| DC36424 |
BODIPY 558/568 C12 |
BODIPY 558/568 C12 is a fatty acid-conjugated fluorescent probe for lipid droplets. It displays excitation/emission maxima of 558/568 nm, respectively, and has been used to monitor the localization and dynamics of lipid droplets in live cells. |
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| DC36425 |
YnMyr Diazirine X10 |
YnMyr Diazirine X10 is a cell-permeable photoreactive probe for protein myristoylation.1,2 It contains a terminal clickable alkyne moiety and a photoactivatable diazirine group at carbon 10 that allow its incorporation into myristylated proteins and photo-activated cross-linking of their interacting partners, respectively. |
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| DC36426 |
BB-Cl-Yne |
BB-Cl-Yne is a cell-permeable derivative of the protein arginine deiminase (PAD) inhibitor BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions. BB-Cl-Yne inhibits PAD1-4 and has been used for labeling PADs in cell-free and cell-based assays, followed by click reactions with azide-modified TAMRA or biotin reporters. |
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| DC36427 |
NG-25 HCl hydrate |
NG-25 HCl hydrate is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner. It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer. |
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| DC36428 |
(±)-Ketoprofen glucuronide |
(±)-Ketoprofen glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen. It is formed via glucuronidation by the UDP-glucuronosyltrasferase (UGT) isoforms UGT1A3, UGT1A9, UGT1A10, and UGT2B7. |
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| DC36429 |
Chrodrimanin B |
Chrodrimanin B is a meroterpenoid fungal metabolite with insecticidal activity against third instar silkworm larvae. |
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| DC36430 |
7-hydroxy Pyranonigrin S |
Pyranonigrin A is a fungal metabolite with antioxidant activity. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals in a cell-free assay. Pyranonigrin A suppresses TNF-α-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs). |
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| DC36431 |
(-)-Rasfonin |
(-)-Rasfonin is a fungal metabolite that inhibits proliferation of mouse splenocytes induced by concanavalin A and LPS. |
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| DC36432 |
Quinolactactin A |
Quinolactactin A is a quinolone fungal metabolite that inhibits TNF production induced by LPS in murine peritoneal macrophages. Quinolactacin A is a mixture of quinolactacin A1 and A2. |
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| DC36433 |
(+)-Macrosphelide A |
(+)-Macrosphelide A is a fungal metabolite that inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It also inhibits the growth of SKOV3 ovarian cancer cells in a concentration-dependent manner. (+)-Macrosphelide A inhibits the growth of Gram-positive bacteria, including B. subtilis, M. luteus, B. thuringiensis, and S. aureus but not Gram-negative bacteria or fungi. |
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| DC36434 |
BK223-A |
NG 012 is a fungal metabolite with fungicidal and nerve growth factor-potentiating properties. NG 012 increases the efficacy of the antifungal miconazole against C. albicans. It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner. |
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| DC36435 |
OM173-αA |
OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M. gallisepticum, M. pneumoniae, and S. aureus. OM173-αA also inhibits the growth of the plant pathogenic fungus P. oryzae and several species of Trichophyton. |
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| DC36436 |
PMPApp |
Tenofovir diphosphate sodium salt is an inhibitor of HIV reverse transcriptase and hepatitis B virus (HBV) polymerase. It is selective for these enzymes over DNA polymerase α and β, as well as mitochondrial DNA polymerase γ. Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir and tenofovir disoproxil by nucleotide kinases. Increased levels of tenofovir diphosphate in isolated peripheral blood mononuclear cells (PBMCs) correlate with a decrease in the risk of simian HIV (SHIV) acquisition in a macaque model of rectal SHIV transmission. |
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| DC36437 |
C11 BODIPY 581/591 |
C11 BODIPY 581/591 is a lipid-soluble ratiometric fluorescent indicator of lipid oxidation. Upon oxidation, its excitation maximum shifts from 581 to 500 nm and the emission maximum shifts from 591 to 510 nm. C11 BODIPY 581/591 has been used in the quantitation of ferroptosis. |
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| DC36438 |
(+)-Ambuic Acid |
Ambuic acid is a cyclohexanone that has phytopathogenic antifungal, quorum sensing inhibitory, and antibacterial activities. Ambuic acid inhibits the biosynthesis of cyclic peptides involved in quorum sensing, including gelatinase biosynthesis-activating pheromone (GBAP) in E. faecalis, autoinducing peptide I (AIP-I) in S. aureus, and LsrD698 and LsrD826 in L. innocua. It suppresses abcess formation in a mouse model of skin infection induced by methicillin-resistant S. aureus (MRSA) when administered at a dose of 5 μg and decreases the activity of the agr quorum sensing system in an in vivo reporter assay. |
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| DC36439 |
Bostrycin |
Bostrycin is an anthraquinone with antibacterial, antiproliferative, and phytotoxic properties. It is active against Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Bostrycin inhibits proliferation of A549 lung adenocarcinoma cells as well as halts the cell cycle at the G0/G1 phase and induces apoptosis in A549 cells. Bostrycin has been used as a cross-linking agent for protein immobilization that retains bacteriostatic activity when immobilized on nonwoven polypropylene fabric. |
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| DC36440 |
SGK1 inhibitor |
SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719. |
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| DC36441 |
(+)-Laudanosine |
(S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium. It inhibits prolyl endopeptidase and inhibits both arachidonic acid- and collagen-induced aggregation in washed rabbit platelets. |
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| DC36443 |
DC-Chol
Featured
|
DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with DOPE, has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice. |
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| DC36444 |
(±)-Tocol |
(±)-Tocol is a synthetic vitamin E derivative. Unlike (±)-α-tocopherol, (±)-tocol does not suppress retinol-induced erythrocyte hemolysis or increase microviscosity of rat liver phosphatidylcholine (PC) liposomes. |
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| DC36445 |
Dihydrotetrabenazine |
Dihydrotetrabenazine (racemic) is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum and inhibits synaptic vesicular serotonin (5-HT) uptake. It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta. Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum. |
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| DC36446 |
(±)-γ-Tocopherol |
(±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays. It also reduces the synthesis of prostaglandin E2 (PGE2) induced by LPS in RAW 264.7 macrophages and by IL-1β in A549 cells. (±)-γ-Tocopherol inhibits LPS-induced nitrite release and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells and reduces COX-2 activity in A549 cells pretreated with IL-1β. Serum levels of (±)-γ-tocopherol are decreased in patients with cardiovascular disease. |
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| DC36447 |
N-methyl Paroxetine |
N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes. It inhibits serotonin (5-HT) uptake in rat brain synaptosomes and has been used as a precursor in the synthesis of paroxetine. |
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| DC36448 |
Aburamycin A |
Chromomycin A2 is an aureolic acid that has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of human SGC7901 gastric cancer, HepG2 hepatocellular carcinoma, A549 lung epithelial adenocarcinoma, HCT116 colon cancer, and COC1 ovarian cancer cells, as well as human umbilical vein endothelial cells (HUVECs). Chromomycin A2 halts the cell cycle in the G0/G1 phase and increases the protein levels of LC3A and LC3B in MALME-3M melanoma cells. This indicates that it induces autophagy. It also increases the levels and promoter activity of the autophagic proteins ATG7 and ATG10 and reduces cell viability to 50% in human SCC-11 squamous cell carcinoma cells when used at a concentration of 30 nM. |
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| DC36449 |
Territrem B |
Territrem B is a mycotoxin that irreversibly inhibits acetylcholinesterase (AChE). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg. |
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| DC36450 |
Terpendole C |
Terpendole C is an indole diterpene alkaloid fungal metabolite and inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT). It also inhibits ACAT in J774 macrophages without affecting cell growth. |
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| DC36451 |
p-APMSF |
p-APMSF is an irreversible inhibitor of serine proteases. |
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| DC36453 |
Tetrahydropiperine |
Tetrahydropiperine is a piperine derivative that has diverse biological activities. It is an agonist of transient receptor potential vanilloid type 1 (TRPV1). It inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH) and 7-methoxycoumarin O-demethylase (MOCD) activity in rat liver microsomes. |
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| DC36454 |
Carboxyibuprofen |
Ibuprofen carboxylic acid is a major metabolite of ibuprofen. |
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| DC36455 |
24-norUrsodeoxycholic acid |
Norucholic acid is a Ursodeoxycholic Acid (U850000) derivative. It is superior to Ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. |
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