34601 |
GSK-2795039 |
GSK2795039 is the first small molecule NADPH oxidase 2 (NOX2) inhibitor. |
|
| DC34602 |
Oxathiapiprolin |
Oxathiapiprolin is a oomycete fungicide, targeting an oxysterol binding protein. |
|
| DC34603 |
Fluxapyroxad
Featured
|
Fluxapyroxad is a broad-spectrum fungicide which inhibits the succinate dehydrogenase (SQR) enzyme. |
|
| DC34604 |
Saridegib HCl |
Saridegib HCl, also known as IPI-926 HCl, is a hedgehog pathway inhibitor which inhibits smoothened. |
|
| DC34605 |
aPKCI |
aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemia-reperfusion (IR)-induced permeability. |
|
| DC34606 |
Ascofuranone |
Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODH. |
|
| DC34607 |
STAT3-IN-8 |
STAT3-IN-8 is a cell permeable JAK1/JAK2/TYK2/STAT3 activation inhibitor. |
|
| DC34608 |
R-IMPP Hydrochloride |
R-IMPP Hydrochloride is an anti-secretagogue of PCSK9, promoting uptake of LDL-C in hepatoma cells by increasing LDL-R levels and blocking PCSK9 translation. |
|
| DC34609 |
TNBG |
Tetrazanbigen is an inducer of S phase arrest and apoptosis in hepatocellular carcinoma QGY-7701. |
|
| DC34610 |
BC11 hydrobromide |
BC-11 hydrobromide is an inhibitor of Urokinase-Plasminogen Activator (uPa) which induces additional impairment of mitochondrial activity, the production of reactive oxygen species, and promotion of apoptosis. |
|
| DC34611 |
Betaine Aldehyde Chloride |
Betaine Aldehyde Chloride is an inhibitor of anaerobic choline metabolism by human gut bacteria. |
|
| DC34612 |
Thyroid Hormone Receptor Antagonist (1-850) |
TR-IN-1-850 is a selective blocker of T3 binding to both TRα and TRβ. |
|
