| DC7660 |
Go 6983
Featured
|
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ. |
|
| DC22100 |
GO289
Featured
|
GO289 (GO-289, GO 289) is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM in in vitro kinase assays, shows minor effects on CKIδ and CKIα activity in vitro. |
|
| DC20393 |
Golgicide A
Featured
|
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM. |
|
| DC26017 |
Golotimod (SCV-07)
Featured
|
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. |
|
| DC23028 |
Gomisin A
Featured
|
Gomisin A has anti-inflammatory, antihypertensive, neuroprotective, and anti-proliferation properties, it induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal tran |
|
| DCAPI1148 |
Gossypol |
Gossypol |
|
| DC12542 |
GOT1 inhibitor 2c
Featured
|
GOT1 inhibitor 2c is a first-in-class, non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with IC50 of 8.2 uM.. |
|
| DC9375 |
GPDA
Featured
|
GPDA(Glycylproline p-nitroanilide tosylate) is the substarate of X-Prolyl dipeptidyl-aminopeptidase in the enzyme assay. |
|
| DC7137 |
Filgotinib(GLPG0634)
Featured
|
Filgotinib (GLPG0634) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. Filgotinib can effectively inhibit the activities of JAK1, JAK2, JAK3 and TYK2 with IC50 values of 10 nM, 28 nM, 810 nM and 116 nM, respectively. Filgotinib also inhibits HIV-1 driven gene transcription and reduces proliferation of HIV-1 infected cells. Filgotinib can be used in the study of rheumatoid arthritis and inflammatory bowel disease. |
|
| DC8593 |
GPR120 Compound A
Featured
|
GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 µm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1). |
|
| DC21902 |
GPR139 agonist AC4 |
GPR139 agonist AC4 is a novel small molecule GPR139 receptor agonist with EC50 of 220 nM in calcium mobilization assay in CHO-GPR139 cells. . |
|
| DC20394 |
GPR39 modulator 3 |
GPR39 modulator 3 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=5 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels. |
|
| DC20395 |
GPR39 modulator 7 |
GPR39 modulator 7 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=20 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels. |
|
| DC8206 |
GPR39-C3
Featured
|
GPR39-C3 is the first potent, selective and orally bioavailable GPR39 agonist with an EC50 ~0.8 nM for human GPR39 and ~0.4 nM for rodent GPR39. |
|
| DC20076 |
GPR4 antagonist 3(NE 52-QQ57 )
Featured
|
GPR4 antagonist 3 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. Anti-inflammatory activities. |
|
| DC11143 |
GPR40 AgoPAM AP5 |
GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM). |
|
| DC22224 |
Gpr52 antagonist E7 |
Gpr52 antagonist E7 (Scabertopin) is a novel Gpr52-specific small molecule antagonist, reduces mutant HTT levels and rescues Huntington's disease-associated phenotypes in cellular and mouse models.. |
|
| DC26114 |
GpTx-1
Featured
|
GpTx-1 is a potent, selective, 34-residue peptide antagonist of Nav1.7 sodium channel with IC50 of 10 nM, displays 20- and 1000- fold selectivity over NaV1.4 and NaV1.5.. |
|
| DC21064 |
GR-127935 hydrochloride
Featured
|
GR-127935 potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor. |
|
| DC8820 |
GR148672X |
GR148672X is a specific TGH inhibitor. |
|
| DC11090 |
GR3027
Featured
|
GR3027 (Golexanolone) is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC. |
|
| DC21065 |
GR-64349 |
GR-64349 is a potent and selective tachykinin NK2 receptor agonist with EC50 of 3.7 nM, displays >1000- and >300-fold selectivity over NK1 and NK3 receptors, respectively.. |
|
| DC21066 |
GR73632
Featured
|
GR-73632 is a potent and selective tachykinin NK1 receptor agonist with EC50 of 2 nM, promotes differentiation but not survival of rat chromaffin cells in vitro.. |
|
| DC9299 |
GRA Ex-25
Featured
|
GRA Ex-25 is an orally active human glucagon receptor antagonist in a transgenic murine pharmacodynamic model at 10 and 30 mpk. |
|
| DC9918 |
Gracillin |
Gracillin is a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica with antitumor agent. |
|
| DC9080 |
Granisetron HCl |
Granisetron Hcl(BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. |
|
| DCAPI1367 |
Grape Seed Extract |
Grape Seed Extract |
|
| DC12095 |
GRGDSP TFA |
GRGDSP (TFA) is an integrin inhibitor. |
|
| DC22629 |
GRL-0617
Featured
|
GRL-0617 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM. |
|
| DC23564 |
GS 462808 |
GS 462808 is a potent Late INa current inhibitor with IC50 of 1.33 uM. |
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