MAT2A inhibitor 4 is an inhibitor of the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A). MAT2A inhibitor 4 can be used for the research of cancer.

STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC50 of 7 nM.

Inaxaplin is an apolipoprotein L1 (APOL1) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease.

IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC50 value of 3.9 nM.

GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.

Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease.

(−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally active terpene with antitumour activity. (−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats.

Nizaracianine (ZW800-1) is an zwitterionic near-infrared (NIR) fluorescent dye, exhibits low background (emission ≈ 800 nm). Nizaracianine is an imaging agent in vivo.

FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect.

Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses.

Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.

Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity.

Piperitone is as a powerful repellent and antiappetent agent. Piperitone is very toxic to Cymbopogon schoenanthus (C. schoenanthus) adults, newly laid eggs and to neonate larvae. Insecticidal activity.

Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.

PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 µM; Ki=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses. From WO2021007491A1 compound L-1.

Simufilam (PTI-125) (hydrochloride) is a low toxicity, orally active filamin A (FLNA) activator. Simufilam (hydrochloride) preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam (hydrochloride) can be used for the research of Alzheimer's disease.

IONIS-DNM2-2.5Rx (DYM101) is an antisense agent targeting dynamin 2. IONIS-DNM2-2.5Rx has the potential for the research of centronuclear myopathy (CNM).

SRP-5051 is a next-generation antisense oligonucleotide of peptide phosphorodiamidate morpholino oligomer (PPMO). SRP-5051 targeting exon 51 skipping in Duchenne muscular dystrophy (DMD).

Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion.

Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide. Eteplirsen can be used for Duchenne muscular dystrophy research.

Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen can be used for the research of Duchenne muscular dystrophy (DMD).

Viltolarsen (NS-065/NCNP-01), a phosphorodiamidate morpholino antisense oligonucleotide, targets the splicing of exon 53 in the dystrophin gene. Viltolarsen can be used for the research of the Duchenne muscular dystrophy (DMD).

Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS).

Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis.

Golodirsen (SRP-4053) is a phosphorodiamidate morpholino oligomer (PMO) that specifically targets exon 53 of dystrophin pre-mRNA. Golodirsen can be used for the research of Duchenne muscular dystrophy (DMD).

Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria.

Suvodirsen (WVE-210201) is a oligonucleotide. Suvodirsen has the potential for study Duchenne muscular dystrophy (DMD).

Lexanersen (WVE-120102) is an antisense oligonucleotide used for the study of Huntington's disease.

IONIS-MAPTRx (BIIB080) is the first Tau-lowering antisense oligonucleotide (ASO). IONIS-MAPTRx has the potential for the research of Alzheimer Disease.

ARO-AAT is a second-generation RNAi drug. ARO-AAT consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade AAT mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes.

Defibrotide sodium is a complex mixture of single stranded polydeoxyribonucleotides. Defibrotide sodium has liver protection, anti-inflammatory, antithrombotic, profibrinolytic, and anti-ischemic properties. Defibrotide sodium can be used for sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) research.

Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1).

Vutrisiran (ALN-TTRsc02) is a liver-directed, investigational, small interfering ribonucleic acid (siRNA) agent. Vutrisiran can be used for transthyretin (TTR)-mediated amyloidosis research.

Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research.

Revusiran (ALN-TTRSC) is a 1st-generation short interfering RNA, which directed against transthyretin (TTR) mRNA. Revusiran can be used for transthyretin (TTR)-mediated amyloidosis research.

Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy.

Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma.

LOX-IN-3 Dihydrochloride is an orally active and selective lysyl oxidase (LOX) inhibitor.

Ammonium chloride is an inorganic compound and can be used for establishing the rat model of renal calcium oxalate calculus.

7,12-Dimethylbenz[a]anthracene (DMBA) is an immunosuppressor as well as a potent organ-specific carcinogen.

Ficusonolide has significant antidiabetic activity with a possible mechanism of interaction with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.

BRD4 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs.

PKM2-IN-3 is a inhibitor of PKM2 kinase with IC50 value of 4.1μM. PKM2-IN-3 exhibits an anti-neuroinflammatory effect by inhibiting PKM2-mediated glycolysis and NLRP3 activation.

1,4,7-Triazonane (1,4,7-Triazacyclononane), an intermediate in the synthesis of 1,4,7-trifunctionalized derivatives, is a possible reagent for compleximetric titrations with high cation-binding selectivity.

3-Phenylpropyl isothiocyanate has a stronger inhibitory effect on N-nitrosomethyl-benzylamine (NMBA) tumorigenesis. 3-Phenylpropyl isothiocyanate has chemopreventive effects.

CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity.

(±)13-HpODE (13-hydroperoxylinoleic acid) is a racemic mixture of hydroperoxides, which is produced by the oxidation of linoleic acid by lipoxygenase.

6,7-Dimethyl-8-ribityllumazine is a direct biosynthetic precursor of Riboflavin. 6,7-Dimethyl-8-ribityllumazine is a noncovalently bound fluorophore of Lumazine protein (LumP), which is a fluorescent accessory protein.

(Z)-PUGNAc is a potent O-GlcNAcase inhibitor. (Z)-PUGNAc is a vastly more potent inhibitor of O-GlcNAcase than the E form.

(S)-ErSO is the dextrorotatory enantiomer of ErSO. (S)-ErSO is inactive in MCF-7 cells (from patent WO2020009958A1, compound (s)-105).

Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC50s of 39 nM and 27 nM, respectively.

p-SCN-Bn-DOTA is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunotherapy of tumor.

ANAT inhibitor-2 is a ANAT inhibitor for canavan disease, with an IC50 value of 20 μM.

CR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation.

ProSeAM is a chemical tool for methylome analysis.

GT-1 (LCB10-0200), a siderophore-linked cephalosporin, is effective against clinical isolates of P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.

MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.

Spectinamide-1599 is a combination partner for anti-tuberculosis therapy.

HAV 3C proteinase-IN-1 is a inhibitor of Hepatitis A virus 3C proteinase.

HoPan inhibits phosphopantotenoylcysteine synthetase activity.

4-Maleimidosalicylic acid is a polar maleimide, and does not suppress IL-2 production in JURKAT T cells.

CXCL12 ligand 1 is the first ligand of the sY12-binding pocket on chemokine CXCL12.

Se-DMC attenuates complete Freund’s adjuvant (CFA)-induced inflammatory response, nociception, and neurobehavioral deficits in mice.

DNDI-6148 acts principally through the inhibition of Leishmania cleavage and polyadenylation specificity factor (CPSF3) endonuclease for the treatment of visceral leishmaniasis (VL).

c-ABL-IN-1 is a novel selective c-Abl inhibitor that prevents neurodegeneration in parkinson’s disease.

ARN19689 is found to inhibit human NAAA in the low nanomolar range (IC50 = 0.042 μM) with a non-covalent mechanism of action.

Br-DAPI is a water-soluble, cell-permeable, DNA-binding photosensitizer.

Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice.

Cavα2δ-IN-1 shows high selectivity for voltage-gated calcium channels Cavα2δ-1 (Ki 6 nM) versus Cavα2δ-2 (Ki ＞ 10000 nM).

BTNPO is a unimolecular two-photon fluorescent probe.

FTO-IN-2 is a FTO inhibitor that impairs self-renewal in glioblastoma stem cells.

FTO-IN-3 is a FTO inhibitor that impair self-renewal in glioblastoma stem cells.

Kbz probe 1 serves as a versatile probe for interrogating histone benzoylation and interactions in living cells.

Carboxylesterase-IN-1, a novel pesticide, exhibits inhibitory action on carboxylesterase at 50 μg/mL similar to the known inhibitor triphenyl phosphate.

DEPTOR-IN-1 is a novel putative DEPTOR inhibitor with a Kd value of 9.3 μM.

RdRP-IN-3 is a promising anti-influenza drug candidate by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).

Nln activator 1 is a first-in-class peptidomimetic neurolysin activator possessing enhanced brain penetration and stability.

MCA17-1 shows stronger bioactivity than the positive control obeticholic acid (OCA) against liver fibrosis.

BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC50 value of 9.9 nM.

Plasma kallikrein-IN-1 is a PKK inhibitor with an IC50 value of 0.5 nM.

α/β-Hydrolase-IN-1 exhibits the best-in-class MICs of 50 μM (25 μg/mL) and 16 μM (8.4 μg/mL) against M. smegmatis and M. tuberculosis H37Ra, respectively.

BG dimer is a molecular dimer organic luminogen with aggregation-induced emission.

PSMA–DA1 may be a useful PSMA-targeting radiotheranostic agent.

Betulinic acid derivative-1 exhibits distinguished activities on inhibiting osteoclast (OC) differentiation with an IC50 value of 1.86 μM.

Salpyran is a Cu(II) selective chelator with therapeutic potential.

Eroonazole is a new small molecule disrupter of endoplasmic reticulum structure.

FgGpmk1-IN-1 is a novel fusarium graminearum mitogen-activated protein kinase (FgGpmk1) inhibitor with an EC50 value of 3.46 μg/mL.

ANAT inhibitor-1 is a human aspartate N-acetyltransferase (ANAT) inhibitor for canavan disease.

Anticancer agent 13 is an anticancer agent from dicarboxylic acids and amines.

N-Octylmaleimide is an alkylmaleimide, which can inhibit rat liver glucose 6-phosphatase.

ThrRS-IN-2 is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 value of 56.5 ± 3.5 μM.

α-Santalene is a precursor of Sandalwood Oil.

CuATSP, a potent inhibitor of ferroptotic cell death, is almost 20-fold more potent than CuATSM.

Diphenyl Phosphate inhibits growth and energy metabolism of zebrafish in a sex-specific manner.

Lynamicin B is a potential pesticide by acting as a lepidoptera-exclusive chitinase inhibitor with a Ki value of 8.76 μM.

(6R,7S)-Cefminox sodium heptahydrate is an isomer of Cefminox sodium heptahydrate. Cefminox sodium heptahydrate is a β-lactam cephalosporin antibiotic, which exhibits a broad spectrum of antibacterial activity.

UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.

TTK inhibitor 3 is a potent and selective TTK (an essential spindle assembly checkpoint enzyme) inhibitor with an IC50 value of 3.0 nM.

TrxR-IN-2, a potential thioredoxin reductase (TrxR) inhibitor, represents a promising candidate drug for the chemotherapy of drug-resistant hepatocellular carcinoma.

SBP-3264 is a valuable chemical probe for understanding the roles of STK3 and STK4 in acute myeloid leukemia (AML).

PPO-IN-1 is a potent protoporphyrinogen IX oxidase (PPO) inhibitor with a Ki value of 2.5 nM.

NI-Pano (CH-03) is a novel hypoxia-activated KDAC inhibitor. NI-Pano (CH-03) is reduced in an O2-dependent manner to release panobinostat.

HBTP-H2S (chloride) is a NIR fluorescent probe for in situ bioimaging of endogenous H2S in rice roots under Al 3+ and flooding stresses.

eeAChE-IN-2 is a potent eeAChE inhibitor with an IC50 value of 2 nM.

eeAChE-IN-1 is a potent eeAChE inhibitor with an IC50 value of 23 nM.

Anticancer agent 17 displays potent anticancer activities against HeLa and A2780 cells with IC50 values of 0.19 μM and 0.09 μM, respectively.

Anti-TSWV agent 1 exhibits excellent inactivation activity against tomato spotted wilt virus (TSWV), with an EC50 value of 144 μg/mL.

NCATS- SM4487 is a highly selective unique dihydropyrimidine inhibitor against GALK1, with an IC50 value of 0.05 μM.

CASK-IN-1 is a highly potent and selective CASK inhibitor with a Kd value of 0.022 μM.

GT-055 (LCB18-055) is a novel broad-spectrum β-lactamase inhibitor.

NCATS-SM4487 is a highly selective unique dihydropyrimidine inhibitor against GALK1, with an IC50 value of 0.05 μM.

RMG8-8 shows the excellent efficacy against C. neoformans (1.56 μg/mL).

RH-EDA is a rhodamine-based turn-on fluorescent probe for detecting hydroxyl radicals in living systems.

Nitro-coronene can be used to prepare near-infrared light-triggered lysosome-targetable carbon dots for photothermal therapy of cancer.

LtIA-F, a novel fluorescent analogue of LtIA, provides a wealth of pharmacological tools to explore the structure–function relationship, distribution, and ligand binding domain of the α3β2 nAChR subtype.

Galectin-8-IN-1 is a selective ligand for the galectin-8 N-terminal domain (galectin-8N), with a Kd of 48 μM and 15-fold selectivity over galectin-3 and even better selectivity over the other mammalian galectins.

Epyrifenacil is a newly developed herbicide.

DN-F01 has a strong inhibitory calcium-dependent effect on cardiac myofibrillar ATPase activity with an IC50 value of 11 ± 4 nmol/L.

Antitumor agent-29 is a novel hepatocyte-targeting antitumor prodrug, which exhibits good antitumor activity and low toxic side effects.

Anti-inflammatory agent 6 blocks the phosphorylation of I kappa b kinase α/β (IKKα/β), IκBα, and nuclear factor kB p65 (NF-κB p65) which is a key controller of inflammation, thereby showing anti-inflammatory potential.

Antidepressant agent 2 exerts pronounced antidepressant activity (MED 0.1 mg/kg).

Anticancer agent 12 is unexpectedly devoids of hepatotoxicity while maintaining cytotoxic activity in malignant cells.

Transketolase-IN-1 is a promising herbicide candidate for weed control in wheat and maize fields targeting transketolase.

Quorum Sensing-IN-1 is a small-molecule quorum sensing inhibitor.

MtDTBS-IN-1 is a particularly potent binder (KD = 57 nM) and inhibitor (Ki = 5 μM) of MtDTBS.

MEIS-IN-2 is a myeloid ecotropic viral integration site 1 (MEIS1) inhibitor.

Kdn probe-1 is a fluorescent Kdn probe and reveals the localization of AfS in vesicles at the cell surface.

hTrkA-IN-2 is a selective hTrkA allosteric inhibitor with an IC50 value of 3.9 nM.

FTO-IN-5 is a potent and selective inhibitor of fat mass obesity-associated protein (FTO).

FTO-IN-4 is a potent and selective inhibitor of fat mass obesity-associated protein (FTO).

Cyclopropenone probe 1 can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site.

APJ receptor agonist 3 is a potent and orally active APJ receptor agonist with an EC50 value of 0.027 nM.

Antiviral agent 7 is a peptide-based coating that can kill viruses.

Anti-ToCV agent 1 can be used as a potential anti-ToCV drug.

β-N-Acetyl-D-hexosaminidase-IN-1 is a novel β-N-acetyl-d-hexosaminidase inhibitor with a Ki value of 3.72 μM.

MEIS-IN-1 is a potent myeloid ecotropic viral integration site (MEIS) inhibitor to induce murine and human hematopoietic stem-cell expansion.

BAY-091 is a novel potent and highly selective inhibitor of the kinase PIP4K2A.

Piceid 6″-O-azelaic acid ester shows high intracellular tyrosinase inhibitory and depigmentating activities.

Antiviral agent 6 shows excellent anti-TSWV activity in vivo, and the EC50 value is 188 mg/L.

Ultrashort α,β-Peptide is found to be able to stabilize colloidal gold nanoparticles in physiological media over 3 months.

gTPA2-OMe is a potential hole transport layer candidate for perovskite solar cells (PSCs).

TSWV-IN-1 is a potential anti-TSWV agent that targets TSWV N.

ERGi-USU-6 (mesylate) is an ERGi-USU-6 salt derivative that is a new selective inhibitor of ERG positive prostate cancer ( IC50 = 0.089 μM).

PDGFP 1 is a promising probe for simultaneously differentiating glioma boundary and grades.

MEIS-IN-3 is a potent myeloid ecotropic viral integration site (MEIS) inhibitor.

Anticancer agent 16 exhibits good cytotoxic activity against HCT-116, NCI-H460, and SKOV3 cell lines with IC50 8.55 μΜ, 5.41 μΜ, and 6.4 μΜ, respectively.

PREP inhibitor-1 is a highly potent prolyl oligopeptidase (PREP) inhibitor (IC50 < 1 nM).

TIM-3-IN-1 represents useful tool to further study the biology of TIM-3 immune modulation in cancer.

Anticancer agent 14 is a lead compound (IC50: 0.20 to 0.65 μM) that induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.

Peptide 78, a chemotactic cytokine, a 78 amino acid protein member of the IL-8 or C-X-C chemokine supergene family. ENA-78 plays an important role in the elicitation of predominantly neutrophils (PMNs) into the joints of rheumatoid arthritis (RA).

ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment.

BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes.

D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP can block karyokinesis and reduce cyst production.

Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA), the R enantiomer of (Rac)-Idroxioleic acid, is an orally active fatty acid that modulates the lipid composition and structure of the membranes. Idroxioleic acid has antitumor activities.

4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer.

R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs.

Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions.

Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways.

SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM.

SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.

ABT-384 is a selective 11-β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor. ABT-384 blocks regeneration of active cortisol. ABT-384 exhibits high affinity against rodent, monkey, and human HSD-1 whit a Ki of 0.1-2.7 nM.

Oxythiamin diphosphate ammonium is a potent transketolase (TK) inhibitor.

Nurr1 agonist 1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1.

2-Acetamidofluorene (2-AAF, 2-Acetaminofluorene, N-2-Fluorenylacetamide, N-Acetyl-2-aminofluorene) is a carcinogenic and mutagenic compound.

L(+)-Monosodium glutamate monohydrate (MSG monohydrate, L-Glutamic acid monosodium salt monohydrate, Monosodium L-glutamate monohydrate, Monosodium L-glutamate monohydrate) is a widespread nutritional additive and flavoring agent. L(+)-Monosodium glutamate monohydrate can lead to oxidative stress-mediated DNA damage and apoptosis.

N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN, OH-BBN) is a model compound that induces high-grade, invasive tumors in the urinary bladder.

Colesevelam Hydrochloride is an orally administered, non-absorbable, polymeric, bile-acid-binding agent with a higher affinity for glycocholic acid in vitro.

Zinc acetate induces the expression of enterocyte metallothionein.

Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.

Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=375 μM) in a competitive fashion with respect to cyclic GMP and the Ki value is 300 μM.

Aβ Fibrillization modulator 1 stabilizes Aβ monomers.

8-Methylsulfinyloctyl isothiocyanate, an isothiocyanate, has antimicrobial activity and remarkable inhibitory activity against plant growth. 8-Methylsulfinyloctyl isothiocyanate impair COX-2 mediated inflammatory responses in LPS stimulated raw macrophages.

LysoTracker Red (LysoTracker Red DND-99) is a paraformaldehyde fixable probe that concentrates into acidic compartments of cells and tissues. LysoTracker Red is an indicator of cell death in a manner similar to other standard assays (Annexin, terminal dUTP nick end labeling, Nile blue sulfate, neutral red, and acridine orange). LysoTracker Red is a marker for late endosomes and lysosomes.

BCECF-AM is a cell membrane permeable compound widely used as a fluorescent indicator for intracellular pH.

Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, non-toxic to neuronal cells, and selectivity inhibits the fibrilization of tau over Aβ42.

cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc) provides an avenue for developing a nonhormonal male contraceptive by blocking of GRTH/DDX25 phosphorylation.

Mulberrofuran Q inhibits the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products).

Olivil monoacetate is found in Gymnosporia varialilis Loes.

7Z-Trifostigmanoside I is found in Polygala hongkongensis Hemsl.

Moscatin inhibits AA-induced platelet aggregation in a concentration-dependent manner with IC50 values 37.2 μM .

Ilexsaponin B3 has significant hypocholesterolemic activity.

Boeravinone A is found in Boerhavia diffusa L.

Schisanwilsonin B is a lignan from the fruits of Schisandra wilsoniana.

27-O-Acetyl-withaferin A is found in Withania aristata.

OJV-VI is found in ophiopogonis.

25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside shows inhibitory activity of neutrophil respiratory burst stimulated by PMA(phorbol myristate acetate).

Peucedanocoumarin II can induce rice resistance to blast disease.

3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone displays cytotoxicity of 1.32, 3.92 and 5.22 μm against the human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells.

Quebecol is a nutraceutical agent against periodontitis.

2,3-Bis(3-indolylmethyl)indole significantly suppresses RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner.

Eugenol rutinoside is found in dendropanax dentiger.

Rutaretin is found in Atalantia racemosa.

Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

Monnieriside G is found in Cnidium monnieri fruits.

Isohericerin is an isoindolinone natural product.

Rotundatin is useful in inhibition of the aggregation of platelets induced by arachidonic acid and collagen.

7,22,25-Stigmastatrienol is one of sterols of Berrettina pumpkin seed oil.

Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells.

Hemiphroside B is found in Lagotis integra.