| DC24164 |
Proparacaine hydrochloride |
An irreversible local anesthetic. |
|
| DC22612 |
Afatinib
Featured
|
An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively. |
|
| DC22576 |
MSI-1436 |
An non-competitive, allosteric inhibitor of PTP1B with Ki of 0.6 uM for PTP1B1-405. |
|
| DC11911 |
Rovazolac
Featured
|
Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1. |
|
| DC22997 |
BI-653048 |
An oral glucocorticoid agonist for the treatment of rheumatoid arthritis.. |
|
| DC24069 |
CI-947
Featured
|
An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo.. |
|
| DC23721 |
Metribolone |
An orally active anabolic-androgenic steroid and a 19-nortestosterone derivative that has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR.. |
|
| DC11934 |
LQB-118 |
An orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo. |
|
| DC24141 |
Lexibulin dihydrochloride |
An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. |
|
| DC23019 |
PACMA 31
Featured
|
An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI. |
|
| DC22713 |
L-733060 |
An orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM. |
|
| DC22690 |
L-733060 hydrochloride |
An orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM. |
|
| DC21705 |
STX-213 |
An orally active, second-generation steroid sulfatase inhibitor with IC50 of 0.5 nM. |
|
| DC22943 |
Laniquidar |
An orally active, third-generation P-glycoprotein inhibitor that inhibits the drug efflux pump P-glycoprotein, resulting in higher concentrations of antineoplastic agents in tumor cells that are multi-drug resistant due to the overexpression of P-glycopro |
|
| DC22793 |
PF 04942847 |
An orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM. |
|
| DC21242 |
LM11A-31 dihydrochloride
Featured
|
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors. |
|
| DC20609 |
Elobixibat |
An orally available, potent and selective ileal bile acid transporter (IBAT) inhibitor for the treatment of constipation.. |
|
| DC23854 |
Vorolanib |
An orally available, small molecule dual VEGFR/PDGFR kinase inhibitor with antiangiogenic and antineoplastic activities. |
|
| DC23240 |
Athidathion |
An organophosphate insecticide agent.. |
|
| DC24132 |
Haloxon |
An organophosphorus anthelmintic used against nematodes of the abomasum and small intestine in ruminants. . |
|
| DC24008 |
Eperezolid
Featured
|
An oxazolidinone antibiotic that possesses potent antimicrobial activity in vitro and in vivo.. |
|
| DC20418 |
InS3-54
Featured
|
An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3. |
|
| DC22570 |
eN-IN-1 |
An α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 29 nM for rat recombinant eN. |
|
| DC20307 |
AN-12-H5 |
AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM. |
|
| DC12168 |
AN2718 |
AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism. |
|
| DC9429 |
Anagliptin |
Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9.
|
|
| DC9580 |
Anagrelide (hydrochloride) |
Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.
|
|
| DCAPI1425 |
Anastrozole
Featured
|
Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition. |
|
| DC20085 |
Androgen receptor modulators 1 |
Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM. |
|
| DC12143 |
Anemarrhenasaponin I |
Anemarrhenasaponin I, a traditional Chinese medicine, is isolated from Anemarrhena asphodeloides Bunge. |
|
