2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.

Aalgesic agent

Selective 5-HT(1A) agonist, significantly reducing depression symptoms and illness severity, improving sexual dysfunction

Potent activator of SHIP-1 inducing apoptosis of the cancer cell lines in vitro in both a time and dose dependant manner

Novel positive modulator of GABAA receptors

The first small molecule, S1P2 selective agonist reported

Novel specific Inhibitor of histone acetyltransferase

Inhibitor of the parasympathetic nervous system actions

Prodrug of indomethacin, nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD)

Anti-inflammatory and analgesic agent

An anticholinergic drug used in patients to reduce the side effects of antipsychotic treatment and a second-line drug for the treatment of Parkinson's disease

10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent.

Novel inhibitor of canonical Wnt signaling

Glucocorticosteroid; Antipsoriatic agent

Novel inhibitor of TRPM6, promoting mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis

Novel reversible inhibitor of autophagic flux, preventing Stx17 loading onto autophagosomes and blocking autophagosome-lysosome fusion without any effect on lysosomal properties or on endocytosis mediated degradation of EGF receptor

Calcium entry blocker, also being used as the precursor for radiolabelling emopamil

Inhibitor of of the metalloproteinase ADAM17; Inhibitor of the constitutive and the PMA-inducible CX3CL1 cleavage, blocking TACE as well as ADAM10

preQ1 is a precursor in the biosynthesis of queuosine, a bacterial nucleoside incorporated into tRNA by tRNA transglycosylase. preQ1 binds to an aptamer domain on tRNA that acts as a riboswitch to repress gene expression.

Novel Inhibitor of Bacterial Cytokinesis, inhibiting FtsZ

SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC50 of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC50 of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily.

Potent in vitro and in vivo inhibitor of fatty acid amide hydrolase (FAAH)

Selective inhibitor of NADPH oxidase activity in low micromolar concentrations, interfering neither with ROS detection nor with XOD or eNOS activities

Potent P2X7 antagonist blocking BzATP-evoked calcium influx

Highly selective D2 dopamine receptor antagonist

5-HT1A/1B serotonin receptor antagonist; β3-adrenoceptor antagonist

Novel inverse agonist of estrogen-related receptor γ (ERRγ)

TSPC is an inhibitor for GA perception by in vitro and in planta evaluations.

Selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel

A selective inhibitor of c-Met kinase

Inhibitor of the uPAR·uPA protein-protein interaction, blocking cancer cell invasion

Selective modulator of NMDA receptors, potentiates responses at GluN1/GluN2D

Highly specific allosteric activator for the tumor-specific isoform of human pyruvate kinase (M2 isoform)

Potent inhibitor of lipid droplet formation

ML-261 is a thienopyrrole-5-carboxamide that inhibits lipid droplet formation.

Potent, reversible, and ATP-competitive inhibitor of human Thymidylate kinase (TMPK)

Novel HCN4 CLP ligand, modulating channel function and completely abolishing the cAMP-induced shift in V1/2

Partial agonist in CXCR3-mediated chemotaxis, bound to CXCR3 in an allosteric fashion with the same efficacy as CXCL11

A phosphatidylinositol 3-kinase (PI3K) inhibitor

Novel orally active glycoprotein 130 (gp130) inhibitor

Novel Inhibitor of TNF-α

Novel, more stable resveratrol analog, protecting cardiac against mitochondrial damage following H/R, thereby suppressing injury

HAT Inhibitor II is a novel p300/CBP-selective histone acetyltransferase inhibitor.Histone Acetyltransferase Inhibitor II is a potent and cell permeable p300 inhibitor, with an IC50 of 5µM; Histone Acetyltransferase Inhibitor II can be used in cancer research.

Cell permeable cAMP analog, acting as a cardiac stimulant and inhibiting phosphodiesterase

An inducer of mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer

Novel Prolyl Hydroxylase Inhibitor Protects Against Cell Death After Hypoxia

Novel inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction

This compound belongs to the class of chemical entities known as triterpenoids. These are terpene molecules containing six isoprene units.

Inhibitor of ventricular tachyarrhythmias in intact mouse and rabbit ventricles by the suppression of SCaEs, independent of beta-blocking activity

Highly ASKA- (analog-sensitive kinase alleles) selective inhibitor

Novel inhibitor of the VP40 matrix protein

Novel FKBP12 inhibitor

Mitochondrial permeability transition pore (PTP) inhibitor

Standard for Ca2+ channel activativation

Clickable adenosine derivative, to capture newly polyadenylated transcripts, and next-generation sequencing reveals mRNA sequence motifs that are linked to polyadenylation

First-in-class nudix hydrolase family inhibitor, potently and selectively engaging and inhibiting the MTH1 protein in cells

Novel Nur77 modulator, inducing apoptosis of cancer cells by activating the Nur77-Bcl-2 apoptotic pathway

Novel Sirtuin-3 Inhibitor, Inhibiting Cell Survival and Proliferation, and Promoting Apoptosis of Head and Neck Cancer Cells

Isomer of KLH45 (AOB5741)

Novel selective inhibitor of primordial germ cell (PGC) development, targeting poly(A)-tail-independent noncanonical translation (PAINT)

Novel small molecule activator of PP2A (SMAP), negatively regulating c-myc in small cell lung cancer

Novel tubulin and HSP90 dual inhibitor, causing the destabilization of microtubules and degradation of HSP90 client proteins CRAF-1 and ERBB2, resulting in cell cycle arrest at the G2/M phase and apoptosis

The first highly potent and selective KDM5 inhibitor

Novel selective androgen receptor modulator, preventing body weight loss and sarcopenia in cancer cachexia models

Analog of GSK199 inhibiting PAD4

Dopamine and the D1 receptor agonist, stimulating phosphoinositide hydrolysis

Potent and Highly Selective Inhibitors of GSK3b

Anti-fibrotic agent, acting as an adiponectin receptor (AdipoR) agonist

Novel enhancer of tyrosine phosphorylation of EGFR via downstream signaling pathways

Direct iron chelator from β(2) subunit of ribonucleotide reductase

Novel chemical probe for heterochromatin formation and function, disrupting of heterochromatin-mediated transcriptional gene silencing

The first inorganic phosphate (Pi) targeted colorimetric and fluorescent probe to detect endogenous Pi in hemichannelclosed cells

Novel fluorescent tamoxifen derivative with unique SERM-like properties

Novel Fluorescent Probe of Blood-Brain Barrier Disruption in Animal Models

Fluorescent analogue of the dopaminergic neurotoxin MPP+

A highly selective off-on fluorescent probe for imaging thioredoxin reductase in living cells, displaying a green fluorescence off-on change induced by the TrxR-mediated disulfide cleavage and subsequent intramolecular cyclization to liberate the masked n

A fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures

Novel class of fluorescent probe, having good blood-brain barrier permeability, specificity to amyloid-β plaques, and "turn-on" bright far-red emission upon Aβ binding

Orally effective Fe chelator. being more active than desferrioxamine

A second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

An active opioid receptor antagonist

Potent and selective phospholipase D1inhibitor

Novel potent inhibitor of protein kinase CK2

Inducer of apoptosis

Novel blood brain barrier (BBB) penetrable two-photon imaging probe, labelling plaques and cerebral amyloid angiopathies (CAAs)

Potent MTH1 inhibitor; RAS​/RAC-​mediated membrane ruffling inhibitor

ATP competitive tyrosine kinase inhibitor

A stable, cell-permeable, non-competitive adenylyl cyclase inhibitor

Functional Agonist of the Apelin (APJ) Receptor

Selective, orally active 5-HT6 antagonist

SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD+ in mice.

Novel HIF-1α prolyl hydroxylase inhibitor

Novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recorded from pyramidal neurons

Novel inhibitor of the binding of Ral to its effector RALBP1, inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines

Novel inhibitor of Ral binding to its effector RALBP1 and inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines

Apoptosis inducer with selective antiproliferative activity.

Selective dopamine agonist

Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease

Novel activator of the transient receptor potential channel ML3 (TRPML3)

A GABA antagonist that acts via the benzodiazepine binding site of ag containing GABA receptors

Full 5-HT1A serotonin receptor agonist; more active enantiomer.

Gene-selective LXR modulator that mediates potent transcriptional activation of ABCA1 gene expression while exhibiting minimal effects on SREBP-1c

Potent TIR1 antagonist, blocking the formation of the TIR1-IAA-Aux/IAA complex and so inhibiting auxin-responsive gene expressionReferences:1) Smékalová V, Luptovčiak I, Komis G, Šamajová O, Ovečka M, Doskočilová A, Takáč T, Vadovič P, Novák O, Pechan T,

Novel inhibitor of human betaine-homocysteine S-methyltransferase (BHMT)References: 1) Strakova J, Gupta S, Kruger WD, Dilger RN, Tryon K, Li L, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and redu

Novel inhibitor of SIRT6, sensitizing pancreatic cancer cells to gemcitabineREFERENCES1) Damonte P, Sociali G, Parenti MD, Soncini D, Bauer I, Boero S, Grozio A, Holtey MV, Piacente F, Becherini P, Sanguineti R, Salis A, Damonte G, Cea M, Murone M, Poggi

Anti-inflammatory drug

Novel highly potent BET bromodomain inhibitor with more than 100-fold higher cellular potency than the corresponding monovalent antagonist JQ1

Novel ligand for the Methyl-lysine Binding Protein, 53BP1.

Novel non-toxic fluorescent probe to label the renal proximal tubules in zebrafishReference1) The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish; Chem Commun (Camb). 2015;51(2):395-8. doi: 10.1039/c4cc08075k. Epub 2014 Nov 1

Novel NMDA receptor antagonist

Potent and selective mGluR8-specific orthosteric agonist

A discontinued antiemetic drug used in post-operative care

α-Adrenergic blocker

Ecamsule.2Na is the Sodium salt form of Ecamsule. Ecamsule is an active ingredient of sunscreens that protects the skin from sunburn and erythema.

Polidocanol (Polyoxyethylene lauryl ether, Polyoxyethyleneglycol Dodecyl Ether, Brij30, Laureth-23, Varithena) is a sclerosant used for treating uncomplicated spider veins and reticular veins in the lower extremities.

Gadobutrol (Gadovist, Gadavist) is a non-ionic macrocyclic gadolinium-based contrast agent (GBCA) that is usedfor tissue contrast enhancement in magnetic resonance imaging (MRI).

Benzoin is a kind of alsamic resin isolated from the styracaceae family. Benzoin can be used as a colour additive used for marking plants.

1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism.

D-Cystine is the D-enantiomer of L-Cystine. D-Cystine inhibits L-aspartate-β-semialdehyde dehydrogenase (ASADH) from Escherichia coli.

Ethyl cinnamate is a fragrance ingredient used in many fragrance compounds. Ethyl cinnamate is a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues.

3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride.

(±)-Dihydroactinidiolide, an important aroma compound of black tea and tobacco, has been isolated from several plants. (±)-Dihydroactinidiolide can be formation from β-Carotene by the treatment of polyphenoloxidase, the lipoxygenase, and the xanthine oxid

Naphthoresorcinol (1,3-Dihydroxynaphthalene) is a fluorescent dye (λex=330 nm, λem=380 nm) that can react with the NPPD (a tracer) and concentrated HCl and develop a red color. Naphthoresorcinol could be used as a background electrolyte (BGE) to determine

Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant.

1-Nonadecanol is one of the compositions of supercritical carbon dioxide (SC-CO2) essential oil of Heracleum thomsonii. 1-Nonadecanol is also an important aroma compound in Neotinea ustulata.

(R)-(-)-1,2-Propanediol is a (R)-enantiomer of 1,2-Propanediol that produced from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes.

Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative can be used as a precursor to pharmaceuticals or fluorene-based dyes.

4α-Methylcholesterol is a Cholesterol derivative. 4α-Methylcholesterol can oxidize 3-hydroxy steroid, with the apparent Km of 12.6 μM.

N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (

Neophytadiene is a diterpene found in Turbinaria ornate, with anti-inflammatory antioxidant and cardioprotective properties.

DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [14C]

DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo.

N-Acetylpsychosine (C2 Galactosylceramide (d18:1/2:0)), α-galactosylated C2-Ceramide, has immunostimulatory activity. N-Acetylpsychosine can be a useful tool to investigate the mechanism of apoptosis and the immune reponses induced by dendritic cells (DCs

β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases.

β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases.

SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM).

Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3).

GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2.

(-)-Anomalin ((-)-Praeruptorin B) is a coumarin derivative isolated from the root of S. resinosum.

Naph-EA-mal (Thiol-green 1) is a rapid detect and ultrafast turn-on thiol fluorescence probe for protein labeling and bioimaging. Naph-EA-mal (Thiol-green 1) can be used to detect thiols in living cells, label the protein thiols, quantify the concentration of total thiols in cell lysate, and determine the reversible protein thiols oxidation in fixed cells. Ex: 488 nM; Em: 540 nM.