| DC12268 |
(3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine hydrochloride) |
(3-Carboxypropyl)trimethylammonium chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat. |
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| DC20603 |
(5Z)-7-Oxozeaenol |
(5Z)-7-Oxozeaenol is a potent and selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively. |
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| DC10426 |
(E)-[6]-Dehydroparadol |
(E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively. |
-[6]-Dehydroparadol .gif)
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| DC10832 |
(E/Z)-4-hydroxy Tamoxifen
Featured
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(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen that is formed by the action of cytochrome P450 2D6 in human liver. |
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| DC8964 |
Phenylephrine hydrochloride |
(R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and an α1-adrenoceptor agonist |
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| DC9584 |
(R)-(-)-Rolipram |
(R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4.
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| DC9533 |
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid |
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide.
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| DC22808 |
(R)-9bMS |
(R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM. |
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| DC9450 |
(R)-Baclofen |
(R)-Baclofen(STX209) is a selective GABAB receptor agonist. |
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| DC10388 |
(R)-BPO-27 |
(R)-BPO-27 is a potent CFTR inhibitor with an IC50 of 4 nM |
-BPO-27.gif)
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| DC20882 |
(R)-CE3F4 |
(R)-CE3F4 is a more potent, selective EPAC1 antagonist than the racemic CE3F4 and (S)-CE3F4, displays 10-fold selectivity for EPAC1 over EPAC2.. |
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| DC11364 |
Levocetirizine；(R)-Cetirizine (hydrochloride) |
(R)-Cetirizine is the (R)-enantiomer of the histamine H1 receptor antagonist and second generation antihistamine cetirizine. |
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| DC23692 |
(R)-DNMDP |
(R)-DNMDP (DNMDP R-form) is the R-form of is DNMDP, which is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12).. |
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| DC11952 |
(R)-DRF053 dihydrochloride |
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively. |
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| DC23181 |
(R)-GNE-140
Featured
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(R)-GNE-140 (GNE-140) is a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively. |
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| DC20290 |
(R)-HZ05 |
(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.. |
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| DC10521 |
(R)-IMPP
Featured
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(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 µM). |
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| DC9092 |
(R)-Lansoprazole |
(R)-Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid. |
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| DC12403 |
(R)-ND-336
Featured
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(R)-ND-336 is a potent and selective small-molecule MMP-9 inhibitor with Ki of 19 nM, weakly inhibits MMP-2 and MMP-14 (Ki=127 and 119 nM), poorly inhibits other MMPs (Ki>10 uM). |
-ND-336 (1).gif)
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| DC11488 |
USP7-IN-4 |
(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays. |
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| DC20594 |
(R)-ZINC-3573
Featured
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(R)-ZINC-3573 is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=0.76 uM), showing little activity against 315 other GPCRs and 97 representative kinases. |
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| DC20247 |
(R,R)-BNC375
Featured
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(R,R)-BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs. |
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| DCAPI1481 |
Sulpiride |
(RS)-(±)-Sulpiride is a selective postsynaptic D2DR inhibitor. |
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| DC23000 |
(-)-Perillyl alcohol
Featured
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(S)-(-)-Perillyl alcohol is a monoterpenoid compound found in the essential oils of cherries, lavender and spearmint. |
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| DC9581 |
(S)-(+)-Rolipram |
(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.
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| DC26029 |
(S)-4CPG |
(S)-4CPG, also known as (S)-4-Carboxyphenylglycine, is a novel orally active metabotropic glutamate receptor 1 antagonist. |
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| DC23811 |
(S)-BAY-293(BAY293 S-enantiomer) |
(S)-BAY-293 (BAY293 S-enantiomer) is the S-enantiomer of BAY-293 as a negative control compound.. |
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| DC8451 |
(S)-Equol
Featured
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(S)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM). |
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| DC20595 |
(S)-FQI1 |
(S)-FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.93 uM, approximately 2-fold more active than the racemate FQI-1. |
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| DC9368 |
(S)-Gossypol (acetic acid) |
(S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM).
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