| Cas No.: | 1282041-94-4 |
| Chemical Name: | DSM265 |
| Synonyms: | DSM265;2-(1,1-Difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine |
| SMILES: | S(C1C([H])=C([H])C(=C([H])C=1[H])N([H])C1=C([H])C(C([H])([H])[H])=NC2=NC(C(C([H])([H])[H])(F)F)=NN12)(F)(F)(F)(F)F |
| Formula: | C14H12F7N5S |
| M.Wt: | 415.332405090332 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | DSM265 is a PfDHODH inhibitor with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM. |
| References: | [1]. Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31. |
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| 2018-0101 |
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