| DC20387 |
Galiellalactone |
A small molecule, direct STAT3 inhibitor that inhibits the IL-6-induced SEAP expression with IC50 of 200-500 nM, blocks the binding of the activated STAT3 dimers to DNA. |
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| DC22841 |
NBD-11021 |
A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction. |
|
| DC23032 |
OX-1 |
A small molecule, specific Measles virus (MeV) entry inhibitor with IC50 of 55 uM. |
|
| DC20659 |
(2E,4E)-5-((1S,2S,4aR,6R,7S,8S,8aS)-7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)-2-methyl-N-(pyridin-3-yl-methyl)penta-2,4-dienamide
Featured
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A small-molecule compound that disrupts the Golgi apparatus by inhibiting the activation of ADP-ribosylation factor 1 (ARF1). |
|
| DC21203 |
KKL-40 |
A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture. |
|
| DC22787 |
EML-633 |
A small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 2 uM. |
|
| DC22788 |
EML-631 |
A small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 4 uM. |
|
| DC22937 |
STA-21 |
A small-molecule inhibitor of STAT3. |
|
| DC20558 |
STOML3 inhibitor OB-1
Featured
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OB-1 is a small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin; reversibly reduces the sensitiv |
|
| DC23027 |
INP-0400 |
A small-molecule inhibitor of type III secretion in Y. pseudotuberculosis, without affecting in vitro multiplication, causes a dose- and growth phase-dependent inhibition of C. trachomatis RB multiplication.. |
|
| DC22553 |
KIN-1408 |
A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus). |
|
| DC22799 |
ML-162
Featured
|
A small-molecule probe that selectively kills cells induced to express mutant RAS. |
|
| DC22800 |
ML-210
Featured
|
A small-molecule probe that selectively kills cells induced to express mutant RAS. |
|
| DC21029 |
Fusicoccin-A |
A small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1. |
|
| DC22854 |
PhiKan-083 |
A small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM. |
|
| DC23009 |
Gue-1654 |
A small-molecule that inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R in both recombinant and human primary cells. |
|
| DC20886 |
CGP-049090 |
A small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines. |
|
| DC22392 |
BRD-4592
Featured
|
BRD4592 is a small-molecule allosteric inhibitor that targets the tryptophan synthase (TrpAB) of Mycobacterium tuberculosis. TrpAB is a bifunctional enzyme composed of α and β subunits, which catalyzes the final steps of tryptophan biosynthesis. BRD4592 binds at the interface of the α and β subunits, disrupting the enzyme's function. |
|
| DC21831 |
Tepilamide fumarate |
A small-molecule, fumaric acid ester (FAE) compound that is a prodrug of methyl hydrogen fumarate (also known as monomethyl fumarate), for the treatment of relapsing-remitting multiple sclerosis and plaque psoriasis.. |
|
| DC21244 |
LMP-420 |
A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells. |
|
| DC26093 |
PH-064
Featured
|
A sodium channel inhibitor.. |
|
| DC24093 |
PF-915275
Featured
|
PF-915275 is a potent and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) (Ki ＜ 1 nM) with good preclinical pharmacokinetic properties.IC50 value: ＜ 1 nM (Ki)[2]Target: 11βHSD1in vitro: PF-915275 maintains potency in our cellular assay against human 11βHSD1 (HEK293, EC50 = 5 nM) and is selective against human 11βHSD2 (HEK293, 1.5% inhibition 10 μM). PF-915275 displays only weak affinity for the rodent choline transporter (Ki = 9.6 μM) and the hamster melatonin MT3 receptor (Ki = 9.6 μM) in the Cerep Bioprint screening panel. PF-915275 has good in vitro pharmacokinetic properties. In particular, PF-915275 is categorized as a low clearance compound (liver microsome assays) with high permeability (Caco2 assay). [2]in vivo: As a prelude to in vivo studies with PF-915275, the rat pharmacokinetic properties of this compound were determined. PF-915275 has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. [2] |
|
| DC22642 |
Sibiriline |
A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3. |
|
| DC21394 |
NOFD |
A specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM). |
|
| DC23022 |
PDZ1i
Featured
|
A specific inhibitor of MDA-9/Syntenin activity that inhibits MDA-9/Syntenin binding to EGFRvIII. |
|
| DC23589 |
CGP 37157
Featured
|
A specific inhibitor of mitochondrial Na(+)-Ca(2+) exchanger (mNCE) with IC50 of 1.5 uM in INS-1 cells. |
|
| DC22633 |
SB 203580 hydrochloride |
A specific p38 MAPK inhibitor with IC50 of 0.6 uM. |
|
| DC22835 |
SCH 350581 |
A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry.. |
|
| DC22830 |
SCH 350581 dihydrochloride |
A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry.. |
|
| DC20361 |
Difopein |
A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity. |
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