| DC22831 |
VU 0038882 |
A small molecule activator of S. aureus HssRS (heme sensor system) that induces endogenous heme biosynthesis by perturbing central metabolism. |
|
| DC23648 |
TKN2 |
A small molecule allosteric inhibitor of TREK channels with IC50 of 3.8, 1.7 and 10.3 uM for TREK-1, TREK-2 and TRAAK, respectively.. |
|
| DC23585 |
28NH |
A small molecule allosteric inhibitor of TREK channels with IC50 of 5.0, 5.0 and 11.8 uM for TREK-1, TREK-2 and TRAAK, respectively.. |
|
| DC23582 |
TKN1 |
A small molecule allosteric inhibitor of TREK channels with IC50 of 6.5, 4.4 and 15.7 uM for TREK-1, TREK-2 and TRAAK, respectively.. |
|
| DC23241 |
TAME |
A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1). |
|
| DC11655 |
ABO dihydrochloride |
A small molecule ANXA7 GTPase activity inhibitor, induces mouse ESCs differentiation to VECs. |
|
| DC24017 |
SMER-18 |
A small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein. |
|
| DC23190 |
LM22A-4 |
A small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not p75. |
|
| DC25021 |
Endosidin-2
Featured
|
A small molecule binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex (Kd=253 uM), resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking.. |
|
| DC22842 |
DMJ-I-228 |
A small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM.. |
|
| DC22524 |
ZSET1446 |
A small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons. |
|
| DC20445 |
Me6TREN |
A small molecule Cu complexing ligand used for atom transfer radical polymerization (ATRP). |
|
| DC21067 |
TB-03 |
A small molecule Grb2 SH2 domain binding antagonist that synergistically enhances inhibition of K562 leukemia cell proliferation by imatinib (CI=0.774). |
|
| DC22843 |
DDX3-IN-16d
Featured
|
A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3), a human host factor required for the replication of several DNA and RNA viruses. |
|
| DC23010 |
R-59949(R-59-949)
Featured
|
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets. |
|
| DC23017 |
R 59022
Featured
|
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets. |
|
| DC24022 |
NSC-305787 hydrochloride |
A small molecule inhibitor of Ezrin with Kd of 5.85 uM. |
|
| DC23826 |
UC-857993 |
A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction. |
|
| DC23810 |
UC-773587 |
A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction. |
|
| DC25040 |
Heclin |
A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively. |
|
| DC22838 |
SCH 351125 |
A small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor. |
|
| DC25031 |
C2-8 |
A small molecule inhibitor of polyglutamine (polyQ) aggregation in Huntington's disease neurons. |
|
| DC22761 |
NCI-83633
Featured
|
A small molecule inhibitor of PP2C that activates extensive 3' cleavage at a concentration 50-fold below that required by fluoride or CP.. |
|
| DC22552 |
IC-87201
Featured
|
A small molecule inhibitor of PSD-95/nNOS interaction with IC50 of 31 uM, without inhibiting nNOS catalytic activity. |
|
| DC20360 |
DIDS |
A small molecule inhibitor of RAD51-mediated homologous recombination. |
|
| DC25034 |
Lin28-IN-1632 |
A small molecule inhibitor of RNA binding protein Lin28 that blocks the Lin28/let-7 interaction, rescues let-7 processing and function in Lin28-expressing cancer cells. |
|
| DC23774 |
MS-444 |
A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 7 nM. |
|
| DC23773 |
Okicenone |
A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 90 nM. |
|
| DC22852 |
Sortase-IN-6e |
A small molecule inhibitor of Staphylococcus aureus sortase with IC50 of 9.3 uM. |
|
| DC22984 |
IT-603
Featured
|
A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays. |
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