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Cat. No. Product name CAS No.
DC74022 IDE-397 Featured

IDE-397 (GSK-4362676, GSK-676) is a potent, selective small molecule methionine adenosyltransferase 2a (MAT2A) inhibitor, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts.

2439277-80-0
DC74023 IGGi-11

IGGi-11 is a first-in-class small molecule inhibitor of non-canonical activation of heterotrimeric G-protein signaling, binds to G-protein α-subunits (Gαi, Gαi3 ITC Kd=4 uM), specifically disrupts their engagement with GIV/Girdin.

303059-39-4
DC74024 IGGi-11me

IGGi-11me is a specific, cell-active small molecule inhibitor of GIV-dependent G-protein cell signaling, binds to G-protein α-subunits, specifically disrupts their engagement with GIV/Girdin.

DC74025 IMB0901

IMB0901 is a small molecule myostatin (MSTN) inhibitor that inhibits the MSTN promoter activity, the MSTN signaling pathway, and the MSTN positive feedback regulation.

890896-32-9
DC74026 INH-12

INH-12 is a selective small-molecule HSD17B12 inhibitor with 70% inhibition of HSD17B12 activity to transform estrone (E1) into estradiol (E2) at 1 uM, reduces the replication of Flaviviridae viruses (HCV, DENV and ZIKV).

DC74027 InhiTinib

InhiTinib is a small molecule that inhibit interferon (IFN)-gamma production (IC50=52.44 nM) and proliferation of primary CD3+ T cells without inducing cell death.

847241-68-3
DC74028 INI-60

INI-60 (Inhibitor of Nuclear Import-60) is a novel small molecule inhibitor of Kpnβ1-mediated nuclear import with anti-cancer activity.

1070406-71-1
DC74029 IOI-214

IOI-214 is a potent inhibitor of LPS-induced inflammatory cytokine production, prevent HF diet-induced NAFLD/MAFLD in vivo.

78349-84-5
DC74030 IOI-42

hPEBP4 inhibitor IOI-42 is a small molecule inhibitor of anti-apoptotic protein hPEBP4, potentiates TNF-α-mediated growth inhibition of MCF-7 breast cancer cells.

438212-73-8
DC74031 IPA

IPA (Inhibitor of Priming Activity) is a small-molecule compound that binds Sec18 (Kd=3.84 uM) and blocks SNARE activation, inhibits vacuole fusion at the SNARE priming stage with IC50 of 50 uM.

200348-48-7
DC74032 IP-DNQ

IP-DNQ (Isopentyl-deoxynboquinone) is a small molecule that selectively kills pancreatic ductal adenocarcinoma cells in an NQO1-dependent manner.

1430798-23-4
DC74033 Ipfencarbazone

Ipfencarbazone is a substance being developed for the control of weeds such as watergrass in rice, herbicide agent.

212201-70-2
DC74034 IPHBA

IPHBA is a small-molecule inhibitor that suppresses EPAS1-driven IL-31 induction, selectively inhibits TCR-mediated IL-31 induction in murine CD4+ T cells with IC50 of 10.6 uM.

325777-00-2
DC74035 Ironomycin

Ironomycin (Ironomycin AM5) is a lysosomal iron-targeting small molecule that reduces the mitochondrial iron load, resulting in the potent disruption of mitochondrial metabolism.

DC74036 iSB09

iSB09 is a potent, selective small moelcule abscisic acid (ABA) receptor agonist with HAB1 IC50 value of 316 nM (combined with the engineered CsPYL1 ABA receptor CsPYL15m).

DC74037 JA310

JA310 is a potent, highly selective inhibitor of the mammalian sterile 20-like serine/threonine (MST) family member MST3 (STK24) with ITC KD value of 115 nM.

3022928-90-8
DC74038 JBSNF-000028

JBSNF-000028 (JBSNF000028) is a potent, selective, orally bioavailable substrate-analog inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 of 34 nM, 190 and 210 nM against human, monkey and mouse NNMT, respectively.

DC74039 JNJ 74856665

JNJ74856665 (JNJ74856665) is an orally available, potent and selective DHODH inhibitor with IC50 values in the subnanomolar range.

2641340-35-2
DC74040 JNJ-54302833

JNJ-54302833 (JNJ 54302833) is a potent, selective fatty acid synthase (FASN) inhibitor with IC50 of 28 nM.

1579514-16-1
DC74041 JSD26

JSD26 is a selective S-nitroso-coenzyme A reductase 2 (SCoR2; AKR1A1) inhibitor with Ki of 93 nM, 10-fold selectivity over AKR1B1.

2353515-08-7
DC74042 JumOCA peptide

JumOCA peptide (VKELLRRKRGH) is a peptide corresponding to the OCA-B N terminus, membrane-penetrating OCA-B peptide inhibitor.

DC74043 JumOCA peptide Tat

JumOCA peptide Tat is a a peptide corresponding to the OCA-B N terminus, as C-terminal fusions to the HIV trans-activator of transcription (Tat) protein for membrane permeability.

DC74044 JYFY-001

JYFY-001 is a small molecule copper chelator with moderate selectivity for targeting copper, potently inhibits cancer proliferation.

2756734-42-4
DC74045 JYQ-88

JYQ-88 is a potent, selective and covalent PARK7 inhibitor with IC50 of 0.13 uM in DiFMUAc assays, 100-fold selectivity over UCHL1 (PARK5, IC50=11.1 uM), covalently modifies the active site Cys106.

2987636-71-3
DC74046 K786-4469

K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1), suppresses cancer metastasis in vitro and in vivo.

705955-57-3
DC74047 Kakeimide Featured

Kakeimide is a potent GH3 inhibitor that selectively targets IAA-conjugating GH3 proteins at subnanomolar concentrations in vitro, shows auxin-like activity by inhibiting endogenous IAA catabolism.

928975-34-2
DC74048 Karyostatin 1A

Karyostatin 1AKaryostatin 1A is a small molecule inhibitor of importin beta with binding affinity (Kd=0.3 uM), selectively inhibits the importin α/β pathway.

1246468-20-1
DC74049 KBP-066

KBP-066 is a potent, selective dual amylin and calcitonin receptor agonist induces an equally potent body weight loss across a broad dose range in obese rats.

DC74050 KIO-100

KIO-100 (PP-001) is a novel potent, specific small molecule inhibitor of DHODH with IC50 of <4 nM, 150-fold higher potency than leflunomide (IC50 of 650 nM).

717142-73-9
DC74051 KL101

KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1).

396721-89-4
DC74052 KP-1019

A ruthenium complex anticancer agent that is useful for metastatic tumors and cis-platin resistant tumors.

DC74053 KP-1339

A promising ruthenium anticancer compound that blocks angiogenesis, endothelial cell proliferation and migration stimulated by VEGF or NO donor agent.

DC74054 KRP-6

KRP-6 is a potent and highly selective macrophage migration inhibitory factor (MIF) ketonase inhibitor with IC50 of 4.31 uM, significantly reduces MIF-induced neutrophil migration.

DC74055 KS10076

KS10076 is a metal chelator with potent anti-cancer cytotoxicity, destabilizes STAT3 by elevating ROS, shows remarkable cytotoxic efficacy in 100 cancer cell lines of different types with IC50 of <1 uM.

DC74056 KVS0001

KVS0001 is a specific and bioavailable small molecule inhibitor of SMG1 kinase, disrupts nonsense mediated decay (NMD).

DC74057 KZR-8445

KZR-8445 (KZR8445) is a cyclic depsipeptide, client-selective Sec61 inhibitor with IC50 of 100 nM, targets the Sec61 translocon and selectively modulate Sec61-mediated protein biogenesis.

2377734-91-1
DC74058 L6H21

L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex.

24533-47-9
DC74059 LI-2242

LI-2242 is a potent pan-IP6K inhibitor with IC50 of with IC50 of 31, 42 and 8.1 nM for IP6K1, IP6K2 and IP6K3, respectively.

2762762-17-2
DC74060 LP-403812

LP-403812 is a specific small molecule inhibitor of mammalian proline transporter (PROT), inhibits PROT-mediated proline uptake with IC50 of 0.1 uM on both recombinant human and mouse PROT.

1142050-84-7
DC74061 LSALT peptide

Metablok (LSALT peptide) is a specific DPEP1-binding peptide and nonenzymatic dipeptidase-1 (DPEP-1) inhibitor.

DC74062 L-Thyroxine sodium salt pentahydrate

A manufactured form of the thyroid hormone thyroxine (T4) that typically used to treat hypothyroidism.

6106-07-6
DC74063 LX-6171

LX-6171 is a small molecule proline transporter (SLC6A7) inhibitor with potential for treating cognitive and other disorders.

914808-66-5
DC74064 Macrocyclic peptide D4-2 Featured

Macrocyclic peptide D4-2 is a macrocyclic peptide consisting of 15 amino acids that binds to the ectodomain of mouse SIRPα (Kd=10 nM, IgV-B6 SIRPα) and efficiently blocks CD47-SIRPα interaction in an allosteric manner (IC50=0.18 uM).

DC74065 MASM7

MASM7 is a small molecule activator of mitochondrial fusion via mitofusins (MFN1 and MFN2), concentration-responsively increases mitochondrial aspect ratio (Mito AR) in MEFs with EC50 of 75 nM, directly and specifically modulates MFN1/2 fusogenic activity

920868-45-7
DC74066 MCI-100

MCI-100 is a small molecule that displays greater potency than sulindac to protect RPE cells against oxidative damage, with lacked significant COX inhibitory activity, MCI-100 is more active than sulindac in protecting cells against oxidative damage.

1945942-59-5
DC74068 MEISi-1

MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity.

446306-43-0
DC74069 Melatonin Biotin

Melatonin Biotin is compound conjuncted melatonin with biotin..

2193462-87-0
DC74070 Methyl-β-cyclodextrin

A cholesterol depleting agent that shows antitumor activity both in vitro and in vivo.

128446-36-6
DC74071 MIDI

MIDI (Mitochondrial division inhibitor) is a potent, covalent mitochondrial fission inhibitor, interacts with DRP1-C367 to block mitochondrial fission.

348145-43-7
DC74072 Mito-C

Mito-C is a specific chemical compound targeting NEETs proteins, induces mitochondrial network fragmentation and represses dengue viral replication.

2371004-96-3
DC74073 MitoCKi

MitoCKi (Creatine kinase inhibitor CKi-26) is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 185 nM, depletes creatine phosphagen energetics in cells.

DC74074 Mito-LND

Mito-LND (Mito-lonidamine) is a tumor-selective inhibitor of oxidative phosphorylation with IC50 of 1.2 and 2.4 uM for mitochondrial complexes I and II, respectively, impacts the activity of mitochondrial complexes, ROS generation and peroxiredoxin oxidat

2361564-49-8
DC74075 ML181

ML181 (CYM50557) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBW1) antagonist probe with IC50 of 270 nM for inhibition of NPW-induced GPR7 activation.

1415356-28-3
DC74076 MLS000544460

MLS000544460 (EYA2i) is a specific, allosteric inhibitor of Eya2 phosphatase with IC50 of 4.1 uM, KD of 2.0 uM, does not bind Eya3 ED, Eya1 and Eya4 ED.

352336-36-8
DC74077 MM0299

MM0299 (MM 0299) is a potent, selective inhibitor of lanosterol synthase (LSS, competition EC50=1.97 nM) with anti-proliferative activity, inhibits Mut6 cell growth (IC50=18.2 nM) and induces the synthesis of 24(S),25-epoxycholesterol (EPC).

474255-10-2
DC74078 MM0299 analog 13

MM0299 analog 13 (MM 0299 derivative 13) is a potent, selective, orally bioavailable, brain-penetrant inhibitor of lanosterol synthase (LSS, competition EC50=28.7 nM) with anti-proliferative activity.

DC74079 MN132.0262

MN132.0262 is a small molecule, dual inhibitor of A3G (APOBEC3G, IC50=20 uM).

1809295-17-7
DC74080 MN256.0102

MN256.0102 is a small-molecule APOBEC3G DNA cytosine deaminase inhibitor with IC50 of 3.9 uM.

872700-63-5
DC74081 MN256.0105

MN256.0105 is a small-molecule APOBEC3G DNA cytosine deaminase inhibitor with IC50 of 4.3 uM.

2497410-53-2
DC74082 MO-I-1100

MO-I-1100 is a small molecule inhibitor of aspartyl-(asparaginyl)-β-hydroxylase (ASPH), inhibits the β-hydroxylase activity of ASPH about 80%, inhibits Notch signaling in HCC cancer cells.

1585217-40-8
DC74083 MO-I-1182

MO-I-1182 is a small molecule inhibitor of aspartate beta-hydroxylase (ASPH), suppresses cholangiocarcinoma metastasis.

2477878-52-5
DC74084 MrgX1 modulator 8e

MrgX1 inhibitor 8e is a potent, allosteric modulator of MrgX1 with EC50 of 13 nM, showed improved potency and microsomal stability than ML382.

2700254-51-7
DC74085 MS0621

MS0621 (UNC0621, MS 0621) is a small-molecule modulator of EWSR1::FLI1-mediated chromatin, reverses EWSR1::FLI1-mediated chromatin accessibility, persistently and selectively inhibits cell proliferation in Ewing sarcoma cell lines (SK-N-MC, IC50=128 nM).

2031251-11-1
DC74086 msR4M-L1

msR4M-L1 is a chemokine-selective CXCR4 ectodomain mimic that selectively binds to MIF (KD<40 nM) but not CXCL12 (>140-fold selectivity).

DC74087 MY-9B

MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armad

DC74088 Nalacin

Nalacina is a small molecule that partially mimicks the effects of auxin and potent inhibitor of indole-3-acetic acid (IAA) conjugation mediated by group II GH3 (Gretchen Hagen 3) in vascular plants, inhibits Gretchen Hagen 3 (GH3) acyl acid amido synthet

1019105-44-2
DC74089 NCGC00108248

NCGC00108248 is small molecule inhibitor of Mir155 reporter, dose-dependently inhibits Mir155 reporter expression with EC50 of 2.2 uM.

901014-45-7
DC74090 NCGC00378430

NCGC00378430 (Compound 8430) is a novel small molecule compound that reduces the SIX1/EYA2 interaction in vitro with IC50 of 52 uM in the Alphascreen assay.

920650-00-6
DC74091 NCGC00507974

NCGC00507974 is a small molecule inhibitor of Mir155 reporter, dose-dependently inhibits Mir155 reporter expression with EC50 of 1.2 uM.

897768-32-0
DC74092 NCI-41356

NCI-41356 is a small molecular inhibitor of αB-crystallin (CRYAB, HSPB5), significantly reducesthe interaction between CRYAB and VEGF165.

910548-20-8
DC74093 NCP26 Featured

NCP26 is a potent, ATP-competitive prolyl-tRNA synthetase (ProRS, PRS) inhibitor, inhibits recombinant human ProRS in the presence of 100 μM proline with KD of 0.35 nM in TR-FRET assays.

2396683-89-7
DC74094 NERx 329

NERx 329 (RPAi 329, NERx329) is a novel potent, specific inhibitor of replication protein A (RPA), demonstrated potent RPA inhibitory activity in vitro, in vivo, and in cellular assays.

2649242-85-1
DC74095 Ninerafaxstat 3HCl Featured

Ninerafaxstat 3HCl (CV-8972) is a small molecule compound that promotes glucose oxidation, decreases fatty acid oxidation and improve overall mitochondrial respiration, inhibits the growth and proliferation of cancer cells.

2311824-72-1
DC74096 NIO-1

NIO-1 (Novel inhibitor of OCT1) is a novel small molecule inhibitor of Octamer transcription factor OCT1, inhibits OCT1 activation with IC50 of 0.11 uM.

2691184-09-3
DC74097 Nizubaglustat

Nizubaglustat is a potent, selective inhibitor of glucosylceramide synthase (GCS) with IC50 of 25 nM, inhibits acid glucosylceramidase (GBA1) and neutral glucosylceramidase (GBA2) with IC50 of 200 and 0.08 nM, respectively.

1633666-49-5
DC74098 NOX-6-18 Featured

NOX-6-18 is a potent, selective GPR132 antagonist with IC50 of 17 nM.

898211-21-7
DC74099 NOX-6-7

NOX-6-7 is a potent, selective GPR132 agonist with EC50 of 44 nM.

DC74100 NPD389

NPD389 is a potent, selective, fast-binding uncompetitive inhibitor of NADP+-dependent malic enzyme 2 (ME2) with IC50 of 4.63 uM, NPD389 is a mixed-type competitive inhibitor for the substrate L-malate and an uncompetitive inhibitor for the other substrat

38558-72-4
DC74101 NSC 773097

NSC 773097 is a RITA analog that produces hyperselective cytotoxicity while maintaining antitumor efficacy (A498 cell IC50=130 nM).

213261-61-1
DC74102 NSC33353

NSC33353 (NSC 33353) is a small molecule inhibitor with potent anti-tumor activity against TNBC cells, enhances TNBC sensitivity to doxorubicin.

109693-38-1
DC74103 NUP-17d-52A

NUP-17d-52A (Plek2 inhibitor) is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2-DEP domain with high affinity (Kd=160 nM).

2798048-94-7
DC74104 NV848

NV848 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo.

58535-41-4
DC74105 NV914

NV914 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo.

2341941-41-9
DC74106 NV930

NV930 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo.

37384-62-6
DC74107 NVS1.1

NVS1.1 is a potent readthrough promoter, promotes the rapid and specific degradation of eukaryotic release factor 1 (eRF1) and restores functional full-length proteins in cystic fibrosis and Hurler disease models.

DC74108 Opabactin

Opabactin is an abscisic acid (ABA) mimic and agonist Arabidopsis subfamily III/II ABA receptors with nanomolar potency (7 nM).

2407423-32-7
DC74109 Ophiopogonin D

Ophiopogonin-D (OP-D) is one of steroidal saponins isolated from the root of the Chinese medicinal plant Ophiopogon japonicas, possesses anti-inflammatory and anti-oxidant properties.

945619-74-9
DC74110 Org 214444-0

Org 214444-0 is a highly potent, selective, allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 2.0/1.2 nM (human/rat FSHR) in cell-based assays.

914093-78-0
DC74111 OSM-SMI-10B

OSM-SMI-10B (SMI-10B) is a first-in-class small molecule inhibitor binds to oncostatin M (OSM) with Kd of 13.6 uM, significantly reduces OSM-induced STAT3 phosphorylation in cancer cells.

2502294-55-3
DC74112 OV329

OV329 (OV 329) is a highly potent inactivator of gamma-aminobutyric acid aminotransferase (GABA-AT) with Ki of 9.69 uM.

DC74113 PAANIB-1

PAANIB-1 is a brain-penetrant PAAN/MIF nuclease inhibitor that prevents neurodegeneration that prevents neurodegeneration induced by α-syn PFF, AAV-α-syn overexpression, or MPTP intoxication in vivo.

2634726-71-7
DC74114 Panx-1 blocker 15b

Panx-1 blocker 15b is a large-pore channel pannexin 1 (Panx1) inhibitor with IC50 of 0.8 uM.

DC74115 PAT1inh-A0030 Featured

PAT1inh-A0030 is a potent and selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor with IC50 of 1.0 uM, shows no activity on relevant ion transporters/channels (SLC26A3, SLC26A4, SLC26A9, CFTR, TMEM16A).

1030097-65-4
DC74116 PAT1inh-B01 Featured

PAT1inh-B01 is a small-molecule, selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor, could fully inhibit PAT1-mediated anion exchange with IC50 of 350 nM.

1775330-54-5
DC74117 PCC0105003

PCC0105003 is a small molecule microtubule affinity-regulating kinases (MARKs) inhibitor with IC50 of 3.0, 2.0, 2.67 and 2.67 nM for MARK1, 2, 3 and 4 repectively.

DC74118 PCiB-1

PCiB-1 is a small molecule inhibitor capable of inhibiting phosphatidylcholine (PC) biogenesis with IC50 of 7.0 uM, inhibits phosphatidylethanolamine (PE) transport from mitochondria to the endoplasmic reticulum (ER), induces mitochondrial division.

626219-17-8
DC74119 PCiB-2

PCiB-2 is a small molecule inhibitor capable of inhibiting phosphatidylcholine (PC) biogenesis with IC50 of 2.0 uM, inhibits the phosphatidylethanolamine (PE) methyltransferase activity of Cho2, induces mitochondrial division.

731816-59-4
DC74120 PCiB-3

PCiB-3 is a small molecule inhibitor capable of inhibiting phosphatidylcholine (PC) biogenesis with IC50 of 0.4 uM, inhibits the phosphatidylethanolamine (PE) methyltransferase activity of Cho2.

298190-18-8
DC74121 PDDC

PDDC is the first potent, selective, orally-available, and brain-penetrable nSMase2 (neutral sphingomyelinase 2) inhibitor with pIC50 of 6.57.

2232878-43-0
DC74122 PEPCKi

PEPCKi is a small molecule inhibitor of hosphoenolpyruvate carboxykinase (PEPCK), blocks lactate utilization and impairs tumor growth in colorectal cancer.

628279-07-2
DC74123 PF-07208254

PF-07208254 (PF 07208254) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with in vitro IC50 of 110 nM and Ki of 54 nM.

2573122-40-2
DC74124 PF-07247685

PF-07247685 (PF-07247685) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with in vitro IC50 of 0.86 nM, and SPR Kd of 0.68 nM.

DC74125 PFKL activator NA-11 Featured

PFKL activator NA-11 is a small-molecule, selective PFKL activator, inhibits the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL).

2785323-65-9
DC74126 Pixatimod

Pixatimod (PG545) is a heparan sulfate (HS) mimetic and anticancer agent and a potent inhibitor of heparanase.

DC74127 PPA904

PPA-904 is a specific phenothiazine photosensitizer in photodynamic therapy (PDT) research, especially topical application for cutaneous leishmaniasis in vivo.

30189-85-6
DC74128 PQ912 Featured

Varoglutamstat (PQ912) is a potent glutaminyl cyclase (QC) inhibitor with Ki values of 20-65 nM for human, rat, and mouse QC activity.

1276021-65-8
DC74129 PRG-A01

PRG-A01 is a chemical inhibitor against SOD1 misfolding and aggregation, inhibits the neuronal cell death caused by mutant-SOD1 overexpression.

1848971-22-1
DC74130 PSB-22034

PSB-22034 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 11.2 nM/32.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.

2768131-22-0
DC74131 PSB-22040

PSB-22040 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 19.2 nM/30.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.

2768131-35-5
DC74132 PSB-CB-148

PSB-CB-148 is a potent, selective antagonist of GPR18.

DC74133 PSB-CB-27 Featured

PSB-CB-27 is a potent, selective antagonist of GPR18 with IC50 of 650 nM, shows no inhibition on GPR55 and low affinity for CB1/CB2 receptors.

2237222-16-9
DC74134 PSB-KK-1415

PSB-KK-1415 is a selective GPR18 agonist with EC50 of 19.1 nM (hGPR18) in β-arrestin recruitment assays, shows no activity against GPR55.

DC74135 PT-91

PT91 is a small-molecule GPR27 (SREB1) agonist with pEC50 of 6.15 (human GPR27) in β-arrestin 2 recruitment-based firefly luciferase complementation assay, Emax=100%.

DC74136 PTI-125

PTI-125 (Simufilam, Sumifilam) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation.

1224591-33-6
DC74137 PXS-4787 Featured

PXS-4748 (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.

2409963-50-2
DC74138 PXS-5129A

PXS-5129A is the pro-drug form of PXS-5120A, a potent, selective, irreversible inhibitor of Lysyl oxidase-like 2 (LOXL2).

2125955-76-0
DC74139 PXS-5505 dihydrochloride monohydrate

PXS-5505 dihydrochloride monohydrate is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (pan-LOX) family members, with potential antifibrotic activity.

2414974-55-1
DC74140 PXS-6302

PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.

2584947-54-4
DC74141 Pyrcoumin

Pyrcoumin is a competitive inhibitor of dCTP pyrophosphatase 1 (dCTPP1, IC50=3.3 uM), inhibits Wnt signaling with IC50 of 8.4 uM in SuperTOPFlash reporter gene assays.

1648814-86-1
DC74142 QP5038

QP5038 is a potent inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with IC50 of 3.8 nM, shows promising in vitro and in vivo anti-tumor efficacies.

DC74143 R805

R805 is a small molecule modulator of gp130 receptor pro-inflammatory signaling, targets a signaling tyrosine 814 (Y814) within gp130, modulates gp130 Y814 upstream of the SRC and MAPK circuit, elicits a protective effect on tissues after injury.

457940-87-3
DC74144 RA 5557

RA 5557 is a brain-penetrant, selective, oral UGT8 inhibitor, inhibits galactosylceramide biosynthesis.

2414352-73-9
DC74145 RBS-10

RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1.

352341-77-6
DC74146 RECTAS

RECTAS is a small molecule splice modulator that corrects aberrant splicing of familial dysautonomia (FD), promotes exon 20 inclusion of IKBKAP pre-mRNA and expression of IKAP.

1971086-66-4
DC74147 RF03176

RF03176 is a selective AQP9 inhibitor with IC50 of 1.3 uM (inhibition of CHO-AQP9 cell water permeability).

685123-50-6
DC74148 RG100204

RG100204 is a novel selective, small molecule inhibitor of the neutral solute channel Aquaporin 9 (AQP9), inhibits AQP9 water permeability (IC50=110 nM) and AQP9 glycerol permeability (IC50=76 nM).

2140901-88-6
DC74149 Ro 48-8071

Ro 48-8071 is a potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.

161582-11-2
DC74150 RPE65-61

RPE65-61 ((±)-RPE65-61) is a selective, non-retinoid and uncompetitive inhibitor of RPE65 (a key enzyme in the visual cycle), inhibits the retinol isomerase activity of RPE65 in vitro with IC50 of 80 nM.

2883452-77-3
DC74151 RPI-194

RPI-194 is a novel troponin activator that binds to cardiac/slow skeletal muscle troponin, binds to cardiac troponin with KD of 24 uM, stabilizing the activated complex between troponin C and the switch region of troponin I.

DC74152 RTI-263

RTI-263 (SerPheLysAsn-NH2) is a potent, selective tetrapeptide neuropeptide S receptor (NPSR, GPR154) biased agonist with EC50 of 3.02 nM for hNPSR calcium mobilization.

DC74153 RU-NT-206

RU-NT-206 is a small molecule inhibitor targeting the P-stalk binding pocket of ricin toxin A subunit (RTA) with IC50 of 7 uM, inhibits catalytic activity and protects cells against ricin and Stx2 holotoxins.

1038304-09-4
DC74154 RX-105

RX-105 (RX105) is a small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs) with anti-inflammatory properties, binds directly to glycosaminoglycans (GAGs).

449767-89-9
DC74155 RX-207

RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo.

918328-92-4
DC74156 S-181 Featured

S-181 (S 181) is a specific small-molecule activator (modulator) of β-glucocerebrosidase (GCase) with AC50 of 1.49 uM and a maximum activation of 780%.

2270984-21-7
DC74157 S202

S202 is a potent, selective and brain-penetrant small molecule inhibitor of ceramide galactosyltransferase (CGT) with IC50 of 15 nM in the cell-lysate assays and 3.6 nM in intact-cell assays.

DC74158 S9-A13 Featured

S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively.S9-A13 does not inhibit other members of the SLC26 family and has no effects on Cl− channels such as CFTR, TMEM16A, or VRAC.S9-A13 (0-1 uM ) inhibits SLC26A9 currents in a dose-dependent manner in HEK293 cells, but shows little effects on CFTR currents in HEK293 cells at the highest concentration (5 uM).S9-A13 has a minor effect on ion transport in human airway epithelial cells and mouse trachea, despite clear expression of SLC26A9 in the apical membrane of ciliated cells.

1223771-84-3
DC74159 SACLAC

SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines.

2248703-42-4
DC74160 SAN4825

SAN4825 is a selective small-molecule inhibitor of cardiac ADP-ribosyl cyclase (ADPR cyclase) with IC50 of 0.13 uM.

158020-72-5
DC74161 SAR439883 Featured

SAR439883 (SAR 439883) is a novel potent, selective, orally active PKR inhibitor with IC50 of 0.68/0.69 uM against hPKR/mPKR, respectively.

DC74162 SB1501

SB1501 (SB 1501) is a bioactive compound that reduces fat accumulation by elevating mitochondrial biogenesis and fatty acid oxidation via the PGC-1α-UCP1 pathway, shows anti-obesity effects in vivo.

2757411-32-6
DC74163 SBI-0802936

SBI-0802936 (SBI 0802936) is an analog of SMIP004-7, inhibits NADH:ubiquinone oxidoreductase (complex I), 4-6 times more potently than SMIP004-7, acting in the same uncompetitive fashion as SMIP004-7.

1946799-48-9
DC74164 SBL-105

SBL-105 (SBL105) is a potent, selective DHODH inhibitor with IC50 of 48.48 nM (rh DHODH).

DC74166 SB-U015

SB-U015 is a MitoQ derivative and tumor necrosis factor receptor-associated protein 1 (TRAP1) inhibitor.

DC74167 SC-919

SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively.

2245949-62-4
DC74168 Secdin

Secdin is a small-molecule inhibitor of Arabidopsis thaliana ADP-ribosylation factor (ARF)-guanine nucleotide exchange factors (GEFs), impaires both hypocotyl and root growth in young Arabidopsis seedlings with IC50 of 4 uM.

701231-07-4
DC74169 Seletracetam

Seletracetam (ucb 44212) is a high affinity for the synaptic vesicle protein 2A (SV2A) than levetiracetam with 10-fold, exhibits anticonvulsant properties in animal models of epilepsy.

357336-74-4
DC74170 SFI003

SFI003 is novel serine/arginine-rich splicing factor 3 (SRSF3) inhibitor, inhibits the proliferation and migration of CRC cells, inhibits the proliferation of HCT-116 with IC50 of 8.78 uM.

2361332-90-1
DC74171 SHR170008

SHR170008 is a highly potent, small molecule CD73 inhibitor with IC50 of 0.05 nM against human CD73 soluble enzyme.

DC74172 SI-2 hydrochloride

A potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2.

DC74173 Siastatin B

Siastatin B is a potent and effective iminosugar inhibitor of diverse glycosidase classes, namely, sialidases, β-d-glucuronidases, and N-acetyl-glucosaminidases.

54795-58-3
DC74174 SJ572946

SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays.

78584-09-5
DC74175 SMC-21598

SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3.

3392-07-2
DC74176 SMIP004-7

SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I).

72072-16-3
DC74177 SN34960 Featured

SN34960 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 6.65 uM, shows suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo.

1567836-70-7
DC74178 SP-8008

SP-8008 is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation.

2088247-61-2
DC74179 SPI-0324

SPI-0324 (SPI-24) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.52 uM, without affecting WT Htt.

753466-41-0
DC74180 SPI-1477

SPI-1477 (SPI-77) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.1 nM, without affecting WT Htt.

1030179-06-6
DC74181 SPI-21

SPI-21 (Spt5-Pol II inhibitor 21) is a small-molecule inhibitor of Spt5-Pol II with IC50 of 25.2 uM.

204703-71-9
DC74182 SpiD7

SpiD7 is a spirocyclic dimer compound that activates the unfolded protein response (UPR), selectively inhibits growth and induce apoptosis of cancer cells.

2230733-82-9
DC74183 SR-9011 hydrochloride

A potent, small molecule nuclear receptors REV-ERBα/β agonist with IC50 of 670/800 nM, respectively.

DC74184 SRP-001

SRP-001 is a non-opioid and non-hepatotoxic small molecule ApAP analog, induces analgesia via N-arachidonoylphenolamine (AM404) formation, and generates higher amounts of AM404 than ApAP.

2290606-49-2
DC74185 SS-1-148 Featured

SS-1-148 is a potent, selective inhibitor of human ornithine δ-aminotransferase (hOAT) with Ki of 60 uM, shows excellent selectivity over other related aminotransferases (e.g., GABA-AT).

2829349-57-5
DC74186 SST0871AA1

SST0871AA1 is a small molecule Heparanase (Hpse) inhibitor with IC50 of 0.64 uM.

2245102-65-0
DC74187 SST0872AA1

SST0872AA1 is a potent, small molecule Heparanase (Hpse) inhibitor with IC50 of 0.08 uM.

2245200-10-4
DC74188 STF-1084

STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM.

2298390-71-1
DC74189 STOCK1S-14279

STOCK1S-14279 (Stock 1S-14279) is a specific small-molecule SPAK kinase (STK39) inhibitor with IC50 of 0.26 uM, inhibits SPAK-regulated phosphorylation and activation of NCC and NKCC1.

134897-45-3
DC74190 Succinyl phosphonate

Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue, α-ketoglutarate dehydrogenase inhibitor, effectively inhibits α-ketoglutarate oxidative decarboxylation.

26647-82-5
DC74191 SW088799

SW088799 is a small molecule glucagon release inhibitor with IC50 of 1.26 uM, with minimal impact on insulin release.

451476-67-8
DC74192 SYNTi

SYNTi is a small molecule PDZ domain inhibitor targeting the syndecan/syntenin protein-protein interaction with IC50 of 400 nM.

DC74193 Synucleozid hydrochloride

Synucleozid hydrochloride (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site.

2741856-68-6
DC74195 TH301

TH301 (TH 301) is a selective small molecule stabilizer of Cryptochrome 2 (CRY2). KL101 showed selectivity over CRY1, and no or only minor effects on CKIδ, CKIα and CK2 activities in vitro.

450338-32-6
DC74196 TH8535

TH8535 (TH-8535) is a potent, selective inhibitor of 8-oxo Guanine DNA Glycosylase 1 (OGG1) with IC50 of 0.2 uM.

2375215-53-3
DC74197 TMX-4084

TMX-4084 (TMX4084) is a highly potent, selective PIP4K2C binder with KD of 7.3 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).

2867519-45-5
DC74198 TMX-4102 Featured

TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).

DC74199 TOP5300

TOP5300 (TOP05300) is a potent, selective, orally active allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 9.72 nM, 80-fold selectivity over hLHR.

1848981-48-5
DC74200 TOP5668

TOP5668 (TOP05668) is a potent, selective, orally active allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 2.2 nM, 80-fold selectivity over hLHR.

1850256-71-1
DC74201 Tpm1.8/9-1

Tpm1.8/9-1 (CID 6494468) is a specific small molecule inhibitor of Tpm1.8/9, antagonizes Tpm1.8/9's effects on EMT, Wnt signaling, and resistance to chemotherapy.

883542-35-6
DC74202 Tpm1.8/9-3

Tpm1.8/9-3 (CID 18973468) is a specific small molecule inhibitor of Tpm1.8/9, antagonizes Tpm1.8/9's effects on EMT, Wnt signaling, and resistance to chemotherapy.

187264-03-5
DC74203 TR-107 Featured

TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement.

2485052-87-5
DC74204 trans-MiM111

trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93).

2460815-44-3
DC74205 Tryptolinamide Featured

Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive

260798-40-1
DC74206 TTFB

TTFB (ZAC antagonist TTFB) is a selective antagonist (negative allosteric modulator) of Zinc-Activated Channel (ZAC) with IC50 of 3 uM.

352560-76-0
DC74207 TXX-1-10

TXX-1-10 (CB1-8) is a small chemical molecule that inhibits HPIP oncoprotein expression, suppresses breast cancer cell growth and metastasis in vitro and in vivo.

2489250-48-6
DC74208 UAB126

UAB126 (UAB 126) is a novel rexinoid-like small molecule that show positive effects on metabolic syndrome without the known side effects of potent rexinoids.

1854907-40-6
DC74209 UbV SP.1

UbV SP.1 is potent, selective inhibitor of STAMBP isopeptidase activity with KD of 0.05/0.18 uM for STAMBP/STAMBPL1, respectively.

DC74210 UbV SP.3

UbV SP.3 is potent, selective inhibitor of STAMBP isopeptidase activity with KD/IC50 of 60/9.8 nM, with significant preferential binding to STAMBP over STAMBPL1 (250 -fold selectivity).

DC74212 UNC10245131

UNC10245131 (UNC 10245131) is a potent, selective cyclic peptide inhibitor of calcium and integrin binding protein 1 (CIB1) with ITC Kd of 6.17 nM.

DC74213 UNC10245350

UNC10245351 is a N-terminal HIV Tat conjugate to UNC10245092, a CIB1 peptide inhibitor (Kd=192 nM), cell-penetrating.

DC74214 UNC2383

UNC2383 (UNC-2383) is a small molecule that enhances the intracellular delivery and pharmacological effectiveness of antisense oligonucleotides (ONs) and splice switching oligonucleotides (SSOs).

2123481-48-9
DC74215 UNC4850

UNC4850 (UNC-4850) is a specific small-molecule inhibitor toward CDY Chromodomain CDYL1/2 with Kd of 0.47/0.42 uM, >10-fold selectivity over CDY1, CBX5 and CBX7.

DC74216 UNC5452

UNC5452 is a selective NIMA-related kinase 1 (Nek1) inhibitor with IC50 of 4.3 uM.

943434-15-9
DC74217 UNC-CA157

UNC-CA157 is a selective small molecule inhibitor of the archetypal UbiB member COQ8A with IC50 of 580 nM, shows clear preference for COQ8A over COQ8B.

2190517-67-8
DC74218 UT-59 Featured

UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.

1111234-96-8
DC74219 UTBinh-14

UTBinh-14 is a potent, highly selective inhibitor for urea transporter UT-B with IC50 of 11 nM, with over a thousand-fold selectivity over UT-A.

892742-76-6
DC74220 VJDT

VJDT (TREM1 inhibitor) is a novel small molecule inhibitor of triggering receptor expressed on myeloid cell 1 (TREM1), effectively blocks TREM1 signaling.

2765319-65-9
DC74221 WX-02-37

WX-02-37 is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.5 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory ar

DC74222 XEN 602

XEN 602 (XEN602) is a potent, specific divalent metal transporter 1 (DMT1) inhibitor that inhibits Mn incorporation in HEK293 cells with IC50 of 0.3 nM.

DC74223 X-Neu5Ac Featured

X-Neu5Ac (sodium) is a substrate for chromogenic assay of neuraminidase activity in bacterial expression systems; with a Km of 0.89 mM for neuraminidase.

160369-85-7
DC74224 XST-20

XST-20 is a small molecule selectively targeting FOXM1 DNA-binding domain (DBD) with SPR Kd of 20 uM, effectively suppresses FOXM1 transcriptional activities and inhibits ovarian cancer cell proliferation.

723248-86-0
DC74225 YB-537 Featured

YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).

2844306-40-5
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