| DC23027 |
INP-0400 |
A small-molecule inhibitor of type III secretion in Y. pseudotuberculosis, without affecting in vitro multiplication, causes a dose- and growth phase-dependent inhibition of C. trachomatis RB multiplication.. |
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| DC22553 |
KIN-1408 |
A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus). |
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| DC22799 |
ML-162
Featured
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A small-molecule probe that selectively kills cells induced to express mutant RAS. |
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| DC22800 |
ML-210
Featured
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A small-molecule probe that selectively kills cells induced to express mutant RAS. |
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| DC21029 |
Fusicoccin-A |
A small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1. |
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| DC22854 |
PhiKan-083 |
A small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM. |
|
| DC23009 |
Gue-1654 |
A small-molecule that inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R in both recombinant and human primary cells. |
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| DC20886 |
CGP-049090 |
A small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines. |
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| DC22392 |
BRD-4592
Featured
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BRD4592 is a small-molecule allosteric inhibitor that targets the tryptophan synthase (TrpAB) of Mycobacterium tuberculosis. TrpAB is a bifunctional enzyme composed of α and β subunits, which catalyzes the final steps of tryptophan biosynthesis. BRD4592 binds at the interface of the α and β subunits, disrupting the enzyme's function. |
|
| DC21831 |
Tepilamide fumarate |
A small-molecule, fumaric acid ester (FAE) compound that is a prodrug of methyl hydrogen fumarate (also known as monomethyl fumarate), for the treatment of relapsing-remitting multiple sclerosis and plaque psoriasis.. |
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| DC21244 |
LMP-420 |
A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells. |
|
| DC26093 |
PH-064
Featured
|
A sodium channel inhibitor.. |
|
| DC24093 |
PF-915275
Featured
|
PF-915275 is a potent and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) (Ki ＜ 1 nM) with good preclinical pharmacokinetic properties.IC50 value: ＜ 1 nM (Ki)[2]Target: 11βHSD1in vitro: PF-915275 maintains potency in our cellular assay against human 11βHSD1 (HEK293, EC50 = 5 nM) and is selective against human 11βHSD2 (HEK293, 1.5% inhibition 10 μM). PF-915275 displays only weak affinity for the rodent choline transporter (Ki = 9.6 μM) and the hamster melatonin MT3 receptor (Ki = 9.6 μM) in the Cerep Bioprint screening panel. PF-915275 has good in vitro pharmacokinetic properties. In particular, PF-915275 is categorized as a low clearance compound (liver microsome assays) with high permeability (Caco2 assay). [2]in vivo: As a prelude to in vivo studies with PF-915275, the rat pharmacokinetic properties of this compound were determined. PF-915275 has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. [2] |
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| DC22642 |
Sibiriline |
A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3. |
|
| DC21394 |
NOFD |
A specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM). |
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| DC23022 |
PDZ1i
Featured
|
A specific inhibitor of MDA-9/Syntenin activity that inhibits MDA-9/Syntenin binding to EGFRvIII. |
|
| DC23589 |
CGP 37157
Featured
|
A specific inhibitor of mitochondrial Na(+)-Ca(2+) exchanger (mNCE) with IC50 of 1.5 uM in INS-1 cells. |
|
| DC22633 |
SB 203580 hydrochloride |
A specific p38 MAPK inhibitor with IC50 of 0.6 uM. |
|
| DC22835 |
SCH 350581 |
A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry.. |
|
| DC22830 |
SCH 350581 dihydrochloride |
A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry.. |
|
| DC20361 |
Difopein |
A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity. |
|
| DC22803 |
M-443 |
A specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl. |
|
| DC11510 |
FR-900359 |
A specific, membrane-permeable inhibitor of Gq signaling. |
|
| DC20643 |
ADDA 5 |
A specific, non-competitive, small molecule cytochrome c oxidase (CcO or complex IV) inhibitor with IC50 of 18.93 uM (CcO from human glioma). |
|
| DC23301 |
Bax activator compound 106 |
A specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis. |
|
| DC24150 |
Griseofulvin |
A spirocyclic fungal natural product used in treatment of fungal dermatophytes.. |
|
| DCAPI1583 |
liranaftate |
A squalene epoxidase inhibitor that is used as an antifungal agent. |
|
| DC22669 |
ONO-1301
Featured
|
A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase. |
|
| DC26088 |
Stauprimide |
A staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription. |
|
| DC22385 |
Adrenosterone |
A steroid hormone with a weak androgenic effect, and an intermediate/prohormone of 11-ketotestosterone.. |
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