| DC20621 |
KC01 |
KC01 is a potent and selective inhibitor of ABHD16A with IC50 of 90 nM for hABHD16A, 520 nM for mABHD16A. |
|
| DC8447 |
KC7F2
Featured
|
KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study. |
|
| DC12416 |
KCI807 |
KCI807 (KCI-807) is a lead molecule that selectively disrupts ELK1-dependent promoter activation by wild-type and variant Ars (IC50=0.53 uM) without interfering with ELK1 activation by ERK. |
|
| DC7871 |
KCL-440 |
KCL-440 is a a new poly(ADP-ribose) polymerase- PARP inhibitor. |
|
| DC12615 |
KCN1 |
KCN1 (HIF inhibitor KCN1) is a small molecule inhibitor of the HIF-1 pathway, antagonizes HIF transcription in bioassay, blocks the p300/HIF-1α interaction, and exert potent anticancer activity in vitro and in vivo. |
|
| DC10586 |
KDM4D-IN-1
Featured
|
KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM. |
|
| DC12519 |
KDM5A covalent inhibitor N71 |
KDM5A covalent inhibitor N71 is an irreversible KDM5A inhibitor (IC50=0.22 uM) that covalently interacts with Cys481, >20-fold selectivity over KDM4A.. |
|
| DC12520 |
KDM5A covalent inhibitor N73 |
KDM5A covalent inhibitor N73 is the the isopropyl ester derivative of N71, an irreversible KDM5A inhibitor (IC50=0.22 uM) that covalently interacts with Cys481, >20-fold selectivity over KDM4A.. |
|
| DC23375 |
KDM5-C49 |
KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively. |
|
| DC23376 |
KDM5-C70
Featured
|
KDM5-C70 is the cell-permeable derivative of KDM5-C49, potent, selective and cell permeable KDM5 inhibitor with IC50 of 0.3, 0.3 and 0.58 uM for KDM5A, B and C, respectively. |
|
| DC10285 |
KDM5-IN-1
Featured
|
KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM. |
|
| DC23369 |
KDM-IN-6 |
KDM-IN-6 is a potent, highly selective and cell-active inhibitor of KDM2A/7A with IC50 of 0.16 and 0.19 uM,respectively. |
|
| DC20226 |
KDOAM25（GTPL8576）
Featured
|
KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. |
|
| DC23673 |
KDS2010 |
KDS2010 (KDS-2010, KDS 2010) is a potent, highly selective, reversible Monoamine oxidase-B (MAO-B) inhibitor with IC50 of 7.6 nM. |
|
| DC10746 |
KDU691
Featured
|
KDU691 is a PI4K inhibitor. |
|
| DC23778 |
KDU731 |
KDU731 is a potent, selective parasite Cryptosporidium lipid kinase PI4K (phosphatidylinositol-4-OH kinase) inhibitor with IC50 of 25 nM, displays >50-fold selectivity window against the human PI4K IIIβ homologue. |
|
| DC11627 |
KEA1-97
Featured
|
KEA1-97 (KEA 1-97) is a small molecule that disrupts the interaction of thioredoxin with caspase 3. |
|
| DC12272 |
Kelatorphan |
Kelatorphan is a full inhibitor of enkephalin degrading enzymes. |
|
| DC5093 |
NSC-664704(Kenpaullone)
Featured
|
Kenpaullone is an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β). |
|
| DC9004 |
Ketoprofen |
Ketoprofen (Actron) is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively. |
|
| DC9100 |
Ketorolac Tromethamine |
Ketorolac (Ketorolac tromethamine, Toradol) is a non-selective COX inhibitor with strong analgesic activity. |
|
| DC9132 |
Ketotifen fumarate |
Ketotifen (fumarate) is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks. |
|
| DC8326 |
Kevetrin HCl
Featured
|
Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. |
|
| DC10654 |
KG-501(Naphthol AS-E phosphate)
Featured
|
KG-501 is a small molecule inhibitor of Aldolase, Histochemical substrate for alkaline phosphatases. |
|
| DC21200 |
KG-548 |
KG-548 is an ARNT/TACC3 disruptor (IC50=25 uM) that selectively bind within the ARNT PAS (Per-ARNT-Sim) domain that recruits TACC3.. |
|
| DC22752 |
KGA-2727
Featured
|
KGA-2727 is a potent, selective SGLT1 inhibitor with Ki of 97.4 nM, >100-fold selectivity over SGLT2. |
|
| DC23680 |
KGP-420 |
KGP-420 is the water-soluble phosphate prodrug of KGP-94 in vivo studies, KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM. |
|
| DC23674 |
KGP-94 |
KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM, shows no significant inhibitory effect on cathepsin B (IC50>10 uM). |
|
| DC22230 |
KH-176 |
KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system. |
|
| DC21201 |
KH 176 |
KH176 is a chemical entity derivative of Trolox and small molecule ROS-redox modulator, shows potential treatment for mitochondrial disorders. |
|
