| DC36394 |
Collismycin A |
Collismycin A is a bacterial metabolite with antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria and fungi. It inhibits proliferation of A549 lung, HCT116 colon, HeLa cervical cancer cells, and NIH373 fibroblasts but not MDA-MD-231 breast cancer cells. Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions. Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid. |
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| DC36395 |
Demethoxyviridiol |
Demethoxyviridiol is a mycotoxin that inhibits phosphatidylinositol 3-kinase (PI3K). |
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| DC36396 |
Brevicompanine B |
Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various genes involved in the regulation of plant circadian rhythm. It is active against P. falciparum. |
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| DC36397 |
MAGL Inhibitor Compound 23 |
MAGL Inhibitor Compound 23 is an inhibitor of monoacylglycerol lipase (MAGL). It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12. MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells but not MRC5 cells. It increases the levels of 2-arachidonoyl glycerol (2-AG) in mouse brain and plasma when administered at a dose of 50 mg/kg. |
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| DC36398 |
9-Methylstreptimidone |
Antibiotic TS 885 is a microbial metabolite that has antifungal and antiviral activities. It is active against several fungi, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus and has antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro. 9-Methylstreptimidone increases survival in mouse models of infection with influenza A2 (H2N2) or C. albicans when administered prior to infection. |
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| DC36399 |
K-TMZ |
K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking or expressing O6-methylguanine DNA methyltransferase (MGMT). |
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| DC36400 |
GS-2989 |
Meclocycline is a tetracycline antibiotic with broad antimicrobial activity. Meclocycline inhibits lactate dehydrogenase (LDH) release and cell toxicity induced by expression of htt-N63-148Q, a mutant form of the huntingtin gene, without altering htt-N63-148Q protein levels in PC12 cells. |
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| DC36401 |
(+)-Quinolactacin A1 |
(+)-Quinolactacin A1 is a fungal metabolite that inhibits acetylcholinesterase (AChE). |
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| DC36402 |
SPQ |
SPQ is a fluorescent chloride indicator. It has been used to assess voltage-sensitive chloride transport in placental microvillus vesicles. It has also been used to continuously quantify intracellular calcium efflux induced by parathyroid hormone, forskolin, and PMA in isolated human erythrocytes. In addition, SPQ has been used to determine the type of ion conductance induced by the cystic fibrosis transmembrane conductance regulator (CFTR) in HEK293 cells expressing pTrial10-CRTR2. |
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| DC36403 |
Acetaminophen glucuronide |
Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen. It is formed via glucuronidation of acetaminophen by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A9, UGT1A1, and UGT2B15. |
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| DC36404 |
Iloperidone metabolite P88 |
Iloperidone metabolite P88 is an active metabolite of the atypical antipsychotic iloperidone. It binds to the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT2A, and 5-HT2C, α2b- and α2c-adrenergic, and dopamine D1, D2A, and D4 receptors. |
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| DC36405 |
FINO2 |
FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron. It decreases GPX4 activity and protein levels in vitro but does not act as an active site, allosteric, or covalent inhibitor of GPX4 or alter GPX homeostasis. It also oxidizes iron in vitro, leading to degradation of the endoperoxide moiety, but does not affect the protein levels of iron regulatory proteins, such as IRP2, FTL1, or TFR. FINO2 induces lipid peroxidation of a large subset of the lipidome in HT-1080 cells when used at a concentration of 10 μM and induces ferroptosis in an arachidonic acid lipoxygenase-independent manner. It inhibits cell growth and induces lethality in the NCI-60 panel of cancer cell lines. It is selective for oncogenically transformed BJ-ELR cells over noncancerous BJ-hTERT cells. FINO2 induces oxidative stress, including lipid peroxidation, in RS4;11 B-lymphoblastic leukemia cells. It induces iron-dependent cell death, an effect that can be blocked by pretreatment with the lipophilic antioxidants ferrostatin-1 and liproxstatin-1 and does not induce markers of apoptosis, necrosis, or autophagy in RS4;11 cells. |
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| DC36406 |
BAY 67-3472 |
Sorafenib N-oxide is an active metabolite of sorafenib (BAY 43-9006), an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD. It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3. Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4. |
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| DC36407 |
BB-F-Yne |
BB-F-Yne is a cell-permeable derivative of the protein arginine diminase (PAD) inhibitor BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions. BB-F-Yne inhibits PAD1-4 and has been used for labeling PADs in cell-free and cell-based assays, followed by click reactions with azide-modified TAMRA or biotin reporters. |
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| DC36408 |
UF-17 HCl |
UF-17 HCl is an analytical reference standard that is structurally similar to known utopioids. |
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| DC36409 |
α-hydroxy Metoprolol |
α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol. It is formed via metabolism of metoprolol by the cytochrome P450 (CYP) isoform CYP2D6. |
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| DC36410 |
SF 2583A |
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs). Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB). |
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| DC36411 |
(-)-Cyclopenol |
(-)-Cyclopenol is a benzodiazepine alkaloid fungal metabolite that inhibits protein tyrosine phosphatase 1B (PTP1B). |
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| DC36412 |
BMP-22 |
BMP-22 is an inhibitor of autotaxin. It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7. BMP-22 inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC) and inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis. |
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| DC36413 |
Aspergillin PZ |
Aspergillin PZ is a fungal metabolite active against S. epidermidis but not S. aureus, E. coli, or B. cereus. It is cytotoxic to HL-60 promyelocytic leukemia cells but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells. |
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| DC36414 |
DiIC1(5) |
DiIC1(5) is a signal-off fluorescent probe for the detection of mitochondrial membrane potential disruption. It accumulates in mitochondria and its fluorescence intensity decreases when the mitochondrial membrane potential is disrupted. DilC1(5) has been used in combination with a variety of cell damage and cell death markers to classify nine stages of cell death using flow cytometry. It has also been used as a quencher for the detection of serine phosphorylation and tyrosine dephosphorylation post-translational modifications (PTMs) in quenching resonance energy transfer (QRET) and mTR-FRET applications. It displays excitation/emission maxima of 659/666 nm, respectively. |
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| DC36415 |
Calpinactam |
Calpinactam is a fungal metabolite with antimycobacterial activity. It is active against M. smegmatis. |
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| DC36416 |
LL-D 37187α |
Martinomycin is a polyether antibiotic active against a variety of bacteria including 11 strains of S. aureus, three strains of S. pneumoniae, and E. faecalis. |
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| DC36417 |
Asperparaline A |
Aspergillimide is a fungal metabolite that reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs. |
|
| DC36418 |
Abacavir carboxylate |
Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir. It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues. |
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| DC36419 |
Iloperidone metabolite P95 |
Iloperidone metabolite P95 is a metabolite of the atypical antipsychotic iloperidone. It binds to the serotonin (5-HT) receptor subtype 5-HT2A and α1-, α2B-, and α2C-adrenergic receptors but does not cross the blood-brain barrier. |
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| DC36420 |
Avanafil metabolite M4 |
Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16 as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. |
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| DC36421 |
SRS16-86
Featured
|
SRS16-86 is an inhibitor of ferroptosis. It inhibits ferroptosis induced by erastin in HT-1080 and NIH3T3 cells. SRS16-86 prevents renal tubular damage and increases in serum levels of urea and creatine in a mouse model of renal ischemia-reperfusion injury (IRI). In a rat model of spinal cord injury, SRS16-86 increases the levels of glutathione peroxidase 4 (GPX4), system xc- cystine/glutamate transporter (xCT), and glutathione (GSH) and decreases levels of IL-1β, TNF-α, ICAM-1, and the lipid peroxidation marker 4-hydroxy nonenal (4HNE) in injured spinal cord epicenters. It also increases tissue sparing and improves locomotor recovery in the same model. |
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| DC36422 |
3-hydroxy Darifenacin |
3-hydroxy Darifenacin is a metabolite of darifenacin. It is an antagonist of M1-5 muscarinic receptors. |
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| DC36423 |
Avanafil metabolite M16 |
Avanafil metabolite M16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M16 and avanafil metabolite M4 as well as minor metabolites. |
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