| DC36455 |
24-norUrsodeoxycholic acid |
Norucholic acid is a Ursodeoxycholic Acid (U850000) derivative. It is superior to Ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. |
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| DC36456 |
DMPAC-Chol |
DMPAC-Chol is a cationic cholesterol derivative that has been used in liposome formation for gene transfection. Liposomes containing DMPAC-chol bind to DNA in a band shift assay and protect against serum nuclease degradation of DNA. |
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| DC36457 |
Febuxostat acyl glucuronide |
Febuxostat acyl glucuronide is a metabolite of the xanthine oxidoreductase inhibitor febuxostat. Febuxostat acyl glucuronide is formed via glucuronidation of febuxostat by uridine diphosphate-glucuronosyltransferases (UGTs). |
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| DC36458 |
NCI 240899 |
True Blue is a fluorescent neuronal retrograde tracer that labels the nucleus, nucleolus, cell body, proximal dendrites, and axons of neurons. It displays excitation/emission maxima of 373/404 nm, respectively. |
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| DC36459 |
DMHAPC-Chol |
DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells. DMHAPC-Chol, as part of a lipoplex with DOPE, has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF. |
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| DC36460 |
(±)-β-Tocopherol |
(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and inhibits LPS-induced COX-2 gene expression. Unlike (±)-α-tocopherol, (±)-β-tocopherol does not inhibit smooth muscle cell proliferation, decrease PKC activity, increase phosphoprotein phosphatase 2A (PP2A) activity, or modify expression of the α-tropomyosin gene. |
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| DC36461 |
Hydroxystilbamidine |
Hydroxystilbamidine is a fluorescent neuronal retrograde tracer that labels the neuronal cell body as well as proximal dendrites. It is also a nucleic acid dye that can be used to label DNA and RNA in fixed or unfixed dead cells. It displays an excitation maximum of 360 nm and emission maxima of 450 and 600 nm when bound to DNA but only emits at 450 nm when bound to RNA. |
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| DC36462 |
Moxifloxacin N-sulfate |
Moxifloxacin N-sulfate is a metabolite of Moxifloxacin --- a fluoroquinolone antibiotic. Formulations containing moxifloxacin have been used in the treatment of bacterial infections such as sinusitis, chronic bronchitis, and pneumonia. |
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| DC36463 |
Sitagliptin N-sulfate |
Sitagliptin N-sulfate is a phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin. Sitagliptin N-sulfate is formed via sulfation. |
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| DC36464 |
Avermectin B1a monosaccharide |
Avermectin B1a monosaccharide is a macrolide anthelmintic and monosaccharide form of avermectin B1a. |
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| DC36465 |
Corynecin V |
Corynecin V is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium. |
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| DC36466 |
Di-4-ANEPPS |
Di-4-ANEPPS is a potentiometric fluorescent dye that can be used to measure membrane potential. It displays absorption/emission maxima of 495/705 nm, respectively. The relative fluorescence changes proportionally to membrane potential at a rate of approximately 10% per 100 mV. Di-4-ANEPPS has been used to measure membrane potential in a variety of tissue and cell types as well as artificial membranes. |
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| DC36467 |
CI-898 HCl |
CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia. |
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| DC36468 |
4-hydroxy Nebivolol HCl |
4-hydroxy Nebivolol HCl is a major metabolite of nebivolol. It is formed by the hydroxylation of nebivolol by the cytochrome P450 (CYP) isoform CYP2D6. |
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| DC36469 |
N-desmethyl Rosuvastatin sodium salt hydrate |
N-desmethyl Rosuvastatin sodium salt hydrate is an active metabolite of the HMG-CoA reductase inhibitor Rosuvastatin. N-desmethyl Rosuvastatin is formed when Rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4. |
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| DC36470 |
ARN14988 |
ARN14988 is a potent inhibitor of acid ceramidase that increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells. |
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| DC36471 |
CAY10734 |
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors but does also bind S1P5 receptors in radioligand binding assays. CAY10734 reduces peripheral blood lymphocytes and increases graft survival in a rat skin allograft model combination with cyclosporin A (CsA). |
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| DC36472 |
Bromosulfalein |
Bromosulfalein has been commonly used as both a substrate and inhibitor of organic anionic transporting polypeptide 1B1 (OATP1B1), OATP1B3, OATP1A2, and OATP2B1, as well as multidrug resistance protein 2 (MDR2). It has also been used for in vivo studies of liver and biliary system function and as an anionic dye for the quantitative estimation of protein levels in tissue homogenates or purified samples. |
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| DC36473 |
Chloroguanabenz acetate |
Chloroguanabenz acetate is an antiprion agent. It is derived from the α2-adrenergic receptor agonist guanabenz. Chloroguanabenz reduces the levels of both soluble and aggregated forms of the truncated Huntingtin derivative Htt48 in an HEK293T cellular model of Huntington’s disease. |
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| DC36474 |
BODIPY 505/515 |
BODIPY 505/515 is a lipophilic fluorescent probe that localizes to intracellular lipid bodies and has been used to label lipid droplets. BODIPY 505/515 has been used for electron, epifluorescent, and confocal microscopy, as well as flow cytometry applications in various algae species. It displays excitation/emission maxima of 505/515 nm, respectively, and has been used for live and fixed cell applications. |
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| DC36475 |
APAP-Cys |
3-Cysteinylacetaminophen TFA salt is an acetaminophen-protein adduct formed during the metabolism of acetaminophen. In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels --- an effect that can be blocked by the γ-glutamyl inhibitor acivicin. |
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| DC36476 |
6-Aminophenanthridine |
6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz. 6-Aminophenanthridine inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate. It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 μM and in adults following dietary administration of 1-3 mM doses. 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD. |
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| DC36477 |
Olanzapine N-oxide |
Olanzapine N-oxide is a metabolite of Olanzapine. Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder. |
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| DC36478 |
2-ATHBI |
2-ATHBI, also known as 2-Acetyl-4-tetrahydroxybutyl Imidazole or THI, is an inhibitor of S1P lyase. |
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| DC36479 |
2,2'-Dipyridyl disulfide |
2,2'-Dipyridyl disulfide, also known as OPSS, is a useful reagent for determination of sulfhydryl groups, preparation of amino acid active esters and the thio esters of phosphoric acid. It acts as a peptide coupling reagent and as an oxidizing agent. It is also used for the activation of glycosides. |
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| DC36480 |
JNK-IN-7
Featured
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JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C. |
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| DC36482 |
Gymnemic Acid I |
Gymnemic acids have been reported to effect a natural treatment for diabetes. Gymnemic acids inhibit rabbit glyceraldehyde-3-phosphate dehydrogenase and induce a smearing of its electrophoretic band and dephosphorylation. Gymnemic Acid Stimulates In Vitro Splenic Lymphocyte Proliferation. |
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| DC36483 |
Oseltamivir carboxylate hydrochloride |
Oseltamivir carboxylate is an active metabolite of oseltamivir phosphate (Tamiflu). |
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| DC36485 |
Isocyclosporin A |
Isocyclosporin A is a rearranged degradation product formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions. |
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| DC36486 |
Spiromesifen |
Spiromesifen is a useful insecticide and miticide in plant breeding. It is particuarly useful against spider mites and whiteflies in vitro. |
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