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Cat. No. Product Name Field of Application Chemical Structure
DC23371 NI-42 Featured NI-42 is a potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM, with excellent selectivity over nonclass IV BRDs; weakly inhibits BRPF2 (BRD1), BRPF3, BRD9 and BRD4 (BD1) with IC50 of 48, 260, 310 and 4500 nM respectively, and no activity for ATAD2A/2B (IC50>100 uM); shows a modest (GI50=1-10 uM) and selective inhibition of proliferation of certain cancer lines, particularly those lines exhibiting monocytic lineage differentiation; a novel, structurally orthogonal chemical probe for the BRPFs suitable for cellular and in vivo studies.
DC24158 Rofecoxib A potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells.
DC20810 Pexacerfont A potent, selective and orally active CRF1 receptor antagonist with IC50 of 6.1 nM, >1,000-fold selectivity over CRF-binding protein and biogenic amine receptors.
DC20923 CP 376395 hydrochloride A potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).
DC20689 ASB 14780 A potent, selective and orally active cytosolic phospholipase A2α (cPLA2α) inhibitor with IC50 of 20 nM.
DC21689 SR 142948A Featured A potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM.
DC23621 YM543 A potent, selective and orally active SGLT2 inhibitor with IC50 of 8.9 nM, 280-fold selectivity over SGLT1.
DC21842 Darexaban A potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM.
DC21718 T-3364366 A potent, selective and orally available inhibitor of delta-5 desaturase (D5D) with Ki of <2.7 nM and IC50 of 19 nM, with excellent selectivity over D6D and SCD.
DC20768 Tonapofylline A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.
DC22682 INCB9471 A potent, selective and orally bioavailable CCR5 antagonist IC50 of 6.5 nM, Kd of 3.1 nM in human PBMCs.
DC23643 JNJ 54166060 A potent, selective and orally bioavailable P2X7 receptor with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively.
DC21600 S1P Lyase inhibitor 31 A potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM.
DC23207 JNJ-17203212 Featured A potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively.
DC21464 Eribaxaban A potent, selective and orally efficacious factor Xa (FXa) inhibitor with IC50 of 0.32 nM.
DC25047 Calphostin C A potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM.
DC20602 5F 203 Featured A potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
DC21576 RO-5508887 A potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin.
DC21103 GW405833 hydrochloride A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
DC20658 AM1241 Featured A potent, selective cannabinoid receptor CB2 agonist with Ki of 7.1 nM, >80-fold selectivity over CB1 receptors in radioligand binding assay.
DC21376 NESS-0327 A potent, selective CB1 cannabinoid receptor antagonist with Ki of 350 fM, >60,000-fold selective for the CB1 receptor versus CB2 receptor (Ki=21 nM).
DC23357 CBP bromodomain inhibitor a potent, selective CBP bromodomain inhibitor with IC50 of 69 nM, displays exquisite selectivity over BRD4(1) (IC50=18 uM) and the broader bromodomain family..
DC22697 PF-04756956 A potent, selective CCK1 receptor agonist with EC50 of 0.47 nM.
DC21393 nNOS-IN-25 A potent, selective cell permeable neuronal nitric oxide synthase (nNOS) inhibitor with Ki of 30 nM.
DC20633 ACG-548B A potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 0.12 uM, >400-fold selectivity over ChoKβ.
DC20632 ACG-416B A potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 0.13 uM, >385-fold selectivity over ChoKβ.
DC21741 RSM-932A A potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.0 uM, 33-fold selectivity over ChoKβ.
DC22917 SCH 79797 dihydrochloride Featured A potent, selective competitive and nonpeptide PAR-1 antagonist with IC50 of 70 nM.
DC20580 Vitacoxib A potent, selective COX-2 inhibitor with IC50 of 0.34 ug/mL, >50-fold selectivity over COX-1 (IC50=19.4 ug/mL).
DC22418 CCX-771 A potent, selective CXCR7 antagonist with IC50 of 4.1 nM.

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