DC20171 |
Alloxazine;Isoalloxazine |
Alloxazine is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor. |
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DC12060 |
all-trans-4-Oxoretinoic acid |
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). |
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DCAPI1478 |
Almotriptan |
Almotriptan |
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DCAPI1579 |
Alogliptin |
Alogliptin |
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DC5076 |
Alogliptin Benzoate
Featured
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Alogliptin is an orally administered, anti-diabetic drug in the DPP-4 inhibitor class. A randomized clinical trial reporting in 2011 aimed to determine the efficacy and safety of alogliptin versus placebo and voglibose among newly diagnosed Type 2 diabete |
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DC10735 |
Alovudine
Featured
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Alovudine is a DNA polymerase subunit gamma-1 (POLG) inhibitor, shows promise for treating AML. |
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DC9920 |
alpha-Hederin
Featured
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alpha-hederin is a water-soluble pentacyclic triterpenoid saponin, possessing several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation. |
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DC23079 |
α-mangostin
Featured
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Alpha-Mangostin has neuroprotective, anti-cancer, antifungal, neuroprotective, renoprotective, antioxidant and anti-inflammatory activities. |
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DC20940 |
Alprazolam |
Alprazolam (D-65MT, U 31889) is a triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. |
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DC26001 |
Alprenolol
Featured
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Alprenolol is a non-selective beta blocker as well as 5-HT1A receptor antagonist. |
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DCAPI1328 |
Alprostadil(Caverject)
Featured
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Alprostadil(Caverject) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases. |
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DC12656 |
Alrestatin
Featured
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Alrestatin is an AKR (aldose reductase) inhibitor, which attaches molecules to the active site of the NADP+/enzyme complex in a stacked formation. |
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DC8366 |
ALS22335
Featured
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ALS-22335 is an anti-virus compound. |
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DC23098 |
ALS-8112 |
ALS-8112 is a potent, selective RSV polymerase inhibitor, the 5'-triphosphate of ALS-8112 (ALS-8112-TP) inhibits RSV polymerase(IC50=20 nM) without appreciable inhibition of human DNA and RNA polymerases. |
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DC23144 |
ALS-8176 |
ALS-8176 (Lumicitabine) is the 3',5'-di-O-isobutyryl prodrug of ALS-8112 5'-triphosphate (ALS-8112-TP), which is a potent, selective RSV polymerase inhibitor with IC50 of 20 nM. |
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DCAPI1290 |
Altretamine (Hexalen) |
Altretamine (Hexalen) |
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DC7079 |
Alvelestat (AZD9668)
Featured
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Alvelestat (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE) with the pIC50 of 7.9 for Human NE. |
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DCAPI1250 |
Alverine Citrate |
Alverine citrate is a drug used for functional gastrointestinal disorders. |
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DC23849 |
ALW-II-49-7 |
ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2). |
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DC23604 |
ALX-5407 hydrochloride
Featured
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ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM. |
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DC22431 |
AM432 sodium |
AM 432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2. |
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DC23485 |
AM-5262 |
AM-5262 is a potent full GPR40 (FFA1) agonist with EC50 of 81 nM. |
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DC23435 |
AM-6226 |
AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM. |
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DC9447 |
AM679 |
AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. |
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DC8958 |
Amantadine HCl |
Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug. |
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DC10372 |
Amcasertib(BBI503)
Featured
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Amcasertib(BBI503) is an orally administered investigational agent designed to inhibit cancer stem cell pathways, including Nanog, by targeting stemness kinases. |
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DC20792 |
Amelubant |
Amelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist, inhibits LTB4-induced mouse ear inflammation with ED50 of 0.008 mg/kg (p.o.). |
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DC7356 |
Ametantrone
Featured
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Ametantrone is a new anthracenedione antineoplastic agents, produced a concentration-dependent inhibition of hepatic microsomal lipid peroxidation. |
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DC9457 |
AMG 837 (calcium hydrate) |
AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
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DC20660 |
AMG-076 |
AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM). |
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