Wighteone is a compound isolated from the aerial parts of Genista ephedroides.

(E)-Flupentixol is a non-neuroleptic isomer of (Z)-flupenthixol.

Literature References: Exists as a glucoside in the rhizomes of Podophyllum peltatum L., Berberidaceae: von Wartburg et al.,Helv. Chim. Acta 40, 1331 (1957). Isoln from resin podophyllum: Hartwell, Detty, J. Am. Chem. Soc. 70, 2833 (1948); 72, 246 (1950);

Tricin is a natural flavonoid present in large amounts in rice bran. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7[1][2][3].

Novel agonist of insect olfactory receptors (ORs) acting at a binding site on the Orco subunit

Human flap endonuclease 1 (FEN1) inhibitor

Novel GluN2B subtype-selective NMDA antagonist

Novel capsid targeted inhibitor of HIV-1 replication

Novel cyclin dependent kinase inhibitor

Selective P2X4 antagonist

Competitive antagonist of the muscarinic acetylcholine receptors

Dopamine receptor antagonistReferences:Merck Index, 11th Ed., No. 1499Brunderlein, et al., J. Med. Chem., v. 18, 185 (1975)Humber, L.G., Bruderlein, F.T., Voith, K., "Neuroleptic agents of the benzocycloheptapyrido-soquinoline series: a hypothesis on thei

Dopamine receptor antagonist; less active enantiomer

A Histidine Decarboxylase Inhibitor

Selective GluN2A antagonist

A selective GSK3 inhibitor

CNS penetrant, selective M1 muscarinic receptor agonist

Moracin M is a phosphodiesterase-4 inhibitor isolated from Morus alba. Moracin M has anti-inflammatory activity. Moracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation. Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo.

Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2)

Antiparkinson agent, antagonizing NMDA receptor and promoting the synthesis of dopamine

Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) and potent inhibitor of adenosine deaminase

Odorant co-receptor (Orco) agonist

Novel Selective Allosteric Inhibitor of PHGDH and Serine Synthesis with Anti-tumor Activity, binding to site II

Soyasapogenol B is found in alfalfa. Soyasapogenol B is a constituent of soya bean saponin, Medicago, Astragalus, Trifolium species. Soyasapogenol B belongs to the family of Oleanane Triterpenes.

Monoamine oxidase inhibitor

Topical Nonsteroidal Anti-inflammatory

Potent and Selective Inhibitor of Glutathione S-Transferase Omega 1 (GSTO1)

A potent, allosteric dual Akt1, Akt2 inhibitor

P2X receptor antagonist, selective for P2X1, P2X3 and heteromeric P2X2/3 receptors

Multi-target-directed ligand for treatment of Alzheimer's disease

A lignan found in Castela emoryi, in Prunus mume or in Magnolia thailandica. This compound inhibits Helicobacter pylori motility in vitro

Selective agonist of dopamine D4 receptor

Ligand to the CBFß portion of the CBFß-SMMHC fusion protein, inhibiting its binding to the Runt domain of RUNX proteins, also being a modest potency inhibitor of the binding of wildtype CBFß to the RUNX1 Runt domain

A close structural analog of AH-7614 that lacks activity at FFA4 that can serve as negative control.

Less active enantiomer of baclofen.

Muscarinic receptor agonist

Novel Hepsin inhibitor, blocking prostate cancer bone metastasis

An dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals

a psychostimulant

CCK antagonist; selectively blocks CNS effects

Novel pathway-selective estrogen receptor (ER) inhibitor, inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity

Selective modulator of aryl hydrocarbon (Ah) receptor

Potent and selective PDE11 inhibitor

Novel Kv2.1 and Kv2.2 inhibitor

Selective inhibitor of α-synucleintranslational expression

A dual inhibitor of human secretory and cytosolic phospholipase A2 with anti-inflammatory activity.

Metabolite of physostigmine, displaying both anti-acetylcholinesterase and opiate agonist activities

Novel cell permeable, potent inhibitor of KDM5A, showing little to no activity against KDM5B, KDM6A, and KDM6B

Novel p18(INK4C) inhibitor

Prodrug of INDY, a novel potent ATP-competitive Dyrk1A inhibitor

Potent inhibitor of glutamate carboxypeptidase II and III

alpha-Adrenoceptor antagonist

An extract from the roots of Ligusticum porteri as an inhibitor of yeast-α-glucosidase (IC(50) 2.35 mM) in a noncompetitive fashion with a K(i) of 4.86 mM

pan Activator of Ras-related GTPases

Inhibitor of PCAF and p300 histone acetyltransferase activity

Antagonist of sigma receptors, also binding to the dopamine transporter and inhibiting dopamine uptake

Selective and potent CRTH2 antagonist

Calcium channel  blocker  and serotonin S2antagonist

Novel multi-targeted protein kinase inhibitor

Selective activator of alpha-synuclein translational expression

Anticholinergic agent, blocking end-plate ion conductance; Psychodysleptic agent

Polar adenosine receptor antagonist

An orally bioavailable pan-HER tyrosine kinase inhibitor. It inhibits human epidermal growth factor receptors

Orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases