Dansylcadaverine (Monodansyl cadaverine, MDC) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands.

CETP-IN-4 is a cholesteryl ester transfer protein (CETP) inhibitor.

DNPH1i (N6-benzyladenosine,BAPR) is a competitive inhibitor of adenosine deaminase(ADA) from L-1210 cells in axenic culture as well as a potent antiproliferative agent in vitro and in vivo.

Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (Kd=81.2 nM) and adiponectin receptor 1 (AdipoR1; Kd=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP).

CD73-IN-5 is a potent and selective non-nucleotide small molecule inhibitor of CD73 (IC50 = 19 nM).

EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently.

BC-LI-0186 is a selective blocker of Leucyl-tRNA synthetase (LRS, LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (LRS-RagD interaction) (IC50 = 46.11 nM) by competing against RagD for LRS VC domain binding (KD = 42.1 nM), thereby inhibiting lysosomal localization of LRS and mTORC1 activity. It also effectively suppresses the activity of cancer-associated mTOR mutants and the growth of rapamycin-resistant cancer cells.

BM213, a potent and selective agonist for C5aR1, shows antitumor activity in a mouse model of mammary carcinoma.

Borofalan (10B) (SPM-011; Steboronine), a Ionising radiation emitter, can be used to treat the head and neck cancer.

Poly-L-lysine (hydrochloride) is a water-soluble synthetic polypeptide.

D-Fructose-13C6 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.

DL-Tyrosine-13C9,15N is the 13C- and 15N-labeled DL-Tyrosine. DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine).

13C-urea is the 13C labelled urea. The 13C-urea breath test (13C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection.

Gold(III) chloride trihydrate is a reducing agent. Gold(III) chloride trihydrate Can be used for the chemical synthesis of gold nanoparticles (NP).

LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model.

Curvulinic acid is a phytotoxic compound, has herbicidal activity.

Cyclopentenyl uracil, a non-cytotoxic inhibitor of uridine kinase, effectively blocks the salvage of circulating uridine by host and tumor tissues in the intact mouse.

3'-Amino-3'-deoxyadenosine is an antitumor agent extracted from Helminthosporium.

Hydroaurantiogliocladin is a quinol. Hydroaurantiogliocladin can be used as substrate for the quinol-cytochrome c oxidoreductase activity (beef heart enzyme).

3,4-Di-O-acetyl-L-fucal is the reactant for synthesis antibiotics (extracted from patent WO1999026956A1).

β-Phellandrene is obtained from Canada-balsam oil by fractional distillation. β-Phellandrene can be used to essential oil additives.

Ethylenediaminetetraacetic acid (EDTA) disodium dihydrate is a chelating agent used as a protease inhibitor and metal ion scavenger. Ethylenediaminetetraacetic acid disodium dihydrate is used extensively during protein purification. Ethylenediaminetetraacetic acid disodium dihydrate has been shown to be a noneffective molecule on cellulase activity. Ethylenediaminetetraacetic acid disodium dihydrate binds to metals including calcium and facilitates their excretion.

Fosdenopterin (Precursor Z) hydrobromide dehydrate is a synthetic cyclic pyranopterin monophosphate (cPMP). Fosdenopterin hydrobromide dihydrate can be used for the research of molybdenum cofactor deficiency (MoCD) type A.

3-Methylchromone is an active compound which can be used in the prevention and research of anginose attacks of coronary origin.

Tiliquinol (NSC 130828) is a non-absorbed anti-amoebic luminal agent. Tiliquinol is used in combination with tibroquinol. Tiliquinol can be used for the research of amebic liver abscess.

Phenylethynylcarbinol carbamate is a hypnotic agent.

Benzylthiouracil is an active pharmaceutical ingredient against hyperthyroidism.

7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs.

Lachnone A is a chromone derivative isolated from the filamentous fungus Lachnum sp. BCC 2424.

Iophenoxic acid is a systemic blood marker for assessment of bait acceptance by stoats (Mustela erminea) and weasels (Mustela nivalis).

Falimint is an antipyretic and analgesic compound.

Antifungal agent 21 is a promising candidate in the development of new agrochemical antifungal agents.

Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore.

2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria.

LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases.

HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant.

Magnesium citrate is a magnesium salt form that provides efficient penetration into brain and muscle tissue. Magnesium citrate increases pain threshold and reduces TLR4 concentration in the brain. Orally active.

4-Methyl-6-phenyl-2H-pyranone can be used for the synthesis of N-hydroxypyridone derivatives, which can protect astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality.

7-Amino-4-methylcoumarin-3-acetic acid is a fluorescent protein labelling agent. 7-Amino-4-methylcoumarin-3-acetic acid emits in the blue region (440-460 nm) on activation with UV light (350 nm).

α-Pyridoin is a unique enediol antioxidant.

(2S,5S)-Censavudine ((2S,5S)-OBP-601) is the (2S,5S)-enantiomer of Censavudine. Censavudine, a nucleoside reverse transcriptase inhibitor, is a potent HIV inhibitor.

Radicinin, a fungal phytotoxin, is a target-specific bioherbicide for Invasive Buffelgrass (Cenchrus ciliaris) control.

4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-nitrophenol 4-Nitrophenyl β-D-glucuronide is a chromogenic compound and is the chromogenic substrate for β-glucuronidase.

6-Methoxy-N-ethylquinoliniumiodide is a chloride-specific chromophore.

N6,2′-O-Dimethyladenosine, a substrate of fat mass and obesity-associated gene (FTO), is a reversible modification widely occurred on varied RNA molecules. N6,2′-O-Dimethyladenosine can regulate obesity.

Zinc Gluconate has the potential for the research of common cold, cancer, and a nutrition supplement as a food additive.

Methyl palmitate-13C16 is the 13C labeled Methyl palmitate. Methyl palmitate, an acaricidal compound occurring in green walnut husks, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects.

Myxin is a di-N-oxide phenazine produced by Lysobacter antibioticus OH13. Myxin is toxic to many microorganisms and tumor cells.

SulfoxFluor is a novel deoxyfluorination reagent. SulfoxFluor is shelf-stable, easy-to-handle, fluorine-economical, and highly selective.

Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies.

Salinazid is an antituberculous compound.

Glymidine sodium is an oral active antidiabetic. Glymidine sodium is the inhibitor of hepatic lipolysis. Glymidine sodium inhibits the glucose formation and supresses the elevated pyruvate oxidation which results from the inhibition of endogenous lipid mobilization.

Glymidine (Glidiazine) is a hypoglycaemic agent. Glymidine is a lipid soluble sulphapyrimidine derivative. Glymidine appears to stimulate insulin release from pancreas. Glymidine is a possible alternative to the sulphonylureas and biguanides for the research of diabetes mellitus.

Banksialactone A is the metabolite of an Australian fungus, Aspergillus banksianus.

Pentifylline is a vasodilator. Pentifylline inhibits platelet aggregation and thromboxane A2 synthesis, decrease the release of free radicals. Pentifylline has the potential for the research of acute ischaemic stroke.

Lalistat 2 is a specific inhibitor of lysosomal acid lipase (LAL) with no effect on other forms of lipase.

PrDiAzK is a bifunctional amino acid. PrDiAzK can be site-selectively incorporated into proteins in both bacterial and mammalian cell culture. PrDiAzK can be used for proteome-wide incorporation via stochastic orthogonal recoding of translation (SORT).

Cholera autoinducer 1 is Vibrio cholerae autoinducer (S)-3-hydroxytridecan-4-one. Cholera autoinducer 1 influences chemotaxis in C. elegans.

Oosporein is a red crystalline metabolite produced by a toxin-producing strain of Chaetomium trilaterale. Chaetomium trilaterale is isolated from moldy Peanuts. Oosporein inhibits plant growth and produces phytotoxic effects.

BTA-1 is an uncharged derivative of thioflavin-T. BTA-1 has high affinity for Aβ fibrils and shows very good brain entry and clearance.

FTO-IN-6 is a selective fat mass and obesity associated protein (FTO) inhibitor.

2-Methoxyphenyl benzoate is an active compound.

Sulfo-NHS-Biotin (sodium) stongly label single SDS-2ME soluble cuticular protein.

Clonostachydiol is an anthelmintic macrodiolide from the fungus Clonostachys cylindrospora (strain FH-A 6607).

Isoamyl 4-(dimethylamino)benzoate can be used for the synthesis of inclusion complex (isoamyl4-(Dimethylamino)benzoate with sulfobutylether-β-cyclodextrin).

Palitantin ((±)-Palitantin), a metabolite of Penicillium frequentans on Leishmania brasiliensis, has antiprotozoal effect against Leishmania brasiliensis.

Pentetic acid is a compound used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater.

Tetradecyl sulfate sodium, a detergent sclerosant, is widely used agent for esophageal varices and varicose veins.

Sodium tetradecyl sulfate (Tergitol 4) is a sclerosing agent used for the research of varicose veins.

MR 409 is a selected growth hormone-releasing hormone (GHRH) agonist. MR 409 has remarkable neuroprotective effects through enhancing endogenous neurogenesis in cerebral ischemic mice. MR 409 also inhibits the in vivo growth of lung cancer.

(+)-Butin is the R enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.

Guaiacol Carbonate acts as an expectorant by virtue of a reflex from the stomach by way of the afferent gastric nerves to the medullary centres and thenperipherally again to the respiratory tract.

NLRP3 / aim2-in-2 is a new potent inhibitor with different species-specific effects on NLRP3 and aim2 inflammasome dependent cell death. Its < b > IC < sub > 50 < / sub > < / b > value is 0.2392 ± 0.0233 μ M。

NLRP3/AIM2-IN-1 is a thermal sepsis inhibitor with an < b > IC < sub > 50 < / sub > < / b > value of 3.136 ± 0.7667 μ M.

Toluidine Blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components. Toluidine Blue has wide applications in vital staining in living tissues and a special stain.

R110 is a potent, competitive inhibitor of MIF2 tautomerase with an IC50 of 15 μM. R110 has the potential for the research of cancer diseases.

NF-κB-IN-2 inhibits TNF-α-induced canonical NF-κB signaling in PC-3 cells.

Kanshone C is a sesquiterpenoid of Nardostachys chinensis roots.

Paneolilludinic acid is a compound isolated from an endolichenic fungus Cryptomarasmius aucubae. Paneolilludinic acid significantly inhibits nitric oxide (NO) production.

Rinderine N-oxide is a pyrrolizidine alkaloid that can be found in R. graeca.

Echinatine N-oxide is a pyrrolizidine alkaloid found in R. graeca.

(-)-10,11-Dihydroxyfarnesol is a compound isolated from an endolichenic fungus Cryptomarasmius aucubae. (–)-10,11-Dihydroxyfarnesol significantly inhibits nitric oxide (NO) production.

Carviolin is a compound isolated from the mycelia of the ascomycete Neobulgaria pura. Carviolin inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. Carviolin exhibits moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities.

NLRP3/AIM2-IN-3 is a unique molecule that inhibits the activation of < b > NLRP3 < / b > and < b > AIM2 < / b > inflammatory bodies and has species differences. Its < b > IC < sub > 50 < / sub > < / b > value is 0.077 ± 0.008 μ M。

Trans substituted cephalosporin is an effective NDM-1 inhibitor，with an IC50 value of 0.13 μM.

Myt1-IN-1 is a potent Myt1 inhibitor with an IC50 of <10 nM. Myt1-IN-1 has anticancer effects (WO2021195782A1; compound 132).

4-((4-((4-Aminophenyl)sulfonyl)phenyl)amino)-4-oxobutanoic acid is a sulfonamide antiinfective agent.

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative found in the fungus Kirschsteiniothelia species.

Talaroenamine F is active against Bacillus cereus with an MIC value of 0.85 μg/mL.

Biotin-4-aminophenol is a biotin-phenol analog. Biotin-4-aminophenol generates free radicals and conjugates to tyrosine residues in proteins more efficiently and selectively than the previously reported BP1.

6-(3,4,5-Trimethoxybenzamido)hexanoic acid is an antiarrythmic agent.

PptT-IN-3 (compound 5p) is a potent inhibitor of with phosphopantetheinyl phosphoryl transferase (PptT) an IC50 of 3.5 μM. Phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. PptT-IN-3 has the potential for the research of tuberculosis.

BIOTIN-PEG11-SH enables biotin labeling of protein.

Thymotrinan (RGH-0205) is a biologically active fragment of the naturally occurring thymus hormone thymopoietin and a immunomodulating peptide. Thymotrinan exerts similar immunomodulatory activities to TP5 and to affect humoral as well as cellular responses.

2-hexyldecanoic acid can be used as an amidating agent .

Lonazolac is a non-steroidal antirheumatic agent. Anti-inflammatory effects .

photoCORM-2 (compound 3) is a single carbon monoxide releasing molecule (CORM). photoCORM-2 exhibits good cellular uptake and real-time monitoring ability of CO uncaging by a color change approach. photoCORM-2 has anti-tumor activity.

9-Demethyl FR-901235 is the 9-demethyl derivative of immunomodulator FR-901235.

α-Obscurine is a lycodine-type alkaloid.

Lascivol is a bitter compound isolated from Tricholoma species.

RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.

Antitumor agent-31 is a nanosized chelates of anchoring bisazo dye. Antitumor agent-31 can be used for an antioxidant and antitumor agent.

TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 µM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice.

Myt1-IN-2 is a potent Myt1 inhibitor with an IC50 of <10 nM. Myt1-IN-2 has anticancer effects (WO2021195782A1; compound 28).

RXFP3 agonist 1 is a nonpeptide RXFP3 agonist (EC50=6937 nM).

Myt1-IN-3 is a potent Myt1 inhibitor with an IC50s of <10 nM (WO2021195782 A1, compound 95).

Integerrimine N-oxide, the main pyrrolizidine alkaloid found in the butanolic residue (BR) of Senecio brasiliensis. Prenatal exposure to integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delays in physical and behavioral development of the offspring.

Biotin-aniline is a probe with substantially high reactivity towards RNA and DNA. Biotin-aniline emerges as more efficient probe for capturing subcellular transcriptome in living cells with high spatial specificity.

PptT-IN-1 (compound 5j) is a potent inhibitor of with phosphopantetheinyl phosphoryl transferase (PptT) an IC50 of 2.8 μM. Phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. PptT-IN-1 has the potential for the research of tuberculosis.

GEM–IB is the conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB). GEM–IB as a single agent or in combination with Docetaxel (DTX) demonstrates reduced tumor burden, preservation of the bone architecture, and improved the survival in a murine model of osteosarcoma (OS).

Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .

Difenpiramide (Z-876) is a bisphenylalcanoic derivative with marked anti-inflammatory, analgesic, antipyretic and uricosuric properties. Difenpiramide has platelet anti-aggregation activity.

5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA analog. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation.

KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM.

Clomipramine (Chlorimipramine) is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD).

Gibberellin A1 is a kind of plant hormones. Gibberellin A1 is a growth-promoting acids isolated from immature seed of Phaseolus multiflorus.

TLR4/NF-κB/MAPK-IN-1 is a new type of antineuroinflammatory agent by suppressing TLR4/NF-kB/MAPK pathways.

Tetrahydroauroglaucin is a member of hydroquinones, with antioxidative effects.

Britannilactone diacetate shows potential antiinflammatory, antibacterial, antihepatitic, antidiabetes, and antitumor activities.

Sterpurol D is a compound of the sterpurane sesquiterpenoid. Sterpurol D significantly inhibits nitric oxide (NO) production.

BTTAA-OH is a kind of tris(triazolylmethyl)amine compound. BTTAA-OH has the potential for the research of labeling and/or imaging in living system (extracted from patent WO2012021390A1).

Azido-FTY720 is a photoactivatable analogue of FTY720. Azido-FTY720 is used for identifying binding sites between FTY720 and its receptors.

Pristane (Norphytane) is a naturally occurring hydrocarbon oil found in small quantities in many plants, in various marine organisms, and as the most active component of mineral oil. Pristane is a non-antigenic adjuvant, and induces MHC class II-restricted, arthritogenic T cells in the rat.

Dual photoCORM 1 (compound 5) is metal-free, photochemically active dual CORM. Dual photoCORM 1 exhibits good cellular uptake and real-time monitoring ability of CO uncaging by a color change approach in cancerous B16F10 cells.

Stemphyperylenol displays a potent antifungal activity against the plant pathogen Alternaria solani with MIC of 1.57 μM.

PI5P4Ks-IN-1 (compound 7) is an active compound with no detectable inhibition of the PI5P4K α or β isoforms.

Phenolphthalol is a laxative in drug preparations and also estrogenically active.

Licoisoflavanone is the isoflavonoid compound isolated from Sinkiang licorice root (Glycyrrhiza).

Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. It can readily intercalate into biological macromolecules, including DNA and proteins. Safranin can be used as a redox indicator in the determination of metal ion concentration.

1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is an anticholinergic agent. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol has the potential for the research of bronchial asthma.

R-PSOP is highly potent and selective nonpeptidic NMUR2 antagonist. R-PSOP binds to NMUR2 with the Kis of 52 and 32 nM for the human and rat NMUR2, respectively. R-PSOP shows moderate CNS penetration. R-PSOP can be used for the research of the eating disorders, obesity, pain, and stress-related disorders.

Scabronine M is a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells.

Paecilaminol (FKI-0550) is potent NADH-fumarate reductase inhibitor. Paecilaminol exhibits an IC50 value of 5.1 μM against Ascaris suum NADH-fumarate reductase.

Eosin Y is a dye molecule. Eosin Y has low cost and good availability which has a wide application in organic synthesis as a photoredox catalyst.

Ethyl linoleate-13C18 (Linoleic Acid-13C18 ethyl ester) is the 13C labeled Ethyl linoleate. Ethyl linoleate inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators.

MPGES-1 is considered as a promising therapeutic target of the next generation anti-inflammatory drugs in the treatment of inflammatory diseases. The < b > IC < sub > 50 < / sub > < / b > value of mPGES-1-IN-1 is 0.03 μ M。

NSC 828467 exhibited significant in vitro anticancer activity,and it is one of the top-five CA IX inhibitors with an IC50 value of 27.2nM.

Glyasperin C is a potent and reversible noncompetitive inhibitor of neuraminidase with an IC50 of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis.

7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine[1].

Malabaricone C is a natural sphingomyelin synthase (SMS) inhibitor with IC50s of 3 and 1.5 μM for SMS 1 and 2, respectively.

Septeremophilane E is a compound isolated from fungus Septoria rudbeckiae, a plant pathogenic fungus isolated from the halophyte Karelinia caspia. Septeremophilane E significantly inhibits the production of nitric oxide (NO).

Wybutosine is a modified base adjacent to the anticodon of tRNA(Phe).

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium is a dinucleotide cap analog that can be used for in vitro RNA transcription.

Reactive Blue 19 is an anthraquinone dye used in the textile industry as a starting material to produce polymeric dye.

Considerable studies confirmed that BRD4 inhibition ameliorated kidney injury and fibrosis ，and ZLD2218 exhibited the most potent inhibitory activity against BRD4, with the IC50 value of 107 nM

FGFR2-IN-1 is a selective FGFR2 inhibitor with an IC50 of 140 nM.

(R)-ONO-2952 is a R-enantiomer of ONO-2952. ONO-2952 is a potent, selective and orally active TSPO antagonist with Kis of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes.

10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.

RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM.

XN methyl pyrazole improves diet-induced obesity and induces energy expenditure in high-fat diet-fed mice.

Herpotrichone A shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC50) value of 0.41 μM.

Herpotrichone B shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC50) value of 0.11 μM.

PptT-IN-2 (compound 5k) is a potent inhibitor of with phosphopantetheinyl phosphoryl transferase (PptT) an IC50 of 2.5 μM. Phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. PptT-IN-2 has the potential for the research of tuberculosis.

BChE-IN-2 (compound 22) is a potent inhibitor of BChE with a Ki of 0.099 μM. BChE-IN-2 is a pyrimidine and pyridine derivative. BChE-IN-2 has the potential for the research of Alzheimer’s disease (AD) .

JBIR-15 is a new aspochracin derivative. JBIR-15 is isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04.

Docosane, a straight chain alkane, can be used to synthesize structural composites with thermal energy storage/release capability.

Analgesic agent-1, a potent analgesic agent, shows significant analgesic effect.

PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay (extracted from patent CN113402447A).

Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect.

Aszonalenin is a metabolite of Aspergillus zonatus.

Folipastatin is a potent inhibitor of phospholipase A2 with an IC50 of 39 μM. Folipastatin is a new depsidone compound from Aspergillus unguis.

Maximiscin, a fungal metabolite, induces DNA damage and shows selective cytotoxic activity against a subtype of triple-negative breast cancer.

SIK1 activator 1 exhibited remarkable inhibitory activity on hepatic gluconeogenesis by enhancing the SIK1 phosphorylation and ameliorated the hyperglyceamia of type 2 diabetic mice.

PfPKG-IN-1 is a imidazole-based inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG).

Kotanin is a metabolite of Aspergillus glaucus.

ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin.

Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC50 of 7.9 µg/ml.

Antiviral agent 14 is an antiviral agent against the tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). The EC50 values of Antiviral agent 14 against TMV and CMV with EC50 values of 135.5 μg/mL and 178.6 μg/mL, respectively.

(+)-Pileamartine A is a complex alkaloid. (+)-Pileamartine A can be accessed via intramolecular Pd(0)-catalyzed alkene 1,2-aminoarylation reactions.

Antalarmin (hydrochloride) is a non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.

Aspochalasin M is a colorless solid. Aspochalasin M shows modest activity against HL-60 cells with an IC50 of 20.0 μM. Aspochalasin M has the potential for the research of leukemic disease.

PLAP-IN-1 is a potent (IC50 = 32 nM) and selective PLAP inhibitor, with no detectable inhibition of tissue non-specific alkaline phosphatase (TNAP) activity.

5-Carboxytetramethylrhodamine can be used as a fluorescent probe of nucleic acids and proteins. 5-Carboxytetramethylrhodamine displays excitation maxima of 558 nm and an emission maximum of 586 nm.

DiSC3(5) is a fluorescent probe often used as a tracer dye to assess the mitochondrial membrane potential.

Solvent violet 9 is a dye for recognizing DNA.

Anhydro-6-epiophiobolin A, an analog of Ophiobolin A, is a potent inhibitor of photosynthesis (I50s of 6.1 and 1 mM for photosynthesis in Chlorella and Spinach, respectively).

Bunamidine hydrochloride is a veterinary anti-platyhelmintic agent used for Echinococcus granulosus and Taenia hydatigena.

24:0 Lyso PC-13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery.

MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases.

Pan-RAF kinase inhibitor 1 is a potent inhibitor of Pan-RAF kinase. Pan-RAF kinase inhibitor 1 regulates MAPK signaling by inhibiting RAF kinase, thereby exerting an effect on the proliferation of RAS-mutant tumor cells. Pan-RAF kinase inhibitor 1 has the potential for the research of cancer diseases (extracted from patent WO2021110141A1, compound 16B).

ZY-444 is a small molecule that suppresses breast cancer progression by targeting pyruvate carboxylase.

Myoferlin inhibitor 1 is a novel agent against pancreatic cancer metastasis through targeting myoferlin.

Clomifene hydrochloride is an orally active compound used for infertility. Clomifene hydrochloride is a simple, relatively safe, easily administered and well-tolerated efficacious compound to induce ovulation.

APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease.

Basic Blue 20 is a very convenient red-emitting DNA stains. Basic Blue 20 has relatively narrow excitation and emission spectra, with peaks at 633 and 677 nm, respectively. Basic Blue 20 also has a very high resistance to photobleaching.

Epothilone D1 is an isolated natural product that shows cytotoxicity against mouse fibroblasts.

Phytochelatin 3 (PC 3) is the small metal chelating peptide that can be used for chelating heavy metals.

Talotrexin ammonium is a nonpolyglutamatable antifolate. Talotrexin ammonium improves antitumor activity in a broad spectrum of cancer models by targeting DHFR to inhibit tumor growth.

BCL6-IN-6 is a potent inhibitor of transcriptional repressor B-cell lymphoma 6 (BCL6). BCL6-IN-6 significantly blocks the interaction of BCL6 with its corepressors and reactivates BCL6 target genes in a dose-dependent manner. BCL6-IN-6 has the potential for the research of diffuse large B-cell lymphoma (DLBCL).

Roquefortine E is a diketopiperazine from an Australian isolate of Gymnoascus reessii.

14α-Hydroxy Paspalinine is a paspalinine derivative with antiinsectan activity from the sclerotia of Aspergillus nomius.

DiOC5(3) is the membrane potential (MP)-modifying fluorochrome. DiOC5(3) is an anti-LSC compound available for diagnostic imaging. DiOC5(3) has the advantage of being a single fluorescent chemical.

The compound 19 (QW30) shows potent antitumor activity with an IC50 value of 0.33 μM.

Pycnophorin significantly inhibits the growth of Bacillus subtilis and Staphyloccocus aureus with equal minimum inhibitory concentration (MIC) values of 25 μM.

Bufospirostenin A is the first spirostanol to be isolated from an animal.

Beauveriolide I is the metabolite of Entomopathogenic Fungi Beauveria sp.. Beauveriolide I (1) exhibits moderate insecticidal activities against Spodoptera litura and Callosobruchus chinensis.

Beauveriolide III is an inhibitor of lipid droplet formation in mouse macrophages.

Epicoprostanol is the compound found in adipocere.

Sycosterol A is an α-synuclein (α-syn) inhibitory sterol.

YQ456 is a novel small molecule inhibitor of myoferlin that showed high binding affinity to myoferlin with a KD of 37 nM and excellent anti-invasion capability with an IC50 of 110 nM.