| DC36364 |
Neoxaline |
Neoxaline is an alkaloid fungal metabolite. |
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| DC36365 |
Rugulotrosin A |
Rugulotrosin A is an antibiotic active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus. Rugulotrosin A is inactive against Gram-negative bacteria. |
|
| DC36366 |
16:0(CE) |
Cholesteryl palmitate is a cholesterol ester used to form a stable tear film to study amphiphilic block copolymers as surfactants for dry eyes. Cholesteryl palmitate levels in amniotic fluid are decreased in pregnancies in which infants later developed respiratory distress syndrome and in patients with well-controlled diabetes. Levels of cholesteryl palmitate are increased in bronchoalveolar lavage fluid (BALF) from patients with chronic interstitial pneumonia. |
|
| DC36367 |
Pyridoxatin |
Pyridoxatin is a fungal metabolite that inhibits production of thiobarbituric acid reactive substance (TBARS). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH and is active against C. albicans. |
|
| DC36368 |
Antibiotic PF 1052 |
Antibiotic PF 1052 is a fungal metabolite active against S. aureus, S. parvulus, and C. perfringens. It inhibits neutrophil migration, reduces pseudopodia formation, and induces rounding of neutrophils. Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils. |
|
| DC36369 |
Zelkovamycin |
Zelkovamycin is a cyclic peptide antibiotic that inhibits growth of X. oryzae, P. oryzae, S. aureus, and A. laidlawii in a concentration-dependent manner. |
|
| DC36370 |
4-epi-Oxytetracycline |
Epioxytetracycline is a degradation product of the antibiotic oxytetracycline. |
|
| DC36371 |
Silodosin β-D-glucuronide |
Silodosin glucuronide sodium is an active metabolite of the α1A-adrenergic receptor antagonist silodosin. It is formed from silodosin by the UDP-glucuronosyltransferase (UGT) isoform UGT2B7. |
|
| DC36372 |
Peimisine HCl |
Peimisine HCl is a steroidal alkaloid that inhibits lung acetylcholinesterase (AChE). |
|
| DC36373 |
ABTS |
ABTS is a radical cation and a peroxidase substrate. It is used to assess antioxidant capacity in the Trolox equivalent antioxidant capacity (TEAC) assay. It is blue in the presence of sodium persulfate or metmyoglobin but decolorizes upon incubation with antioxidants, and the antioxidant capacity can be determined spectrophotometrically. ABTS has also been used as an enzyme substrate in ELISAs. Upon incubation with a peroxidase, it produces a soluble green product that can be quantified by colorimetric detection at 405 nm. |
|
| DC36374 |
(-)-Verrucofortine |
Verrucofortine is a fungal metabolite. |
|
| DC36375 |
Haloperidol Metabolite II |
Reduced haloperidol is an active metabolite of haloperidol formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake. |
|
| DC36376 |
NSC 204855 |
Steffimycin B is an anthracycline bacterial metabolite. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine. Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells. It is active against M. tuberculosis, B. cereus, and P. falciparum. |
|
| DC36377 |
Integracin B |
Integracin B is a fungal metabolite and an inhibitor of HIV-1 integrase. |
|
| DC36378 |
Tenellin |
Tenellin is a fungal metabolite that inhibits Mg2±, Ca2±, and Na+/K±ATPase activities in erythrocytes. Tenellin is cytotoxic to Sf9 and Sf21 insect cells. |
|
| DC36379 |
Antibiotic 1166C |
Hygrolidin is a macrocyclic lactone that inhibits proliferation of DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells. Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells. |
|
| DC36380 |
N-methyl Mesoporphyrin IX |
N-methyl Mesoporphyrin IX is a transition state analog of porphyrin and an inhibitor of ferrochelatase. N-methyl Mesoporphyrin IX has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence. It has also been used to detect amyloid-β (1-40) (Aβ40) fibrils in vitro and in live PC12 cells overexpressing Aβ. |
|
| DC36381 |
Mepicycline |
Pipacycline is a tetracycline antibiotic derivative. It inhibits the formation of penicillinase, the enzyme that inactivates penicillin in bacteria. It decreases oxygen uptake and inhibits growth of penicillin-resistant penicillinase-producing S. aureus. |
|
| DC36382 |
16-Deethylindanomycin |
Deethylindanomycin is a polyether antibiotic that is active against a variety of Gram-positive bacteria, including various strains of S. aureus and Streptococcus, as well as one strain of S. pneumoniae. It is also active against coccidia in vitro, inhibiting E. tenella development, but is inactive against E. tenella infection in chicks when. Deethylindanomycin acts as an ionophore in lipid bilayer membranes and is more selective for potassium ions than calcium, magnesium, and sodium ions. It induces histamine release from rodent mast cells and human basophils in vitro in a calcium-dependent manner. |
|
| DC36383 |
Dihydroherbimycin A |
TAN 420E is a bacterial metabolite that scavenges DPPH radicals and reduces thiobarbituric acid reactive substances (TBARS) liver microsomes. TAN 420E is active against B. brevis, B. cereus, M. flavus, and S. aureus. It is cytotoxic to P388 and KB lymphocytic leukemia cells. |
|
| DC36384 |
Sporidesmolide II |
Sporidesmolide II is a cyclic depsipeptide. |
|
| DC36385 |
Spinosyn A aglycone |
Spinosyn A aglycone is an aglycone form of the insecticide spinosyn A. It is formed by acid hydrolysis of spinosyn A 17-pseudoaglycone and has no insecticidal activity at concentrations up to 64 ppm. |
|
| DC36386 |
Neoaureothin |
Neoaureothin is a bacterial metabolite and androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells. It also has nematocidal activity against the pine wood nematode B. xylophilus and increases survival of P. densiflora trees inoculated with B. xylophilus. |
|
| DC36387 |
SCH 38519 |
SCH 38519 is an isochromanequinone fungal metabolite that inhibits aggregation induced by thrombin as well as serotonin secretion in human platelets. It inhibits the growth of various Gram-negative and Gram-positive bacteria. |
|
| DC36388 |
NSC 613948 |
Nybomycin is a fungal metabolite with antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae. Nybomycin is also active against M. tuberculosis and M. bovis. |
|
| DC36389 |
(±)-Avenaciolide |
Avenaciolide is a water-insoluble fungal metabolite that inhibits glutamate transport in isolated rat liver mitochondria. |
|
| DC36390 |
LysoFP-NH2 |
LysoFP-NH2 is the fluorescent form of the lysosomal turn-on fluorescent probe for carbon monoxide (CO) lysoFP-NO2. LysoFP-NH2 is formed when lysoFP-NO2 reacts with CO. It displays excitation/emission maxima of 440/528 nm, respectively. |
|
| DC36391 |
MGR2 |
MGR2 is a negative control compound for the activity of the reactive oxygen species-generating probe MGR1. Unlike MGR1, MGR2 does not induce superoxide production or cell death in HEK293T cells. |
|
| DC36392 |
Deoxyfusapyrone |
Deoxyfusapyrone is an α-pyrone fungal metabolite that has antifungal activity. It is active against C. neoformans, A. fumigatus, A. niger, and A. flavus human mycoses. Deoxyfusapyrone is also active against a variety of filamentous fungi, but not yeast or the bacterium B. megaterium. |
|
| DC36393 |
RK-682 (rac-1) |
TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682. TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B, but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces. |
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