| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22912 | SCH39166 | A potent, selective D1 dopamine receptor antagonist with Ki of 3.6 nM, >300-fold selectivity over D2 and 5-HT2 receptors. |
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| DC22910 | ABT-724 | A potent, selective dopamine D4 receptor agonist that activates human dopamine D4 receptors with EC50 of 12.4 nM, with no effect on dopamine D1, D2, D3, or D5 receptors. |
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| DC22909 | ABT-724 trihydrochloride | A potent, selective dopamine D4 receptor agonist that activates human dopamine D4 receptors with EC50 of 12.4 nM, with no effect on dopamine D1, D2, D3, or D5 receptors. |
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| DC22586 | AZD9496 maleate | A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68. |
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| DC20378 | FABP4 inhibitor 1 | A potent, selective FABP4 inhibitor with Ki of 30 nM.. |
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| DC11956 | CCG 258748 | A potent, selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 8 nM. |
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| DC22881 | GLP1-agonist-1 | A potent, selective GLP-1 agonist. |
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| DC20392 | GLUT4-IN-17 | A potent, selective glucose transporter 4 (GLUT4) inhibitor with IC450 of 10.8 uM, inhibits MM cell proliferation. |
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| DC22747 | AICP | A potent, selective GluN2C-selective NMDA receptor glycine site superagonist with EC50 of 1.7 nM at GluN1/2C. |
|
| DC23558 | (+)-NFPS | A potent, selective GlyT1 inhibitor that demonstrates >10-fold greater activity in in vitro functional glycine reuptake assay than racemic (±)-NFPS. |
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| DC20400 | HDAC1,2-IN-2 | A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively. |
|
| DC21373 | HDAC6 inhibitor NCT-14b | A potent, selective HDAC6 inhibitor with IC50 of 84 nM, with IC50s of >3.5 uM for the other HDAC isoforms.. |
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| DC21461 | PD-118057 | A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells. |
|
| DC22946 | ML-T531 Featured | ML-T531 is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM. |
|
| DC22990 | HIF1-IN-2 | A potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB. |
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| DC25054 | Gambogic amide | A potent, selective high affinity TrkA receptor agonist with Kd of 75 nM. |
|
| DC22966 | ABH hydrochloride Featured | A potent, selective human Arginase inhibitor with Ki of 0.25 uM (pH=7.5), 8.5 nM (pH=9.5) for type II arginase. |
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| DC22454 | IMPDH2-IN-5 | A potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with IC50 of 620 nM (inhibition of NO production). |
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| DC20345 | CLK inhibitor 2 | A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively. |
|
| DC11644 | Pitstop 1 | A potent, selective inhibitor of clathrin-independent endocytosis with IC50 of 18 uM (inhibition of clathrin TD-amphiphysin B/C complex formation). |
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| DC22897 | KRH-1636 | A potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5. |
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| DC22847 | L-870810 | A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties. |
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| DC23189 | CL-82198 Featured | CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression. |
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| DC22658 | Windorphen | A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM). |
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| DC22625 | Rolipram Featured | A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. |
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| DC23910 | Microcystin-LR | A potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM. |
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| DC22754 | SKA-111 | A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM. |
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| DC23551 | PF-05388169 | A potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM). |
|
| DC23550 | PF-05387252 | A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM). |
|
| DC22677 | (±)-U-50488 hydrochloride | A potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects. |
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