| DC8352 |
JZL-195
Featured
|
JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively). |
|
| DC5143 |
JZL184
Featured
|
JZL184 is a strong and selective inhibitor of Monoglyceride Lipase |
|
| DC9272 |
K 858
Featured
|
K 858 is an ATP-uncompetitive mitotic kinesin Eg5 inhibitor, which does not effect microtubule dynamics. |
|
| DC21192 |
K00546 |
K00546 is a potent inhibitor of the CDC2-like kinase CLK1 and CLK3 with IC50 of 8.9 and 29.2 nM, respectively.. |
|
| DC7742 |
K02288
Featured
|
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA. |
|
| DC9286 |
K03861
Featured
|
K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. |
|
| DC7774 |
Ripasudil(K-115)
Featured
|
K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension. |
|
| DC9625 |
K145 (hydrochloride)
Featured
|
K145 is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM.
IC50 value: 4.3 uM. |
|
| DC21196 |
K-604
Featured
|
K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2. |
|
| DC20430 |
K67 |
K67 is a specific inhibitor of the interaction between S349-phosphorylated p62 and Keap1, exhibts no inhibitory effect on the interaction of full-length Keap1 with Nrf2-ETGE or full-length Nrf2. |
|
| DC23443 |
K-777 |
K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively. |
|
| DC22131 |
K-8986 maleate |
K-8986 maleate (K8986) is a histamine H1-receptor antagonist with potential therapeutic for treatment of allergic conjunctivitis.. |
|
| DC23031 |
Astragalin
Featured
|
Kaempferol-3-glucoside is an orally bioavailable flavonoid that has been isolated from the leaves of D. kaki and R. agrestis and has anti-inflammatory activity. |
|
| DC10495 |
KAI407
Featured
|
KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. |
|
| DC23615 |
Kaitocephalin |
Kaitocephalin (PF 1191) is a non-selective ionotropic glutamate receptor (iGluR) antagonist, the first discovered natural toxin with protective properties against excitotoxic-death of cultured neurons induced by NMDA or AMPA/kainate receptors. |
|
| DC12420 |
KAN0438241 |
KAN0438241 (KAN-0438241) is a potent, selective PFKFB3 inhibitor with IC50 of 0.19 uM, 20-fold selectivity over PFKFB4 and no significant inhibition on PFKFB1 and 2.. |
|
| DC12419 |
KAN0438757 |
KAN0438757 (KAN-0438757) is a potent, selective PFKFB3 inhibitor, the ester prodrug of KAN0438241 with enhanced cell permeability. |
|
| DC10216 |
Kanamycin sulfate |
Kanamycin sulfate(Kanamycin monosulfate) is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. |
|
| DC21198 |
KAR-5417 |
KAR-5417 is a potent, selective TPH1 (tryptophan hydroxylase-1) inhibitor with IC50 of 33 nM. |
|
| DC21199 |
KAR-5585
Featured
|
KAR-5585 (Rodatristat) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice. |
|
| DC21749 |
Karonudib |
Karonudib (TH1579) is an analogue of TH588, a potent, selective MTH1 inhibitor with good oral availability and demonstrates excellent pharmacokinetic and anti-cancer properties in vivo.. |
|
| DC7669 |
Kartogenin (KGN)
Featured
|
Kartogenin(KGN) is a small molecule stimulator of chondrogenesis; promotes chondrocyte differentiation(EC50=100 nM) and binds to filamin A. |
|
| DC8084 |
kb NB 142-70
Featured
|
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. |
|
| DC20931 |
KB SRC 4 |
KB SRC 4 (c-Src-IN-4) is a potent, highly selective c-Src kinase inhibitor with Ki of 44 nM, does not inhibit c-Abl up to 125 uM, and binds to c-Src-TM (Q275G, C277Q, F278Y) with similar potency to that of wild-type c-Src. |
|
| DC11237 |
KB-141 |
KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα. |
|
| DC11240 |
KBFM123 |
KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM). |
|
| DC7717 |
kb-NB77-78
Featured
|
kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor). |
|
| DC12638 |
KBP-5074 |
KBP-5074 (KBP5074) is a novel non-steroidal, highly selective mineralocorticoid receptor antagonist for the treatment of hypertensive chronic kidney disease.. |
|
| DC7832 |
KB-R7943 mesylate
Featured
|
KB-R7943 mesylate is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 mM). |
|
| DC10852 |
KBU2046
Featured
|
KBU2046, is a small molecule that attaches to tumor proteins involved in metastasis and disables them, so they can’t travel to distant organs. |
|
