| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23558 | (+)-NFPS | A potent, selective GlyT1 inhibitor that demonstrates >10-fold greater activity in in vitro functional glycine reuptake assay than racemic (±)-NFPS. |
|
| DC20400 | HDAC1,2-IN-2 | A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively. |
|
| DC21373 | HDAC6 inhibitor NCT-14b | A potent, selective HDAC6 inhibitor with IC50 of 84 nM, with IC50s of >3.5 uM for the other HDAC isoforms.. |
|
| DC21461 | PD-118057 | A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells. |
|
| DC22946 | ML-T531 Featured | ML-T531 is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM. |
|
| DC22990 | HIF1-IN-2 | A potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB. |
|
| DC25054 | Gambogic amide | A potent, selective high affinity TrkA receptor agonist with Kd of 75 nM. |
|
| DC22966 | ABH hydrochloride Featured | A potent, selective human Arginase inhibitor with Ki of 0.25 uM (pH=7.5), 8.5 nM (pH=9.5) for type II arginase. |
|
| DC22454 | IMPDH2-IN-5 | A potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with IC50 of 620 nM (inhibition of NO production). |
|
| DC20345 | CLK inhibitor 2 | A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively. |
|
| DC22897 | KRH-1636 | A potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5. |
|
| DC22847 | L-870810 | A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties. |
|
| DC23189 | CL-82198 Featured | CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression. |
|
| DC22658 | Windorphen | A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM). |
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| DC22625 | Rolipram Featured | A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. |
|
| DC23910 | Microcystin-LR | A potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM. |
|
| DC22754 | SKA-111 | A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM. |
|
| DC23551 | PF-05388169 | A potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM). |
|
| DC23550 | PF-05387252 | A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM). |
|
| DC22677 | (±)-U-50488 hydrochloride | A potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects. |
|
| DC22858 | LIMK-IN-14 | A potent, selective LIMK inhibitor with IC50 of 0.9 nM and 0.5 nM and 1.2 nM for LIMK1 and LIMK2, respectively. |
|
| DC22859 | LIMK-IN-22j | A potent, selective LIMK inhibitor with IC50 of 3.2 nM and 1.2 nM for LIMK1 and LIMK2, respectively. |
|
| DC24026 | LPA2-IN-1 | A potent, selective LPA2 (EDG4) antagonist with IC50 of 17 nM. |
|
| DC22364 | DG051 | A potent, selective LTA4H (Leukotriene A4 hydrolase) inhibitor (IC50/Kd=47/25 nM) of leukotriene B4 biosynthesis. |
|
| DC20722 | AZD-1979 | A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM. |
|
| DC26072 | BMS 819881 | A potent, selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 10.4 nM. |
|
| DC22710 | LY3020371 hydrochloride | A potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively. |
|
| DC22921 | AMN 082 | A potent, selective mGluR7 allosteric agonist that inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64±32 nM. |
|
| DC21573 | Ro 5212773 Featured | EPPTB is a selective antagonist of the trace amine-associated receptor 1 (TAAR1). |
|
| DC24163 | XEN-907 | A potent, selective NaV1.7 blocker with IC50 of 3 nM. |
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