DC24136 |
Amitifadine hydrochloride |
A triple monoamine reuptake inhibitor that inhibits the reuptake of [3H]serotonin, [3H]norepinephrine, and [3H]dopamine in HEK 293 cells expressing the corresponding human recombinant transporters (IC50 values of 12, 23, and 96 nM, respectively). |
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DC22736 |
Amitifadine |
A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively. |
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DC21185 |
Cucurbitacin I |
A triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM. |
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DC23062 |
RAMX3 |
A tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM. |
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DC22473 |
Loxapine |
A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.. |
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DC22477 |
Loxapine succinate |
A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.. |
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DC8197 |
Tyrosine kinase inhibitor
Featured
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A Tyrosine kinase inhibitor. |
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DC22811 |
TX-1123 |
A tyrphostin AG17 analog that exihibits potent Src-K inhibitory activity with IC50 of 2.2 uM. |
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DC24189 |
Closantel sodium |
A veterinary anthelmintic with known proton ionophore activities. |
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DC24190 |
Closantel |
A veterinary anthelmintic with known proton ionophore activities. |
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DC23096 |
BCX-4430 |
A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator. |
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DC25095 |
BCX4430 freebase |
A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator. |
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DC22579 |
Retaspimycin hydrochloride |
A water-soluble derivative of 17-AAG and HSP90 inhibitor. |
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DC22983 |
Minnelide |
A water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival. |
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DC22868 |
Propofol |
A widely used general anesthetic to induce and maintain anesthesia. |
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DC23233 |
AH 6809
Featured
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A xanthone derivative that fuctions as an EP and DP receptor antagonist. |
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DC22878 |
LB-205 |
A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo. |
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DC12702 |
A1874
Featured
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A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells). |
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DC7044 |
A-205804 |
A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively. |
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DC9574 |
A-317491 (sodium salt hydrate)
Featured
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A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. |
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DC23659 |
A-357300 |
A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM. |
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DC12659 |
A-381393
Featured
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A-381393 is a potent and selective agonist of the dopamine D4 receptor. |
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DC20610 |
A-395N |
A-395N is the negative control compound of A-395, which is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM.. |
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DC22277 |
A-420983
Featured
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A-420983 is a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. |
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DC20611 |
A4250
Featured
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A4250 (A-4250, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH.. |
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DC8406 |
A-438079 HCl
Featured
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A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. |
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DC20612 |
A-68930 hydrochloride |
A-68930 is a potent, specific, orally bioavailable agonist of the D1 Dopamine receptor with EC50 of 2.5 nM. |
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DC11372 |
A-779
Featured
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A-779 is a peptide antagonist of the Mas receptor, also known as the angiotensin (1-7) (Ang (1-7)) receptor (IC50 = 0.3 nM in a radioligand binding assay). |
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DC7785 |
A-790742 |
A-790742 is a potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor, with 50% effective concentrations ranging from 2 to 7 nM against wild-type HIV-1. |
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DC20613 |
A-800141 |
A-800141 is a potent, highly specific, orally bioavailable MetAP2 inhibitor with IC50 of 12 nM, shows no inhibition for MetAP1 (IC50>30 uM). |
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