SR 142948A|cas 184162-21-8|DC Chemicals

Cas No.:	184162-21-8
Synonyms:	2-[[5-(2,6-dimethoxyphenyl)-1-(4-(N-(3-dimethylaminopropyl)-N-methylcarbamoyl)-2-isopropylphenyl)-1H-pyrazole3-carbonyl]amino] adamantane-2-carboxylic acid hydrochloride;SR 142948 hydrochloride
SMILES:	Cl.CN(CCCN(C(C1=CC=C(N2N=C(C(NC3(C4CC5CC3CC(C5)C4)C(=O)O)=O)C=C2C2=C(OC)C=CC=C2OC)C(C(C)C)=C1)=O)C)C
Formula:	C₃₉H₅₂ClN₅O₆
M.Wt:	722.313089370728
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM; antagonizes neurotensin-induced inositol monophosphate formation in HT 29 cells with IC50 of 3.9 nM, inhibits the turning behavior induced by neurotensin in mice, completely antagonizes neurotensin-evoked acetylcholine release in the rat striatum at 0.1 mg/kg; also blocks both hypothermia and analgesia induced by i.c.v. injection of neurotensin injection into the ventral tegmental area.

References:

References 1. Gully D, et al. J Pharmacol Exp Ther. 1997 Feb;280(2):802-12. 2. Betancur C, et al. Eur J Pharmacol. 1998 Feb 5;343(1):67-77. 3. Schaeffer P, et al. J Cardiovasc Pharmacol. 1998 Apr;31(4):545-50. View Related Products by Target Neurotensin Receptor

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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