| DC12113 |
Anemarsaponin E |
Anemarsaponin E is extracted from Anemarrhena asphodeloides Bunge and has anti-inflammatory activity. |
|
| DC24123 |
Angiotensin 1-7 |
Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM. |
|
| DC9348 |
Angiotensin II human |
Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.
|
|
| DC24109 |
Anguizole |
Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM. |
|
| DCAPI1490 |
Anidulafungin
Featured
|
Anidulafungin |
|
| DC20670 |
ANT431
Featured
|
ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively). |
|
| DC20671 |
ANT431 sodium |
ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively). |
|
| DC23276 |
Antimalarial compound 49c |
Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM. |
|
| DC20308 |
Antimycin A |
Antimycin A is an inhibitor of cellular respiration, specifically oxidative phosphorylation, binds to the Qi site of cytochrome c reductase, disrupts the Q-cycle of enzyme turn over. |
|
| DC8959 |
Antipyrine |
Antipyrine is an analgesic and antipyretic agent |
|
| DC22094 |
ANY1 |
ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA). |
|
| DC20078 |
AP1867
Featured
|
AP1867 is a synthetic FKBP12F36V-directed ligand. |
|
| DC22207 |
AP1903
Featured
|
AP1903 (Rimiducid, AP-1903) is a potent, specific synthetic ligand of FKBP Phe36Val mutant (F36V-FKBP) with binding IC50 of 1.8 nM. |
|
| DC8581 |
AP219 |
AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion. |
|
| DC5198 |
ALK-IN-1 (Brigatinib analog)
Featured
|
ALK-IN-1 (Brigatinib analog) is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1. |
|
| DC12705 |
APA modulator T4 |
APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts. |
|
| DC12706 |
APA modulator T5 |
APA modulator T5 is a small modulator of alternative polyadenylation (APA), modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts. |
|
| DC12636 |
Apararenone
Featured
|
Apararenone (MT-3995) is a novel potent, selective non-steroidal mineralocorticoid receptor antagonist for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.. |
|
| DC8465 |
Apatinib (free base)
Featured
|
Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. |
|
| DC20310 |
Apcin
Featured
|
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
|
| DC8804 |
APD597(JNJ-38431055)
Featured
|
APD597(JNJ-38431055) is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. |
|
| DC22430 |
APD916 |
APD916 is a potent and selective antagonist of the H3 receptor with Ki of 0.7 nM for rH3R. |
|
| DC11077 |
Azelaprag |
apelin receptor. |
|
| DC21448 |
Apicidin
Featured
|
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay. |
|
| DC8276 |
Apilimod mesylate
Featured
|
Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
|
| DC23406 |
Aplaviroc |
Aplaviroc (GSK-873140. |
|
| DC23522 |
Aplaviroc HCl
Featured
|
Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5. |
|
| DC25100 |
Apogossypol |
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively. |
|
| DC23901 |
R-(-)-Apomorphine
Featured
|
Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.. |
.jpg)
|
| DC10122 |
Apoptozole
Featured
|
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. |
|
